全文获取类型
收费全文 | 5136篇 |
免费 | 159篇 |
国内免费 | 215篇 |
专业分类
系统科学 | 213篇 |
丛书文集 | 125篇 |
教育与普及 | 110篇 |
理论与方法论 | 20篇 |
现状及发展 | 36篇 |
研究方法 | 37篇 |
综合类 | 4968篇 |
自然研究 | 1篇 |
出版年
2024年 | 23篇 |
2023年 | 37篇 |
2022年 | 79篇 |
2021年 | 66篇 |
2020年 | 51篇 |
2019年 | 24篇 |
2018年 | 34篇 |
2017年 | 42篇 |
2016年 | 50篇 |
2015年 | 84篇 |
2014年 | 141篇 |
2013年 | 139篇 |
2012年 | 161篇 |
2011年 | 189篇 |
2010年 | 154篇 |
2009年 | 177篇 |
2008年 | 231篇 |
2007年 | 222篇 |
2006年 | 185篇 |
2005年 | 193篇 |
2004年 | 158篇 |
2003年 | 130篇 |
2002年 | 147篇 |
2001年 | 159篇 |
2000年 | 161篇 |
1999年 | 287篇 |
1998年 | 246篇 |
1997年 | 275篇 |
1996年 | 264篇 |
1995年 | 233篇 |
1994年 | 224篇 |
1993年 | 167篇 |
1992年 | 142篇 |
1991年 | 133篇 |
1990年 | 154篇 |
1989年 | 119篇 |
1988年 | 100篇 |
1987年 | 66篇 |
1986年 | 40篇 |
1985年 | 10篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1970年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有5510条查询结果,搜索用时 312 毫秒
171.
172.
The rotor with bending faults that occurrs on the rotating machinery usually vibrates seriously. This paper investigates to apply the active balancing device on a flexible rotor with bending faults to solve the vibration problem. Two problems are studied by finite element method firstly: Where the balance actuator is fixed on the shaft and how much the balancing capacity of the active balancing device is needed. The experiment is then carried out on the test rig, which consists of a flexible rotor with bending faults. The test results indicate that the bending rotor peak vibration response can be decreased from 550~m to 40~tm below by using the active balancing device. The peak vibration response decreases approximately by 93 %. The synchronous vibration due to the rotor bending faults can be controlled effectively by using ac- tive balancing device. The active balancing device is especially adapted to solve the problem caused by thermal distortion with time-variation and randomness, which is varied with working conditions, thus it has good practical value in practice. 相似文献
173.
174.
德士古渣油气化系统数学模拟 总被引:2,自引:0,他引:2
对德士古渣油气化系统进行了过程分析,建立了单元设备物料和热量衡算的数学模型,提出了计算气化炉微量组分的方法。运用序贯模块法对该系统进行了稳态模拟计算,结果同设计值和工厂值吻合较好。 相似文献
175.
Lin Z Bei JX Shen M Li Q Liao Z Zhang Y Lv Q Wei Q Low HQ Guo YM Cao S Yang M Hu Z Xu M Wang X Wei Y Li L Li C Li T Huang J Pan Y Jin O Wu Y Wu J Guo Z He P Hu S Wu H Song H Zhan F Liu S Gao G Liu Z Li Y Xiao C Li J Ye Z He W Liu D Shen L Huang A Wu H Tao Y Pan X Yu B Tai ES Zeng YX Ren EC Shen Y Liu J Gu J 《Nature genetics》2012,44(1):73-77
To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis. 相似文献
176.
Hu Z Xia Y Guo X Dai J Li H Hu H Jiang Y Lu F Wu Y Yang X Li H Yao B Lu C Xiong C Li Z Gui Y Liu J Zhou Z Shen H Wang X Sha J 《Nature genetics》2012,44(2):183-186
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men. 相似文献
177.
178.
The frequency domain ∑A-DPCA processing (F-∑A-DPCA) is investigated in details and an improved scheme for the F-∑A-DPCA is proposed, which can significantly reduce the computational burden. In practice, because of the sum and difference beam pattern designed independently and other system errors, the clutter suppression of the time domain ∑A-DPCA processing (T-∑A-DPCA) is significantly degraded. However, the F-∑A-DPCA adaptively calculates the optimum gain ratio for motion compensation within each Doppler cells which is robust to system errors. Theoretical analysis and simulation results are presented to validate that the F-∑A-DPCA can achieve superior performance of clutter cancellation than the time domain processing, and its performance can be significantly increased if more pulses are used for the Doppler filtering. The improved approach is efficient, and feasible for real-time application. 相似文献
179.
Kondo Y Shen L Cheng AS Ahmed S Boumber Y Charo C Yamochi T Urano T Furukawa K Kwabi-Addo B Gold DL Sekido Y Huang TH Issa JP 《Nature genetics》2008,40(6):741-750
Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation. 相似文献
180.
红外焦平面阵列非均匀校正算法研究 总被引:6,自引:0,他引:6
红外图像的非均匀性已经成为制约红外焦平面阵列成像质量的限制性因素。本文对红外非均匀性的定义和来源进行了深入的探讨,给出了几种非均匀校正算法及其实验结果,最后对各种校正算法的特点进行了归纳总结。 相似文献