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lambda Repressor and cro--components of an efficient molecular switch 总被引:48,自引:0,他引:48
In a lysogen, most genes of phage lambda are repressed; in response to a transient induction signal, they are efficiently switched on. The switch, which consists in part of a tripartite operator to which two regulatory proteins bind, depends not only on DNA--protein interactions, but also on effects transmitted from one DNA-bound protein to another. lambda Exemplifies a strategy that facilitates efficient switching between two physiological states in response to a transient signal. 相似文献
997.
Schulz KG Zondervan I Gerringa LJ Timmermans KR Veldhuis MJ Riebesell U 《Nature》2004,430(7000):673-676
The deposition of atmospheric dust into the ocean has varied considerably over geological time. Because some of the trace metals contained in dust are essential plant nutrients which can limit phytoplankton growth in parts of the ocean, it has been suggested that variations in dust supply to the surface ocean might influence primary production. Whereas the role of trace metal availability in photosynthetic carbon fixation has received considerable attention, its effect on biogenic calcification is virtually unknown. The production of both particulate organic carbon and calcium carbonate (CaCO3) drives the ocean's biological carbon pump. The ratio of particulate organic carbon to CaCO3 export, the so-called rain ratio, is one of the factors determining CO2 sequestration in the deep ocean. Here we investigate the influence of the essential trace metals iron and zinc on the prominent CaCO3-producing microalga Emiliania huxleyi. We show that whereas at low iron concentrations growth and calcification are equally reduced, low zinc concentrations result in a de-coupling of the two processes. Despite the reduced growth rate of zinc-limited cells, CaCO3 production rates per cell remain unaffected, thus leading to highly calcified cells. These results suggest that changes in dust deposition can affect biogenic calcification in oceanic regions characterized by trace metal limitation, with possible consequences for CO2 partitioning between the atmosphere and the ocean. 相似文献
998.
Apart from echolocation and the pursuit of prey by bats, the function of ultrasound in animal communication is poorly understood. This is mainly because of the broad range of responses that it can evoke and the widely varied contexts in which it is used (for example, in rodents of the Muridae family it may indicate distress in infants or a sexual or predatory encounter in adults). Here we find that a purely ultrasonic signal is produced in the wild by a rodent of the Sciuridae family, Richardson's ground squirrel, and show that its function is to warn conspecifics of impending danger. To our knowledge, ultrasonic alarm calls have not previously been detected in any animal group, despite their twin advantages of being highly directional and inaudible to key predators. 相似文献
999.
Much of the progress in understanding gamma-ray bursts (GRBs) has come from studies of distant events (redshift z approximately 1). In the brightest GRBs, the gamma-rays are so highly collimated that the events can be seen across the Universe. It has long been suspected that the nearest and most common events have been missed because they are not as collimated or they are under-energetic (or both). Here we report soft gamma-ray observations of GRB 031203, the nearest event to date (z = 0.106; ref. 2). It had a duration of 40 s and peak energy of >190 keV, and therefore appears to be a typical long-duration GRB. The isotropic gamma-ray energy of < or =10(50) erg, however, is about three orders of magnitude smaller than that of the cosmological population. This event--as well as the other nearby but somewhat controversial GRB 980425--is a clear outlier from the isotropic-energy/peak-energy relation and luminosity/spectral-lag relations that describe the majority of GRBs. Radio calorimetry shows that both of these events are under-energetic explosions. We conclude that there does indeed exist a large population of under-energetic events. 相似文献
1000.
Dunham A Matthews LH Burton J Ashurst JL Howe KL Ashcroft KJ Beare DM Burford DC Hunt SE Griffiths-Jones S Jones MC Keenan SJ Oliver K Scott CE Ainscough R Almeida JP Ambrose KD Andrews DT Ashwell RI Babbage AK Bagguley CL Bailey J Bannerjee R Barlow KF Bates K Beasley H Bird CP Bray-Allen S Brown AJ Brown JY Burrill W Carder C Carter NP Chapman JC Clamp ME Clark SY Clarke G Clee CM Clegg SC Cobley V Collins JE Corby N Coville GJ Deloukas P Dhami P Dunham I Dunn M Earthrowl ME Ellington AG 《Nature》2004,428(6982):522-528
Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb. 相似文献