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91.
Many studies have assessed genetic changes in exotic plant species in their native and introduced ranges, but none have focused on genetic variation in native plant species in response to exotic invasion. We examine characteristics of native plant communities within and outside old (> 25 year) invasions of Acroptilon repens (Russian knapweed) and Cardaria draba (hoary cress). We also document genetic variability of 4 native grass populations ( Hesperostipa comata [needle and thread], Achnatherum hymenoides [Indian ricegrass], Sporobolus airoides [alkali sacaton], and Poa secunda [Sandberg bluegrass]) from 2 areas: adjacent to and within weed invasions. Native plant species richness and diversity did not differ between invaded and noninvaded areas. Inter-simple sequence repeat (ISSR) analysis of individual native perennial grasses of each of the 4 species suggests that populations exposed to long-term coexistence with exotics may differ from adjacent noninvaded populations. We suggest that future research efforts should focus on intraspecific diversity of native plant species to identify possible candidates for restoration following weed control. 相似文献
92.
Tildesley MJ Savill NJ Shaw DJ Deardon R Brooks SP Woolhouse ME Grenfell BT Keeling MJ 《Nature》2006,440(7080):83-86
Foot-and-mouth disease (FMD) in the UK provides an ideal opportunity to explore optimal control measures for an infectious disease. The presence of fine-scale spatio-temporal data for the 2001 epidemic has allowed the development of epidemiological models that are more accurate than those generally created for other epidemics and provide the opportunity to explore a variety of alternative control measures. Vaccination was not used during the 2001 epidemic; however, the recent DEFRA (Department for Environment Food and Rural Affairs) contingency plan details how reactive vaccination would be considered in future. Here, using the data from the 2001 epidemic, we consider the optimal deployment of limited vaccination capacity in a complex heterogeneous environment. We use a model of FMD spread to investigate the optimal deployment of reactive ring vaccination of cattle constrained by logistical resources. The predicted optimal ring size is highly dependent upon logistical constraints but is more robust to epidemiological parameters. Other ways of targeting reactive vaccination can significantly reduce the epidemic size; in particular, ignoring the order in which infections are reported and vaccinating those farms closest to any previously reported case can substantially reduce the epidemic. This strategy has the advantage that it rapidly targets new foci of infection and that determining an optimal ring size is unnecessary. 相似文献
93.
Shaw P Greenstein D Lerch J Clasen L Lenroot R Gogtay N Evans A Rapoport J Giedd J 《Nature》2006,440(7084):676-679
Children who are adept at any one of the three academic 'R's (reading, writing and arithmetic) tend to be good at the others, and grow into adults who are similarly skilled at diverse intellectually demanding activities. Determining the neuroanatomical correlates of this relatively stable individual trait of general intelligence has proved difficult, particularly in the rapidly developing brains of children and adolescents. Here we demonstrate that the trajectory of change in the thickness of the cerebral cortex, rather than cortical thickness itself, is most closely related to level of intelligence. Using a longitudinal design, we find a marked developmental shift from a predominantly negative correlation between intelligence and cortical thickness in early childhood to a positive correlation in late childhood and beyond. Additionally, level of intelligence is associated with the trajectory of cortical development, primarily in frontal regions implicated in the maturation of intelligent activity. More intelligent children demonstrate a particularly plastic cortex, with an initial accelerated and prolonged phase of cortical increase, which yields to equally vigorous cortical thinning by early adolescence. This study indicates that the neuroanatomical expression of intelligence in children is dynamic. 相似文献
94.
95.
GATA3 haplo-insufficiency causes human HDR syndrome 总被引:15,自引:0,他引:15
96.
97.
Moreira MC Klur S Watanabe M Németh AH Le Ber I Moniz JC Tranchant C Aubourg P Tazir M Schöls L Pandolfo M Schulz JB Pouget J Calvas P Shizuka-Ikeda M Shoji M Tanaka M Izatt L Shaw CE M'Zahem A Dunne E Bomont P Benhassine T Bouslam N Stevanin G Brice A Guimarães J Mendonça P Barbot C Coutinho P Sequeiros J Dürr A Warter JM Koenig M 《Nature genetics》2004,36(3):225-227
Ataxia-ocular apraxia 2 (AOA2) was recently identified as a new autosomal recessive ataxia. We have now identified causative mutations in 15 families, which allows us to clinically define this entity by onset between 10 and 22 years, cerebellar atrophy, axonal sensorimotor neuropathy, oculomotor apraxia and elevated alpha-fetoprotein (AFP). Ten of the fifteen mutations cause premature termination of a large DEAxQ-box helicase, the human ortholog of yeast Sen1p, involved in RNA maturation and termination. 相似文献
98.
Shaw C 《Population trends》2004,(115):6-15
The 2002-based national population projections, carried out by the Government Actuary in consultation with the Registrars General, show the population of the United Kingdom rising from 59.2 million in 2002 to nearly 65 million by 2031. Longer-term projections suggest the population will peak around 2050 at over 65 million and then gradually start to fall. The population will become gradually older with the median age expected to rise from 38.2 years in 2002 to 43.3 years by 2031. In 2002, there were around 850 thousand (8 per cent) more children aged under 16, than people of state pensionable age. However, from 2007, the population of pensionable age is projected to exceed the number of children. 相似文献
99.
Convergence across biomes to a common rain-use efficiency 总被引:7,自引:0,他引:7
Huxman TE Smith MD Fay PA Knapp AK Shaw MR Loik ME Smith SD Tissue DT Zak JC Weltzin JF Pockman WT Sala OE Haddad BM Harte J Koch GW Schwinning S Small EE Williams DG 《Nature》2004,429(6992):651-654
Water availability limits plant growth and production in almost all terrestrial ecosystems. However, biomes differ substantially in sensitivity of aboveground net primary production (ANPP) to between-year variation in precipitation. Average rain-use efficiency (RUE; ANPP/precipitation) also varies between biomes, supposedly because of differences in vegetation structure and/or biogeochemical constraints. Here we show that RUE decreases across biomes as mean annual precipitation increases. However, during the driest years at each site, there is convergence to a common maximum RUE (RUE(max)) that is typical of arid ecosystems. RUE(max) was also identified by experimentally altering the degree of limitation by water and other resources. Thus, in years when water is most limiting, deserts, grasslands and forests all exhibit the same rate of biomass production per unit rainfall, despite differences in physiognomy and site-level RUE. Global climate models predict increased between-year variability in precipitation, more frequent extreme drought events, and changes in temperature. Forecasts of future ecosystem behaviour should take into account this convergent feature of terrestrial biomes. 相似文献
100.
Zusammenfassung 5-Amino-Glycofuranosylimidazol-Derivative wurden durch Kondensation der Isopropylidenglycofuranosylamine mit Äthyl-N-(Cyano-N-Äthoxycarbonylmethyl)formimidat oder durch Reaktion von Äthylformimidat-Hydrochlorid mit den Furanosylaminen, wozu Äthyl--amino--cyanoacetat hinzugefügt wurde, dargestellt. Bei den Ribose- und Mannosederivaten, wurden - und -Formen als Kristalle isoliert. Eine neue stereospezifische Synthese von Xylofuranosylaminoimidazol über ein Xyloseoxazolin wird beschrieben. 相似文献