Whole-genome sequencing of multiple Arabidopsis thaliana populations

The plant Arabidopsis thaliana occurs naturally in many different habitats throughout Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse environments, a 1001 Genomes Project to sequence geographically diverse A. thaliana strains has been initiated. Here we present the first phase of this project, based on population-scale sequencing of 80 strains drawn from eight regions throughout the species' native range. We describe the majority of common small-scale polymorphisms as well as many larger insertions and deletions in the A. thaliana pan-genome, their effects on gene function, and the patterns of local and global linkage among these variants. The action of processes other than spontaneous mutation is identified by comparing the spectrum of mutations that have accumulated since A. thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations.     

Common sequence variants on 20q11.22 confer melanoma susceptibility

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.     

Zur Biosynthese des Plumierids

Summary It has been shown that the leaves ofPl. acutifolia incorporate acetate-1-¹⁴C and mevalonate-2-¹⁴C specifically for the formation of the aglycone moiety of plumieride.

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Wir danken dem Schweizerischen Nationalfonds sehr für die Unterstützung der Arbeit, Herrn Dr.J. Würsch (F. Hoffmann-La Roche & Cie., Basel) für markiertes Mevalonsäure-lakton und Herrn Prof.D. Arigoni (Zürich) für interessante Diskussionen.     

Zur Biosynthese des Verbenalins und Aucubins

Summary Verbena officinalis specifically incorporates 2-¹⁴C labelled mevalonic acid in the formation of the aglycone moiety of verbenalin (2). In aucubin (6), isolated fromVerbascum thapsus, the incorporation rate is very low and the main part of the activity is located in the sugar moiety.     

Continuous registration of the pancreatic blood flow after intravenous application of glucose

Zusammenfassung Die Hyperglykämie nach einmaliger stossartiger Glukoseinjektion bewirkt einen Durchblutungsanstieg der Bauchspeicheldrüse. Dieser wurde kontinuierlich mit einem elektromagnetischen Blutstrommesser bei narkotisierten Hunden registriet. Der Anstieg setzt sich aus 2 Abschnitten zusammen, wovon der erste unspezifisch auch in der A. femoralis auftritt.     

On the percutaneous absorption of tribenoside applied topically to the mouse ear

Zusammenfassung Mit Hilfe von radioaktiv markierten Präparaten (6-Benzyl-C¹⁴ bzw. 6-Furanose-H³) wird gezeigt, dass auf die Haut appliziertes Äthyl-3,5,6-tri-O-benzylglucofuranosid (Glyvenol^®) bei der Maus gut resorbiert wird.