脱硫催化剂的酸法制备及性能研究

对用酸法进行催化剂制备，酸法制备的最佳镁铝比，分散介质的优化，引入对脱催化剂的氧化性能和还原性能的影响。以及实验室的还原温度等诸方面进行了研究。     

Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis

When they recognize a target cell, natural killer (NK) cells mount an attack to kill the target by exerting their cytotoxicity via the exocytosis of cytotoxic granules. Although the details of this process (which includes the movement of cytotoxic granules in the immune synapse and their fusion with the plasma membrane, releasing granzymes and perforin into the synaptic cleft) are relatively better understood, the post-exocytosis regulation of the process is still largely unknown. Here we show that a clathrin-dependent endocytosis stimulated by target cell occurs in NK92 cell line, which is closely correlated with granzyme B recovery. Inhibition of the endocytosis significantly attenuates the cytotoxicity of NK92 cells. The NK cell recovery of its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation of immune cells.     

Exome sequencing of liver fluke-associated cholangiocarcinoma

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA.     

Control of a key transition from prostrate to erect growth in rice domestication

The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication.     

频率编码脉冲信号性能分析

用大时宽带宽信号是提高雷达距离、速度及其联合分辨性能的最常用方法之一。频率编码脉冲是一种大时宽带信号,具有良好的距离分辨性能和较窄的瞬时带宽。推导了频率编码脉冲信号及步进频率脉冲信号的模糊函数,分析了其距离、速度分辨性能及其相应关系,并就有效解决其距离-速度联合测量问题进行了讨论。     

A novel process for comprehensive utilization of vanadium slag

Traditional processes for treating vanadium slag generate a huge volume of solid residue and a large amount of harmful gas, which cause serious environmental problems. In this study, a new process for the comprehensive utilization of vanadium slag was proposed, wherein zeolite A and a V₂O₅/TiO₂ system were synthesized. The structural properties of the as-synthesized zeolite A and the V₂O₅/TiO₂ system were characterized using various experimental techniques, including X-ray diffraction, X-ray fluorescence, scanning electron microscopy, and infrared spectroscopy. The results reveal that zeolite A and the V₂O₅/TiO₂ system are successfully obtained with high purity. The results of gas adsorption measurements indicate that the prepared zeolite A exhibits high selectivity for CO₂ over N₂ and is a candidate material for CO₂ capture from flue-gas streams.     

就业导向下高校新闻传播学实践教学的思考

根据当前就业形势对以实践性、应用性为主要特色的新闻传播学专业人才的要求，在分析高校专业实践教学存在的问题的基础上，提出高校新闻传播学专业实践教学应加强新闻传播学专业实践教学的规划，创新实践教学的模式，完善专业实践教学基地的建设。     

三生教育对大学生就业的影响

生命教育、生存教育、生活教育通过整合学校教育、家庭教育、社会教育的力量,激发学生的主体认知和行为实践,本文通过对生命教育、生存教育、生活教育内涵及其意义的探析,提出三生教育的实施必将推进大学生就业工作的顺利开展.     

岩溶隧道衬砌水压力分布规律研究

长期以来隧道衬砌水压力问题，一直是人们争论的焦点。依托宜万铁路岩溶隧道工程，对不同防排水方式（即全封堵、堵排结合及排放方式）的隧道衬砌水压力分布规律进行研究，研究方法主要采用模型试验及现场测试方法，模型试验的比例尺为1∶16，试验台架可同时施加土压和水压。通过模型试验得出水压力分布规律：全封堵条件下衬砌背后水压力不能折减，注浆圈也不能有效减小水压力；隧道内排水后衬砌背后水压力明显减小，并随着排水量的增加，水压力基本成直线下降；相同排水量时，注浆效果越好，衬砌背后水压力减小越明显；隧道采用全排导方式时，衬砌仍承受一定的水压。由模型试验得出的水压分布规律的部分结论，在现场水压力测试中得到了验证。