EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa

Using a positional cloning approach supported by comparative genomics, we have identified a previously unreported gene, EYS, at the RP25 locus on chromosome 6q12 commonly mutated in autosomal recessive retinitis pigmentosa. Spanning over 2 Mb, this is the largest eye-specific gene identified so far. EYS is independently disrupted in four other mammalian lineages, including that of rodents, but is well conserved from Drosophila to man and is likely to have a role in the modeling of retinal architecture.     

Suitable energy platform significantly improves charge separation of g-C_3N_4 for CO_2 reduction and pollutant oxidation under visible-light

The photocatalytic activities of g-C_3N_4 can be significantly improved by increasing life time of the photogenerated charges. Here, in this work we introduced TiO_2 as proper energy platform to accept the photogenerated electrons from g-C_3N_4 during photocatalysis. The nanophotocatalysts formed from the combination of a suitable amount of TiO_2 nanoparticles and g-C_3N_4 nanosheets showed 8.75 and 4.22% enhancement in photocatalytic activities for CO_2 reduction and 2-chlorophenol(2-CP) degradation under visible light illumination as compared to bare g-C_3N_4. Based on the surface photovoltage spectra, photoluminescence spectra and examination of formed hydroxyl radicals, it was confirmed that these enhanced photoactivities were attributed to the much-improved charge separation via the electron transfer from g-C_3N_4 to TiO_2. From trapping experiments,it was found that hydroxyl radicals were the major species involved in the photocatalytic degradation of 2-CP.This study is helpful to synthesize efficient photocatalysts to cope with energy and environmental issues.     

Tunability of physical properties of (Cd:Zn)S thin film by Close Space Sublimation Process (CSSP)

The present paper reports on a systematic study of the influence of Zn alloying on the structural and optical properties of Cd1 xZnxS thin films. X-ray diffraction study for structural analysis reveals that the two binary compounds have been completely transformed into ternary compound with hexagonal (wurtzite) structure with preferred orientation along c-direction with (002) planes. The optical properties such as optical constants and band gap energy of the films were examined by using spectroscopic ellipsometer and Photospectrometery. It was found that the optical constants (n and k) decrease with the addition of Zn content in the alloy. It was also confirmed that the band gap increases with increasing Zn amount in the alloy and is attributed to quantum size effect in the grain size. Raman spectroscopy analysis shows one dominant phonon band at 326 cm 1, the so-called longitudinal optical (LO) mode for all the alloy composition (x). The appearance of a single phonon band in the Raman spectra established the formation of single phase hexagonal structured Cd1 xZnxS thin film. The LO band is asymmetrically broaden and high frequency shifted due to potential fluctuation caused by the dopant material. The AFM results showed that the surface roughness was decreased with increasing Zn content.     

Ammonia borane at high pressures

Ammonia borane has received tremendous research attention in the past decade because of its potential for chemical hydrogen storage. This paper reviews recent studies about the behavior of ammonia borane at high pressures. While much work is still needed to comprehensively understand the pressure influence on this molecular crystal, a phase diagram based on the available experimental and theoretical data is constructed. Raman spectroscopy studies indicate five transitions upon compression up to 65 GPa at ambient temperature. Diffraction experiments and theoretical studies demonstrate that three of these transitions are first-order phase transformations in the sequence of I4mm-Cmc21-P21-（different） P21, and two are iso-structural. A low-temperature phase（Pmn21） and a high-temperature high-pressure phase（Pmna） are also recognized.     

考虑震损的混凝土框架结构改进建模方法

为准确描述震后结构损伤的影响,提出了损伤构件的定量分析方法及震损结构的改进建模方法.首先,从骨架曲线退化及滞回规则退化两方面定义了损伤构件的性能退化指数;然后,基于Park-Ang模型与Kunnath模型,采用统计回归分析方法提出了损伤构件恢复力模型,并对其准确性进行了验证;最后,应用该恢复力模型对震损框架结构进行弹塑性分析.结果 表明:采用Park-Ang模型和Kunnath模型得到的损伤构件恢复力模型均具有较高的准确性;对于所研究的2种构件,滞回曲线力峰值的理论值和试验值误差均小于10％;向完好结构输入组合地震波,向震损结构输入单一地震波,各层位移时程曲线吻合良好,说明采用该恢复力模型进行震损结构建模能够准确分析震损程度及分布对结构抗震性能的影响.     

Selection of Value‐at‐Risk models

Value‐at‐Risk (VaR) is widely used as a tool for measuring the market risk of asset portfolios. However, alternative VaR implementations are known to yield fairly different VaR forecasts. Hence, every use of VaR requires choosing among alternative forecasting models. This paper undertakes two case studies in model selection, for the S&P 500 index and India's NSE‐50 index, at the 95% and 99% levels. We employ a two‐stage model selection procedure. In the first stage we test a class of models for statistical accuracy. If multiple models survive rejection with the tests, we perform a second stage filtering of the surviving models using subjective loss functions. This two‐stage model selection procedure does prove to be useful in choosing a VaR model, while only incompletely addressing the problem. These case studies give us some evidence about the strengths and limitations of present knowledge on estimation and testing for VaR. Copyright © 2003 John Wiley & Sons, Ltd.     

An AI Embedded Object-Oriented Approach for Formulating Computable General Equilibrium

1.INTRODUCTIONOneofthemajoradvancementinappliedeconomicssince1970sistheconversionofthewellknownWalrasiangeneralequilibriumstructurefromanabstractrepreselltationofaneconomyintorealisticmodelsofactualeconomies.Theconversion,knownascomputablegeneralequilibrium(CGE)modeling,isdonebyendowingthesystemofwell-specifieddemandandsupplyequationswithempiricalcontentsandcomputationalgorithms.Withincreasingcomputerpower,thecomputablegeneralequilibriumanalysishasgraduallybecomeaverycompetitionanalytica…     

稀土元素多元杂多配合物振动光谱的研究

稀土元素含钼杂多酸根配合物,含钼、钨杂多酸根配合物,以及钒、钼或钨混合多元杂多酸根配合物,共100余种,首次被合成出来。测定了它们的 IR 光谱,通过与相应的 Keggin 结构和 Dawson 结构的 IR 光谱比较,对某些主要谱带进行指认,讨论了它们的特征与变化规律。     

Effect of spermine on adenyl cyclase activity of spermatozoa

Zusammenfassung Zusätze physiologischer Sperminkonzentrationen (2–14 mM) zu menschlichen Spermiensuspensionen bewirken eine Steigerung der Adenylcyclase-Aktivität, wie sie durch die vermehrte Bildung von cAMP aus ATP angezeigt wird.