孕激素相关子宫内膜蛋白在胃癌早期诊断、预后中的作用

为使用生物信息学系统分析孕激素相关子宫内膜蛋白(Progestagen-associated endometrial protein, PAEP)在胃癌中的早期诊断和预后预测性能及免疫浸润相关性,该研究构建预测模型ROC曲线和偏差校正曲线检验其性能准确性,并通过细胞实验进一步验证分析结果.生信分析结果显示,与正常组织相比,胃癌组织中PAEP的表达较高,在早期（T1期、N0期、M0期）即有统计学意义（P＜0.001）,且诊断胃癌的准确性较高（ROC曲线下面积为0.889）;PAEP高表达的胃癌患者预后较差（P≤0.001）;TNM分期越晚,年龄越大,PAEP表达越高,胃癌患者生存概率越低,偏差校正曲线接近理想曲线（45°线）,显示预测结果良好;PAEP的表达与胃癌中的中性粒细胞、巨噬细胞的浸润水平呈正相关趋势,与B细胞、中央记忆型T细胞、T细胞呈显著的负相关趋势.qRT-PCR和Western blot结果显示,HGC-27、BGC-823、MKN-45、SGC-7901和AGS细胞中PAEP基因转录水平和蛋白表达水平均显著高于GES-1. 结果表明了PAEP 蛋白可用于胃癌诊断和预后的生物标志物,并进行了实验验证,其机制与免疫有关.     

油库发油控制及管理系统的研究

阐述了油库发油体积及重量的测量过程,讨论了控制及管理的功能要求,提出了设定关阀提前量ΔＸ,并控制调整其大小以提高发油精度的思想。系统采用主从式上下两级微机网络。文中给出了该系统的实现方法,同时论述了保证系统安全运行的措施。     

连续滚动生产作业安排中初始状态非平凡的P//C_(max)问题

以实际中连续滚动生产为背景,研究了一类新的平行机作业安排问题,即初始状态非平凡的Ｐ∥Ｃ_ｍａｘ问题。基于经典的Ｂｉｎ－ｐａｃｋｉｎｇ（装箱）理论和技巧,提出改进的Ｍｕｌｔｉｆｉｔ算法及相应的ＩＦＦＤ装法,并分析算法在最坏情况下的性能指标上界为４／３．最后,提出连续生产中周期滚动式作业安排的实施算法,实现了设备不空闲而连续运行。     

居住整体环境的创造—珍珠园居住小区规划设计的思考

作者在获建设部金牌奖的珍珠园试点居住小区规划设计中,将地域的自然要素一人造环境巧妙地结合,创造了有特色的空间结构和形象,创造了场所精神。规划努力创造较好的居住生态环境,布局了渗入居住空间的绿化系统和具有不同领域性的公共活动空间;采取措施减少噪音和有害气体污染;改善了日照条件,使之成为舒适宜人的居住环境。该规划精心构筑了主要的景观轴线和空间序列,创造了具有个性的、优美宜人的环境。     

Origin of immature sulfur-rich oil in Jianghan oil field

Chemical structure of immature sulfur-rich kerogen and composition of immature sulfur-rich crude oil in Jianghun oil field have been studied. In molecular level, crude oil differs from thermolysed and chemolysed products of kerogen but does resemble the bitumen in immature sulfur-rich source rock. Therefore, immature sulfur-rich oil may be derived from the expelling of bitumen rather than from thermal cracking of kerogen.     

Discovery of eclogite at northern margin of Qaidam Basin, NW China

Eclogite was first discovered at the northern margin of the Qaidam Basin in this study. It occurs as pods in the gneiss sequence of Middle to Upper Proterozoic age and is mainly composed of garnet, omphacite, phengite and rutile. The garnets contain 44%-62% of almandine, 15%-33% of grossular and 12%-30% of pyrope molecules, and the omphacites contain 40%-46% of jadeite. Applying garnet_clinopyroxene thermometry and jadeite geobarometry, the peak conditions of eclogite facies metamorphism occurred at about (722±123)℃ and at the pressure of up to c. 22 ×10 8 Pa.     

Spontaneous transformation of C60Br24 to C60 in solvents

It was found that C₆₀Br₂₄ transforms to C₆₀ spontaneously in some solvents. The intermediate, C₆₀Br₈, can be separated in some cases. When the bromine trap, phenol, was added,p-bromophenol and other brominated product were obtained and identified. The influences of time, the kind of solvent, etc were investigated. Possible mechanism was suggested. Supported by the National Natural Science Foundation of China Liu Ying: born in 1969, Ph. D     

盐酸米诺环素胶囊溶出度测定方法的改进

关于盐酸米诺环素胶囊溶出度测定方法和标准修订．采用紫外法,以水为溶剂,检测波长为（３４６±２）ｎｍ,在５～３０μｇ／ｍＬ浓度范围内有良好线性关系（ｒ＝０．９９９９）．平均回收率为（１００．６±０．５８）％,测定浓度为１５μｇ／ｍＬ．在此条件下可得准确的结果．     

线性系统参数估计的改进凸多面锥法

文章对现有的凸多面锥法进行了改进．改进方法采用旧凸多面锥的边的凸组合来求新多面锥的新边,从而提高了算法的稳定性．并且将凸多面锥算法扩展到输出误差模型的参数估计上．仿真算例验证了改进方法的有效性．     

CuO／SiO2和CuO—ZnO／SiO2催化剂的热分析性质

用差热分析（ＴＧ／ＤＴＡ）技术研究了ＣｕＯ／ＳｉＯ２和ＣｕＯ－ＺｎＯ／ＳｉＯ２催化剂于Ｈ２气下的还原行为和在Ｏ２气下的氧化行为及对其催化性能的影响。结果表明,ＺｎＯ的加入有利于催化剂的热稳定性,并对ＣｕＯ的还原有促进作用;在有氧化气氛存在时,ＺｎＯ的加入不利于保持Ｃｕ＾０的还原态。