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111.
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis 总被引:1,自引:0,他引:1
Khor CC Chapman SJ Vannberg FO Dunne A Murphy C Ling EY Frodsham AJ Walley AJ Kyrieleis O Khan A Aucan C Segal S Moore CE Knox K Campbell SJ Lienhardt C Scott A Aaby P Sow OY Grignani RT Sillah J Sirugo G Peshu N Williams TN Maitland K Davies RJ Kwiatkowski DP Day NP Yala D Crook DW Marsh K Berkley JA O'Neill LA Hill AV 《Nature genetics》2007,39(4):523-528
Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6). We report a case-control study of 6,106 individuals from the UK, Vietnam and several African countries with invasive pneumococcal disease, bacteremia, malaria and tuberculosis. We genotyped 33 SNPs, including rs8177374, which encodes a leucine substitution at Ser180 of Mal. We found that heterozygous carriage of this variant associated independently with all four infectious diseases in the different study populations. Combining the study groups, we found substantial support for a protective effect of S180L heterozygosity against these infectious diseases (N = 6,106; overall P = 9.6 x 10(-8)). We found that the Mal S180L variant attenuated TLR2 signal transduction. 相似文献
112.
Study on the impact force and green properties of high-velocity compacted aluminum alloy powder 下载免费PDF全文
High-velocity compaction (HVC) provides an effective means in the field of powder metallurgy (P/M) to reduce the porosity as well as to ameliorate the mechanical properties of products. In this study, the green density of an aluminum alloy is found to be 2.783 g·cm-3. The ejection force for the aluminum alloy is in the range of 23 to 80 kN and the spring back is found to be less than 0.40%. The hardness of the green body is in the range of HRB 30 to 70. The bending strength of the green body is in the range of 6 to 26 MPa, which are higher than that of other aluminum alloys prepared by the traditional compaction method. 相似文献
113.
Mavrakis KJ Van Der Meulen J Wolfe AL Liu X Mets E Taghon T Khan AA Setty M Setti M Rondou P Vandenberghe P Delabesse E Benoit Y Socci NB Leslie CS Van Vlierberghe P Speleman F Wendel HG 《Nature genetics》2011,43(7):673-678
The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene interactions in this cancer. 相似文献
114.
Rubber rabbitbrush ( Chrysothamnus nauseosus [Pallas] Britt. ssp. viridulus ) may prove to be a source of high-quality cis-isoprene rubber, but its establishment is limited by a lack of information on seed germination. Consequently, seeds were germinated at alternating temperatures (5–15, 5–25, 15–25, and 20–30 C) in light and dark as well as constant temperatures (15–40 C with 5-C increments) to determine temperature response. Seeds were also germinated in solutions of polyethylene glycol 6000 (0 to –5 bar), salinity regimes (1, 17, 51, and 86 mM) at all the above-mentioned temperatures to determine salinity and temperature interaction. The hormones GA 3 (0, 2.9, 29.0, and 58.0 um) and kinetin (0, 4.7, 23.5, and 47.0 um) were used to study their effect on overcoming salt- and temperature-induced germination inhibition. Seeds of C. nauseosus ssp. viridulus were very sensitive to low temperature. Best germination was achieved at 25 and 30 C, but these seeds also germinated at a higher temperature (35 C). The seeds of rabbitbrush germinated at both constant and alternating temperatures. Light appears to play little or no role in controlling germination of the seeds of rubber rabbitbrush. However, seeds of rabbitbrush were sensitive to salinity, and seed germination was progressively inhibited by increase in salt concentration, although a few seeds still germinated at the highest saline level. Progressively higher concentrations of polyethylene glycol also progressively inhibited germination. Suppression of seed germination induced by high salt concentrations and high temperatures can be partially alleviated by the application of either GA 3 or kinetin. 相似文献
115.
116.
