Frequent mtDNA mutations and its role in gastric carcinogenesis

In order to disclose the relationship between mutations of mitochondrial DNA (mtDNA) and gastric carcinogenesis, we screened the entire mtDNA sequence in 30 cases of human gastric cancer and matched normal tissues by using denaturing high-performance liquid chromatography (DHPLC) and DNA sequencing. Our data showed that high frequency (66.7%, 20/30) of mitochondrial genome mutation occurred in gastric cancer. Among these variants, 17 cases (56.7%, 17/30) were identified to be somatic mutation. High level mutant frequency was found in ND4, ND5 coding genes and D-loop control region, which was 36.7%, 26.7% and 30% respectively. Comparing with complexes Ⅲ, Ⅳ and Ⅴof the electron transport chain, we found that variants appeared to be more frequent in the subunit genes of complexⅠ. Most of mutations were base substitutions (85.4%, 41/48). Our results suggested that mutations of subunit genes encoding complexⅠ, especially ND3, ND4 and ND5 genes, might contribute to human gastric carcinogenesis.     

具有随机偏差的最优多段卡尔曼估值器

提出了具有随机偏差的最优多段卡尔曼估值器。针对状态模型与观测模型同时具有偏差且偏差模型噪声与状态模型噪声相关的情况 ,给出了具有随机偏差的状态方程的增广状态 ,并通过U V变换对卡尔曼估值器的协方差矩阵解耦得到了最优多段卡尔曼估值器。结果表明 ,多段卡尔曼估值器不仅是最优的 ,而且降低了计算的复杂度     

一些特殊树的对偶带宽

图G的对偶带宽是指图G中相邻两点最小标号差的最大值。确定了一些特殊树的对偶带宽，主要结果如下：(1)如果树T有n个顶点，并且其最大度△(T)不小于[n/2]，那么树T的对偶带宽等于n一△(T)的充要条件为T是双层星且其内星的中心为最大度顶点；(2)完全二叉树T2,k的对偶带宽等于2^k-1；(3)等高单毛虫树Pm,n的对偶带宽为[mn/2]。     

Discovering Frequent Subtrees from XML Data Using Neural Networks

By rapid progress of network and storage technologies, a huge amount of electronic data such as Web pages and XML has been available on Internet. In this paper, we study a data-mining problem of discovering frequent ordered sub-trees in a large collection of XML data, where both of the patterns and the data are modeled by labeled ordered trees. We present an efficient algorithm of Ordered Subtree Miner （OSTMiner） based on two- layer neural networks with Hebb rule, that computes all ordered sub-trees appearing in a collection of XML trees with frequent above a user-specified threshold using a special structure EM-tree. In this algo- rithm, EM-tree is used as an extended merging tree to supply scheme information for efficient pruning and mining frequent sub-trees. Experiments results showed that OSTMiner has good response time and scales well.     

历史时期(1797-1958)西藏雹霜虫灾述论

文章依据已整理出版的西藏《灾异志.雹霜虫灾篇》一百一十五份档案资料,从历史时期(1797—1958)西藏雹霜虫灾发生的地理分布入手进行研究。讨论范围涉及历史时期西藏雹霜虫灾与气候的关系、呈现的特征及其政府的赈灾问题等,试图从不同的角度勾勒出历史时期西藏雹霜虫灾的大致轮廓。     

30MnNbXt钢组合匹配接头性能的研究

本文为新钢种30MnNbXt设计了一种独特的组合匹配接头,研究了底层奥氏体焊条的合金系统及填充层结构钢焊条的强度对抗裂性的影响,探讨了底层高组配、填充层低组配的组合匹配焊缝特征区的组织特点及接头的力学性能。在西德WS1.7—2.0/3.5型综采支架立柱中应用表明,组合匹配接头可使30MnNbXt钢在室温下焊接时不产生裂纹;接头在焊后状态的使用性能完全符合产品技术条件要求。     

胆固醇与人体健康

本文论述了人体内胆固醇的分布、主要生理功能、血胆固醇含量与动脉粥样硬化等疾病的关系,同时还介绍了降低血胆固醇含量的途径和措施.     

次线性算子与幂权的Soria－Weiss定理的拓广

将次线性算子关于测度｜Ｘ｜－ａｄｘ的（ｐ，ｐ）型的Ｓｏｒｉａ－Ｗｅｉｓｓ定理拓广到非光滑核算子的情形中去，而且关于ａ的范围是准确的。     

投掷球出手速度测试仪的进一步开发

通过对仪器测速过程的进一步分析,提出了一种新的数据处理方法。此方法可消除原方法所引入的随机误差,并能得到投掷球出手速度的方向和出手高度。采用新方法后,可使仪器结构进一步简化,能降低传感器制造成本30％。     

浅析普通机床的数控改造

论述了普通机床数控改造的可行性、必要性和经济性，并对C620-1型普通机床的数控改造过程进行了较详细的总结和论述，对普通机床的数控改造具有实际的指导作用。