Fringe is a glycosyltransferase that modifies Notch

Notch receptors function in highly conserved intercellular signalling pathways that direct cell-fate decisions, proliferation and apoptosis in metazoans. Fringe proteins can positively and negatively modulate the ability of Notch ligands to activate the Notch receptor. Here we establish the biochemical mechanism of Fringe action. Drosophila and mammalian Fringe proteins possess a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that initiates elongation of O-linked fucose residues attached to epidermal growth factor-like sequence repeats of Notch. We obtained biological evidence that Fringe-dependent elongation of O-linked fucose on Notch modulates Notch signalling by using co-culture assays in mammalian cells and by expression of an enzymatically inactive Fringe mutant in Drosophila. The post-translational modification of Notch by Fringe represents a striking example of modulation of a signalling event by differential receptor glycosylation and identifies a mechanism that is likely to be relevant to other signalling pathways.     

基于XML的异构数据源集成查询中间件的设计和实现

企业ERP建设中形成了许多异构数据源,为了有效使用这些数据有必要进行异构数据源的集成.为此给出了基于XML的异构数据源集成查询的中间件的设计和实现方案.该中间件具有接收查询的功能,还具有对用户查询进行语法分析、生成查询任务树、优化查询、分解查询和组合数据并以XML格式保存信息的功能.     

液体动力润滑滑动轴承概率设计

为了最大限度地满足液体动力润滑径向滑动轴承的承载量系数值,以达到滑动轴承承载能力的要求,提出液体动力润滑径向滑动轴承概率设计的数学模型,并给出了具体的概率设计方法.实例计算结果表明,该方法实用、合理.     

不同天线相关分布特性下的MIMO容量性能分析

研究了在无线MIMO(Multiple-Input Multiple-Output)系统中,天线的相关性对系统容量性能的影响.建立了相关天线MIMO系统仿真模型,给出了相关系数并推导了相关信道容量的表达式,用Monte Carlo法仿真了天线角度扩展分别为高斯分布和均匀分布2种情况,对比分析了信道容量与天线角度扩展以及扩展分布特征之间的关系,为实际的MIMO系统设计提供参考.     

Estimation and prediction of black carbon emissions in Beijing City

Black carbon is a by-product of incomplete combustion of carbon containing fuels. It can alter atmospheric radiation property and make adverse impacts on human health. The energy consumption in Beijing City depends largely on coal burning. Recently, Beijing City has been performing the municipal energy structure adjustment as a tool for air pollution abatement, aiming at the air quality goal for the Beijing 2008 Olympic Games. Based on Beijing energy use data in 2000, combined with emission factors of major sources of black carbon, the emission of black carbon in Beijing City is estimated to be 7.77 Gg. Coke, raw coal and biomass as non-commercial energy are the main contributors to municipal black carbon emissions. Based on Beijing energy planning in the year 2008, the emission of black carbon in 2008 will be 2.97 Gg if the contribution from biomass is not taken into account. Assuming that the black carbon emission from rural biomass in 2008 is the same as that in 2004, the biomass burning will be the largest emitter of black carbon to Beijing City in 2008.     

Ecosystem vulnerability of China under B2 climate scenario in the 21st century

This paper applies climate change scenarios in China based on the SRES assumptions with the help of RCMs projections by PRECIS （providing regional climates for impacts studies） system introduced to China from.the Hadley Centre for Climate Prediction and Research at a high-resolution （50 kmx50 km） over China. This research focuses on B2 scenario of SRES. A biogeochemical model ＂Atmosphere Vegetation Integrated Model （AVIM2）＂ was applied to simulating ecosystem status in the 21st century. Then vulnerability of ecosystems was assessed based on a set of index of mainly net primary production （NPP） of vegetation. Results show that climate change would affect ecosystem of China severely and there would be a worse trend with the lapse of time. The regions where having vulnerable ecological background would have heavier impacts while some regions with better ecological background would also receive serious impacts. Extreme climate even would bring about worse impact on the ecosystems. Open shrub and desert steppe would be the two most affected types. When the extreme events happen, vulnerable ecosystem would extend to part of defoliate broad-leaved forest, woody grassland and evergreen conifer forest. Climate change would not always be negative. It could be of some benefit to cold region during the near-term. However, in view of mid-term to long-term negative impact on ecosystem vulnerability would be enormously.     

一种多线结构光测头的误差补偿方法

针对在多线结构光测量系统中光平面不等距和不平行引起测量误差的问题,提出了一种基于标准三角块的误差补偿方法.通过分析测量误差产生的原因,建立了光平面平行度、光平面间距与测量误差之间关系的数学模型,将测头产生的结构光条投射到一个标准三角块斜面上,利用三角块斜面的几何变换能力将光平面平行度、光平面间距的信息转换到系统可以进行精确测量的光平面当中.通过CCD采集和数学计算,可以得到准确的各光平面平行度和光平面间距的误差数据,并根据得到的误差数据对测得的原始数据进行补偿修正,由实验证明了该方法在对阵列式多线结构光测头结构误差补偿后,测量得到的数据精度可以提高约40%.     

硅基完全集成DC/DC转换器中多层平面电感设计与建模

为提高完全集成低压低功率DC／DC转换器转换效率与输出电流能力，提出了一种多层混联螺旋电感结构．该结构基于标准0．5μm 2P3M CMOS工艺，将下面较薄的两层金属线圈多点并联，再与最上层金属线圈串联．多点并联结构有效地增加了等效金属层的厚度，串联结构增加了线圈之间的互感值，从而可以在不增加额外工艺成本的条件下显著提高平面电感的品质因数、单位面积电感值和电感线圈的电流承受能力．所提出的模型为完全集成DC／DC转换器的整体电路模拟分析提供了便利基础．基于0．5μm2P3MCMOS硅衬底工艺的模拟计算结果表明，在DC／DC转换器工作频段50～400MHz，取得了预期电感的设计效果，最大品质因数值达4．2，单位面积电感值达到83mH／m^2，可以承受的电流达90mA．电感芯片测试结果与模型模拟结果基本吻合．     

产结晶纤维素酶的嗜热菌鉴定及其酶学性质

从云南腾冲热海温泉采集的样品中,分离出一株产结晶纤维素酶的嗜热菌TC-1.该菌株呈杆状,革兰氏阴性,生理生化特征分析和16S rDNA序列同源性比对表明它属于亚栖热菌属Meiothermus.结晶纤维素、木聚糖和葡萄糖可以诱导该菌产生结晶纤维素酶,其中结晶纤维素诱导的酶活力最高.对其产生的结晶纤维素酶进行了初步纯化与酶学性质研究,该酶的最适反应温度为70℃,最适pH为6.0,在50℃～70℃和pH5.5～6.5之间酶活力相对稳定.     

山西省镁工业污染防治现状与对策研究

介绍了国内外镁工业的发展与污染现状，针对山西省镁工业发展与污染的现状以及污染防治中存在的问题，提出了污染防治的对策措施。