Address at the Global Summit on Merit Review

Mr.Chairman,colleagues,ladies and gentlemen, Good morning, It is a great honor for me to be invited to attend this Global Summit on Merit Review.As the topic for this summit,merit review or peer review constitutes the core mechanism for science funding and functions as the life line of the quality of research projects funded. We are delighted to see that,after a series of regional meetings,6 principles for scientific merit review are proposed and will be established by a common declaration at this summit upon the consensus reached     

宜万铁路岩溶隧道施工地质技术

以宜万铁路岩溶隧道的施工地质技术实践为例,介绍了施工地质作为工程勘察阶段工程地质勘探在施工阶段的延续,用以在施工过程中解决勘察阶段所没有或不能解决的工程地质问题。施工地质以超前地质预测预报为主体,以规避大型施工地质灾害为目的,在施工阶段针对可能发生的隧道围岩变更;可能存在的溶腔、断层构造、地下暗河的预测预报;可能引发的水文环境地质问题;工程竣工以后可能存在的隐伏地质病害等,在隧道施工环境条件下为保证施工进度、保证施工安全、保证工程效益、保证工程质量所进行的综合工程地质工作。施工地质包括综合超前地质预报、水文观测和隧道周边及隧底隐伏岩溶探查。     

低信噪比图像中运动点目标的检测方法

图像中点目标的检测是目前比较活跃的研究领域,它在制导、天文观测、遥感等学科中有着重要的应用价值。在低信噪比条件下,要从图像中检测出运动的点目标存在着不少困难。本文首先分析了低信噪比情况下检测的难点,然后对目前七种有代表性的方法加以评介。     

处理黑色体系的几种化学计量学算法的比较

对近期提出的几种处理黑色分析体系的二维数据的算法－－渐进因子分析法，迭代目标转换因子分析法，演进因子分析法，直观推导式渐进因子分析法等４种算法进行比较研究，为了方便比较，以光谱或色谱的协方差阵的行列式作为体系重叠度的度量，在此基础上，对确定未知混合物组分数和纯组分光谱及色谱的分辨结果进行了较详细的讨论，ＨＥＬＰ给出最佳结果。     

320排CT低碘浓度联合低管电压在冠脉成像中的应用研究

目的探讨320排螺旋CT低管电压技术联合低碘浓度在冠状动脉成像中的可行性.方法将40例疑似冠心病患者随机分为两组,使用东芝320排螺旋CT进行冠状动脉扫描,分别对两组图像质量进行主观和客观评分,对比有效辐射剂量及碘摄取量.结果 A,B两组的有效辐射剂量及碘摄入量比较差异具有统计学意义(P0.05),B组患者有效辐射剂量低于A组,且有效辐射剂量较A组降低72.95%,B组患者有效碘摄入量较A组减少18.29%,两组图像噪声值、左冠脉开口处强化CT值差异具有统计学意义(P0.05),B组图像噪声高于A组,两组图像质量主观评分比较差异无统计学意义(P0.05).结论 320排螺旋CT冠状动脉成像采用双低扫描方案能降低有效辐射剂量和碘摄入量.     

Conformations and adsorption behavior of poly（allylamine hydrochloride） studied by single molecule force spectroscopy

Poly（allylamine hydrochloride） （PAH）, which is frequently used in fabricating polyelectrolyte multilayer films, was studied by single molecule force spectroscopy （SMFS）. Plenty of force-extension curves with a long plateau were obtained in water, indicating that train-like structure was predominant when PAH was adsorbed on the substrate. It was found that the peak-type force-extension curves of PAH in water were not able to be fitted by the modified freely-jointed chain model. Additionally, there was a flat region in the derivative of force-extension curves. Thus, it was inferred that PAH chain in water was in a special conformation and underwent a ＂conformational transition＂ under the stretching of an external force. This phenomenon did not appear in the SMFS experiment in 1 mol/L urea solution, which indicated that urea was able to break the special conformation.     

Biosynthesis of selenosubtilisin: A novel way to target selenium into the active site of subtilisin

Glutathione peroxidase （GPx, EC1.11.1.9）, an important anti-oxidative selenoenzyme, can catalyze the reduction of harmful hydroperoxides with concomitant glutathione, thereby protecting cells and other biological issues against oxidative damage. It captures considerable interest in redesign of its function for either the mechanism study or the pharmacological development as an antioxidant. In order to develop a general strategy for specifically targeting and operating selenium in active sites of enzymes, the catalytically essential residue selenocysteine （Sec） was first successfully bioincorporated into the catalytic center of subtilisin by using an auxotrophic expression system. The studies of the catalytic activity and the steady-state kinetics demonstrated that selenosubtilisin is an excellent GPx-like biocatalyst. In comparison with the chemically modified method, biosynthesis exhibits obvious advantages： Sec could be site-directly incorporated into active sites of enzymes to overcome the non-specificity generated by chemical modification. This study provides an important strategy for specifically targeting and operating selenium in the active site of an enzyme.     

钻孔灌注桩常见施工质量问题及防治措施

文章通过介绍水下灌注桩施工中常见事故出现的原因,总结施工中应注意的各种预防措施及事后补救办法。