MRS study on lentiform nucleus in idiopathic Parkinson‘s disease with unilateral symptoms

OBJECTIVE: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson's disease. METHODS: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), Creatine (Cr) and Choline (Cho) were calculated. RESULTS: Compared to that in the control, NAA/ (Cho+Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P<0.05); while there was no difference between the two sides in the healthy volunteer (P>0.05). The ratio of NAA/(Cho+Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P<0.05). CONCLUSIONS: There might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson's disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis.     

关于"教育强省"的思考

把四川建设成“西部教育强省”既是一个催人奋进的行动口号,又是实施西部大开发战略的重要组成部分。文章着重论述了建设教育强省提出的依据和背景,教育强省的内涵,界定教育强省的基本要求和主要标尺等问题。     

Systematic screen for human disease genes in yeast

High similarity between yeast and human mitochondria allows functional genomic study of Saccharomyces cerevisiae to be used to identify human genes involved in disease. So far, 102 heritable disorders have been attributed to defects in a quarter of the known nuclear-encoded mitochondrial proteins in humans. Many mitochondrial diseases remain unexplained, however, in part because only 40-60% of the presumed 700-1,000 proteins involved in mitochondrial function and biogenesis have been identified. Here we apply a systematic functional screen using the pre-existing whole-genome pool of yeast deletion mutants to identify mitochondrial proteins. Three million measurements of strain fitness identified 466 genes whose deletions impaired mitochondrial respiration, of which 265 were new. Our approach gave higher selection than other systematic approaches, including fivefold greater selection than gene expression analysis. To apply these advantages to human disorders involving mitochondria, human orthologs were identified and linked to heritable diseases using genomic map positions.     

一种基于视觉掩盖模型的数字水印技术

通过分析人的视觉特性提出一种视觉掩盖模型,得到该模型水印嵌入算法和水印检测算法。在DCT系统低频域上给典型的“Lena”图像嵌入水印后,进行压缩、加高斯噪声污染、滤波等试验,测试水印的稳健性。结果发现：水印输出响应非常高,有很好的鲁棒性,嵌入水印后的图像经一定的压缩、噪声污染、滤波等处理后仍可被检测到。     

国际互联网技术与旅游业企业过程重组

信息技术、互联网、通讯技术的发展引起了整个旅游业的一场革命,正在深刻地改变着旅游业的经营、管理和运作模式。网络技术的出现则恰好给旅游业的加速发展、企业过程重组带来了新的机遇。文章集中分析了旅游业的信息特征、信息技术、互联网技术引起的旅游业的经营环境变化,提出了旅游服务供应链管理的概念。在此基础上,结合英特网技术在旅游业的功能,提出了旅游业的企业过程重组,建立虚拟旅游公司模式。     

Adaptive terminal sliding mode control for high-order nonlinear dynamic systems

An adaptive terminal sliding mode control (SMC) technique is proposed to deal with the tracking problem for a class of high-order nonlinear dynamic systems. It is shown that a function augmented sliding hyperplane can be used to develop a new terminal sliding mode for high-order nonlinear systems. A terminal SMC controller based on Lyapunov theory is designed to force the state variables of the closed-loop system to reach and remain on the terminal sliding mode, so that the output tracking error then converges to zero in finite time which can be set arbitrarily. An adaptive mechanism is introduced to estimate the unknown parameters of the upper bounds of system uncertainties. The estimates are then used as controller parameters so that the effects of uncertain dynamics can be eliminated. It is also shown that the stability of the closed-loop system can be guaranteed with the proposed control strategy. The simulation of a numerical example is provided to show the effectiveness of the new method.     

Geochronology of source materials from high-pressure and ultrahigh-pressure metamorphic rocks in Jurassic sedimentary rocks of Hefei Basin

Eclogite cobbles were discovered by Wang et al. (2001) in the Fenghuangtai Formation of the northern margin of Dabie Mountains in the Dushan area of Anhui Province, China[1]. They proposed that after the formation during the Triassic, the high-pressure (HP) and ultra-high-pressure (UHP) metamorphic rocks reached the sur-face through exhumation and uplifting before the late Ju-rassic. However, they have not provided any evidence about isotopic ages. One kind of cobbles of HP-UHP rocks w…     

Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin

Small molecules such as NO, O2, CO or H2 are important biological ligands that bind to metalloproteins to function crucially in processes such as signal transduction, respiration and catalysis. A key issue for understanding the regulation of reaction mechanisms in these systems is whether ligands gain access to the binding sites through specific channels and docking sites, or by random diffusion through the protein matrix. A model system for studying this issue is myoglobin, a simple haem protein. Myoglobin has been studied extensively by spectroscopy, crystallography, computation and theory. It serves as an aid to oxygen diffusion but also binds carbon monoxide, a byproduct of endogenous haem catabolism. Molecular dynamics simulations, random mutagenesis and flash photolysis studies indicate that ligand migration occurs through a limited number of pathways involving docking sites. Here we report the 1.4 A resolution crystal structure of a ligand-binding intermediate in carbonmonoxy myoglobin that may have far-reaching implications for understanding the dynamics of ligand binding and catalysis.     

根溪河小流域高程和坡度对水土流失现状的影响

为了探讨福建省长汀水土流失严重的原因,选取地形因子中的高程和坡度,结合“3S”的空间分析技术,对根溪河小流域的水土流失现状进行分析.研究表明:流域内海拔为300～350m所占的面积最大,比例为34.06%,而坡度在25～35°之间的面积最大,占总面积的27.27%;海拔在300～400m之间,因人类活动频繁而又缺乏合理规划与保护措施,导致此区域内成为水土流失分布最广和最严重的地带,而坡度为15～20°的土壤侵蚀率最高.     

闽台土地利用时空格局对比研究

以闽台为研究对象，对两地土地利用时空格局进行对比研究，结果表明：从空间格局上看，闽台土地利用类型齐全，闽台两地皆以林地为主，耕地次之，各地类面积和区域差异较大.福建的林地、未利用土地面积比重高于台湾，耕地、建设用地相反.福建林地比重由西向东，由北往南逐渐减少，台湾反之，福建耕地及建设用地比重由西向东、由北往南逐渐增加，而台湾则由东向西，由南北往中部依次上升;从时间变化上看，闽台耕地均以递减为主，闽台建设用地均以递增为主.