Antagonistic effect of 6-hydroxydopamine (6-OHDA) on generation of immunosuppressive protein of stress in the rat

Neonatal rats were injected with 6-hydroxydopamine (6-OHDA) for chemical sympathectomy. The rats were treated with restraint stress when they grew up to 56 d. It has-been found that the generation of immunosuppressive protein of stress (ISPS) is significantly reduced, suggesting that peripheral sympathetic nerve plays an important role in mediating the generation of ISPS.     

格值正则语言的逼近性质

文章主要在格半群L=[0,1]上研究了格值正则语言的逼近性质,从覆盖、拟正定等方面给出了格值正则语言可被正则语言逼近的充分或必要条件.     

铁路系统的模型检查和参数分析

研究铁路系统的自动验证技术，建立火车和控制器的混合自动机模型，用时态逻辑ＩＣＴＬ描述铁路系统的性质规范，使用模型检查技术自动验证铁路系统，并且对铁路系统的一些参数进行分析。     

芥蓝(Brassica alboglabra Bailey)组培苗遗传稳定性的研究

对芥蓝（BrassicaalboglabraBailey）组培苗后代从个体形态特征、染色体数目、过氧化物酶同工酶进行分析研究，结果表明：组培第一代苗在外部形态上、产籽量等方面基本保持了原母株特征，染色体数目和过氧化物酶同工酶酶谱也与原母株相一致.     

Ranking effects of candidate drugs on biological process by integrating network analysis and Gene Ontology

There are high preclinical attrition rates in current drug discovery. The efficient assessment approach in the high throughout candidate drugs screening still needs great improvement. We propose two hypotheses. First, both drug action process and biological process can be converted to a common space of gene or gene product profiling. Second, the strength of drug action on biological process can be realized in the context of biological network. Based on the above hypotheses, we establish an algorithm termed Network-based Assessment for Drug Action (NADA) to assess the action strength of candidate drugs on certain biological processes. Then NADA is used to prioritize the effects of six compounds from traditional Chinese medicine on endothelial cell migration, a simple process defined by Gene Ontology, in the biological network specific for a given pathological process, angiogenesis. The computational results are subsequently tested by the experiment on the migration of Human Umbilical Vein Endothelial Cells in vitro. The experimental ranks for six compounds generally agree with the predicted output of NADA. NADA also outperforms the DAVID and meet/min methods in terms of the experimental orders, suggesting that the network topological features may have a key role in catching the mechanistic relationship between drug action and biological process. Hopefully, the progress of network biology approaches for deciphering complex diseases will further expedite the preclinical screening and accelerate the development of treatment modalities.     

Mn-ion-enhanced red spectral emission from yttrium aluminum garnet doped cerium phosphor

Mnions were co-doped in yttrium aluminum garnet doped cerium(YAG:Ce) phosphors as a co-activator and host lattice element using the co-precipitation method.These ions broadened the emission spectra of the pure YAG:Ce phosphor,which is caused by the 2E-4A2,5E-5T2 or 1T2-5T2 transition.From our X-ray diffraction results,we observed that Ce3+(1.032 ) was substituted at the Y3+(0.900 ) site,and Mn4+(0.538 ) and Mn3+(0.67 ) were substituted at the Al3+(0.535 ) site.The chromaticity color co-ordinates of YAG:Ce0.06 is(0.203,0.167),and the indices of YAG:Ce0.06,Mn0.04 and YAG:Ce0.06,Mn0.08 are(0.249,0.181) and(0.233,0.194),respectively.The manganese co-doped yttrium aluminum garnet doped cerium blended with the YAG:Ce phosphor showed improved white light emission.     

论法官聘任技术顾问的权力

法官能得到的技术支持不足以解决其审查科技证据时所面对的所有技术难题.为解决法官的困境,可以把海事法院聘任技术顾问的做法推广到其他法院.有些法院也正在进行这方面的探索.英美技术顾问制度的实践给我们提供了有益的经验.构建我国的技术顾问制度可以从技术顾问的职责、资格、选任前提、程序等方面着手.     

Phylogenetic position of three Condylostoma species(Protozoa,Ciliophora,Heterotricheal inferred from the small subunit rRNA gene sequence

The systematically poorly known ciliate genus Conadylostoma was erected by Vincent in 1826.About 10 morphotypes have been reported,but any molecular investigations concerning this group SO far are lacking.In this work,the small subunit ribosomal RNA (SS rRNA)gene of three marine Conaylostoma species was sequenced,by which the phylogenetic trees were constructed by distance-matrix,maximum parsimony and Bayesian inference methods.The results show that(1)all the trees have similar topologies with high supports;(2)Condylostoma is mostly related to the genus Condylostentor;and(3)three Condylostoma species as well as Conadylostentor auriculatus cluster together and form a sister group with other heterotrichs.This is moderately consistent with the assessment of phylo-genetic relationships of Conaylostoma-related heterotrichs from the morphological information.The phylogenetic relationship of some other related heterotrichs,Peritromus,Fotlictllina,Stentor and Blepharisma,has been also discussed.