车辆悬架系统的自适应模糊控制(英文) 总被引:1,自引:0,他引:1
悬架是用来支持车身的系统,通过隔离道路干扰使得乘客感觉舒适、并确保车辆稳定.为此研究了全车模型悬架系统在下列几种控制方式下的性能:被动控制、半主动控制、自适应标准可加性模型(SAM)下的主动控制.全车模型可以为车辆悬架系统提供一些必要的性能参数,如车身偏移、车轮偏移和悬架偏斜.乘坐的舒适性和车辆的操控性决定了所需悬架系统的性能.乘坐的舒适性取决于车身偏移和乘客座位的偏移,而车辆的稳定由其他自由度(如俯仰和滚转)决定.半主动和主动悬架控制的设计通过MATLAB/SIMULINK加以实现,充分考虑了不规则的路面,并以此验证半主动控制和SAM主动控制的性能.实验结果表明,SAM主动控制能够改善乘坐的舒适性和车辆的操控性. 相似文献
117.
Caitlin Collin Frank Hauser Ernesto Gonzalez de Valdivia Shizhong Li Julia Reisenberger Eva M. M. Carlsen Zaid Khan Niels Ø. Hansen Florian Puhm Leif Søndergaard Justyna Niemiec Magdalena Heninger Guilin R. Ren Cornelis J. P. Grimmelikhuijzen 《Cellular and molecular life sciences : CMLS》2013,70(17):3231-3242
Muscarinic acetylcholine receptors (mAChRs) play a central role in the mammalian nervous system. These receptors are G protein-coupled receptors (GPCRs), which are activated by the agonists acetylcholine and muscarine, and blocked by a variety of antagonists. Mammals have five mAChRs (m1–m5). In this study, we cloned two structurally related GPCRs from the fruit fly Drosophila melanogaster, which, after expression in Chinese hamster ovary cells, proved to be muscarinic acetylcholine receptors. One mAChR (the A-type; encoded by gene CG4356) is activated by acetylcholine (EC50, 5 × 10?8 M) and muscarine (EC50, 6 × 10?8 M) and blocked by the classical mAChR antagonists atropine, scopolamine, and 3-quinuclidinyl-benzilate (QNB), while the other (the B-type; encoded by gene CG7918) is also activated by acetylcholine, but has a 1,000-fold lower sensitivity to muscarine, and is not blocked by the antagonists. A- and B-type mAChRs were also cloned and functionally characterized from the red flour beetle Tribolium castaneum. Recently, Haga et al. (Nature 2012, 482: 547–551) published the crystal structure of the human m2 mAChR, revealing 14 amino acid residues forming the binding pocket for QNB. These residues are identical between the human m2 and the D. melanogaster and T. castaneum A-type mAChRs, while many of them are different between the human m2 and the B-type receptors. Using bioinformatics, one orthologue of the A-type and one of the B-type mAChRs could also be found in all other arthropods with a sequenced genome. Protostomes, such as arthropods, and deuterostomes, such as mammals and other vertebrates, belong to two evolutionarily distinct lineages of animal evolution that split about 700 million years ago. We found that animals that originated before this split, such as cnidarians (Hydra), had two A-type mAChRs. From these data we propose a model for the evolution of mAChRs. 相似文献
118.
119.
Sajjad Ali Yaseen Iqbal Inamullah Khan Ansar Ullah Muhammad Sadiq Muhammad Fahad Khizar Hussain Shah 《矿物冶金与材料学报》2021,28(2):193-200
Manganese was leached from a low-grade manganese ore (LGMO) using banana peel as the reductant in a dilute sulfuric acid medium. The effects of banana peel amount, H2SO4 concentration, reaction temperature, and time on Mn leaching from the complex LGMO were studied. A leaching efficiency of ~98% was achieved at a leaching time of 2 h, banana peel amount of 4 g, leaching temperature of 120°C, manganese ore amount of 5 g, and sulfuric acid concentration of 15vol%. The phase, microstructural, and chemical analyses of LGMO samples before and after the leaching process confirmed the successful leaching of manganese. Furthermore, the leaching process followed the shrinking core model and the leaching rate was controlled by a surface chemical reaction (1 ? (1 ? x)1/3 = kt) mechanism with an apparent activation energy of 40.19 kJ·mol?1. 相似文献
120.
R. Khan S. Burton S. Morley S. Daya B. Potgieter 《Cellular and molecular life sciences : CMLS》1990,46(1):88-89
Summary Prior melatonin administration (1,5 and 10 mg/kg b. wt) causes a significant reduction in gastric ulceration induced in male rats by restraint immobilization in the presence of low temperatures. 相似文献