Synthese der razemischen Eleutherin-Chinone

Summary The synthesis of (±)-Eleutherine and (±)-Isoeleutherine is described.      

MammalianX-chromosomes: A new kind of composite-typeX in the voleArvicola scherman exitus miller

Zusammenfassung Autoradiographische Untersuchungen mit H³-Thymidin deckten bei der WühlmausA. scherman exitus (2n = 36) eine ungewöhnliche Geschlechtschromosomensituation auf. DasX-Chromosom misst 6,8% von (nA + X). Sein funktioneller Anteil ist zweigeteilt, daneben verfügt es über einen strukturell heterochromatischen und einen stets euchromatisch bleibenden Anteil. DasY ist für ein Säugetier aussergewöhnlich gross (2/3 desX).

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This investigation was in part supported by the Swiss National Foundation and for M.F.L. by the Roche-Studien-Stiftung.     

A low molecular weight glycosaminoglycan from the human aorta

Summary A low mol.wt, dialyzable glycosaminoglycan was isolated from human aorta and was found to be homogeneous on 2 dimensional electrophoresis. As judged by its electrophoretic mobilities and its hydrolysis by chondroitin sulfatase ABC, it was concluded that this hitherto unknown glycosaminoglycan is an oversulfated chondroitin sulfate.This study was supported by grants from the National Institutes of Health (GM-10374, HL-13262), U.S. Public Health Service.     

Zur Biosynthese des Cantharidins. I

Summary In contrast to the female, the adult males ofLytta vesicatoria (Coleopt. Meloidae) produced radioactive cantharidine on injection with¹⁴C-1-acetate and¹⁴C-2-mevalonate solutions. A partial degradation of the cantharidine showed that in the acetate experiment approximately of the activity occurred at C atoms 2 + 3 whereas with mevalonate approximately of the activity was at C atoms 8 + 9 and at C atoms 10 + 11. These results show that cantharidine is not formed by a tail to tail linkage of 2 isoprene units.

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Wir danken dem Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung für die Unterstützung dieser Arbeit, Herrn Dr.J. Würsch (Physikalisch-chemische Abteilung der Firma F. Hoffmann-La Roche & Co. AG, Basel) für¹⁴C-2-Mevalolacton und unserer mikroanalytischen Abteilung (LeitungH. Frohofer) für die Aktivitätsbestimmungen.     

Emergence of adult pandora moths in Arizona

Adult pandora moths began emerging in late July, and peak daily emergence occurred during 10–15 August. The mean density of moths emerging per 929 cm 2 of ground surface ranged from 0.1 to 2.4. The ratio of emerging males to females varied from 3–4:1 during the initial days of emergence to 1:1.5 during the last 10 days of August. Postemergence behavior is described and discussed in relation to egg mass deposition and species survival.         

A microbial metabolite of TCDD

Summary In the present study we describe the occurrence of a metabolite of TCDD, which arose in several microbial cultures after long term incubation. The polar metabolite amounted approximately 1% of the input material, and was found to be a hydroxylated derivative of TCDD.The work was supported by a grant from the Swiss Federal Government to R.H. and M.P. We thank Dr K. Grob, GC-Laboratory ETH Zürich, Dübendorf, Switzerland, for providing the highly inert column used in this work, and H.-R. Buser, Swiss Federal Research Station, Wädenswil, Switzerland, for his help in the analysis of the¹⁴C-TCDD.     

Purification and partial characterization of a human plasma α1-heteroglycan

Summary A heteroglycan was purified from human plasma and partially characterized in terms of its major properties. It is noteworthy that the carbohydrate content of this blood constituent is unusually high (75%).This study was supported by grants from the National Institutes of Health (GM-10374), US Public Health Service.