磁共振成像中磁体的匀场线圈设计与磁场计算

根据静磁场的基本特征及有源匀场的方法，分析了具有柱面形状的两类匀场线圈的结构设计与优化方法，并导出线圈磁场的高精度数值算法．以此设计的匀场线圈成功应用于超低场ＭＲＩ的０．０４Ｔ常导磁体的匀场中．     

AN INVESTIGATION OF THE RELATION BETWEEN COTTON FIBRE PROPERTIES AND YARN QUALITY BY USING HIGH VOLUME INSTRUMENT(HVI)SYSTEM

The objective of this paper is to establish reliable prediction equations relating cotton fibreproperties measured by HVI system and yarn quality,A useful statistical method is adopted for de-veloping a multiple regression model interpreting the relation between the data of Spinlab HVIfibre properties and quality parameters of yarn STQ (Strength Tex Quotient).The percent relativecontribution of a fibre property with respect of STQ is also assessed.The results show that the totalcontribution of the HVI measured fibre properties can account for 77.4% of known variation ofyarn STQ.The main feature of the approach is its flexibility in accommodating all fibre properties.The examination of regression equation showed that it could be well applied to predict STQ ofyarns spun from the same spinning system,but,for different spinning systems and also for yarns ofdifferent linear density,modification of the equation would be needed.     

型转化法平面连杆机构结构分解路线的自动生成

用求最短回路的方法,通过寻找一组机构的有序独立的基本回路,并满足此组回路中为正值的回路自由度之和最小,只需输入少量直观的杆副信息,计算机可自动确定含P副、复铰的任何平面连杆机构的优化分解路线。     

Systematic screen for human disease genes in yeast

High similarity between yeast and human mitochondria allows functional genomic study of Saccharomyces cerevisiae to be used to identify human genes involved in disease. So far, 102 heritable disorders have been attributed to defects in a quarter of the known nuclear-encoded mitochondrial proteins in humans. Many mitochondrial diseases remain unexplained, however, in part because only 40-60% of the presumed 700-1,000 proteins involved in mitochondrial function and biogenesis have been identified. Here we apply a systematic functional screen using the pre-existing whole-genome pool of yeast deletion mutants to identify mitochondrial proteins. Three million measurements of strain fitness identified 466 genes whose deletions impaired mitochondrial respiration, of which 265 were new. Our approach gave higher selection than other systematic approaches, including fivefold greater selection than gene expression analysis. To apply these advantages to human disorders involving mitochondria, human orthologs were identified and linked to heritable diseases using genomic map positions.     

Adaptive terminal sliding mode control for high-order nonlinear dynamic systems

An adaptive terminal sliding mode control (SMC) technique is proposed to deal with the tracking problem for a class of high-order nonlinear dynamic systems. It is shown that a function augmented sliding hyperplane can be used to develop a new terminal sliding mode for high-order nonlinear systems. A terminal SMC controller based on Lyapunov theory is designed to force the state variables of the closed-loop system to reach and remain on the terminal sliding mode, so that the output tracking error then converges to zero in finite time which can be set arbitrarily. An adaptive mechanism is introduced to estimate the unknown parameters of the upper bounds of system uncertainties. The estimates are then used as controller parameters so that the effects of uncertain dynamics can be eliminated. It is also shown that the stability of the closed-loop system can be guaranteed with the proposed control strategy. The simulation of a numerical example is provided to show the effectiveness of the new method.     

Geochronology of source materials from high-pressure and ultrahigh-pressure metamorphic rocks in Jurassic sedimentary rocks of Hefei Basin

Eclogite cobbles were discovered by Wang et al. (2001) in the Fenghuangtai Formation of the northern margin of Dabie Mountains in the Dushan area of Anhui Province, China[1]. They proposed that after the formation during the Triassic, the high-pressure (HP) and ultra-high-pressure (UHP) metamorphic rocks reached the sur-face through exhumation and uplifting before the late Ju-rassic. However, they have not provided any evidence about isotopic ages. One kind of cobbles of HP-UHP rocks w…     

Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin

Small molecules such as NO, O2, CO or H2 are important biological ligands that bind to metalloproteins to function crucially in processes such as signal transduction, respiration and catalysis. A key issue for understanding the regulation of reaction mechanisms in these systems is whether ligands gain access to the binding sites through specific channels and docking sites, or by random diffusion through the protein matrix. A model system for studying this issue is myoglobin, a simple haem protein. Myoglobin has been studied extensively by spectroscopy, crystallography, computation and theory. It serves as an aid to oxygen diffusion but also binds carbon monoxide, a byproduct of endogenous haem catabolism. Molecular dynamics simulations, random mutagenesis and flash photolysis studies indicate that ligand migration occurs through a limited number of pathways involving docking sites. Here we report the 1.4 A resolution crystal structure of a ligand-binding intermediate in carbonmonoxy myoglobin that may have far-reaching implications for understanding the dynamics of ligand binding and catalysis.     

一种基于扩展FP-TREE的服务推荐方法

针对协作过滤推荐的矩阵稀疏性与扩展膨胀问题,提出一种基于扩展FP-TREE的改进方法.将用户的情境取值抽象为情境空间状态,通过挖掘情境状态与服务的关联进行服务推荐.引入倒排索引扩展FPTREE频繁项头表,建立状态-状态与服务-服务关联;通过索引树表示状态-服务关联,给出扩展FP-TREE与协作过滤矩阵的映射机制,在继承协作过滤的基础上极大地压缩了过滤矩阵.仿真实验表明:与传统的协作过滤推荐算法相比,该推荐方法具有更高的效率.     

儿童过敏性紫癜研究进展

从流行病学、病因和发病机制、临床表现、辅助检查、诊断标准、治疗方法、预后及随访等方面对儿童过敏性紫癜（HSP)的研究进行了综述.已有的研究充分表明，HSP病因及发病机制尚不明确，免疫及遗传的作用机制还需进一步研究.HSP在临床上缺乏特异性的检查手段，主要依靠患儿症状及体征来诊断；当患儿出现罕见或不常见的临床表现时，组织病理学分析就显得尤为重要.目前国内外尚无统一性及特异性的治疗方案，病情轻者多以对症治疗为主，病情严重者多采用激素进行个体化治疗，但相关的治疗方案还需大样本、多中心临床试验研究以及循证医学验证.HSP短期预后较好，长期预后主要与肾脏受累相关，而减少肾脏受累的关键在于早发现，早诊断，早治疗.