不对称刻纹光纤传感阵列及其神经网络处理

描述了一种适用于机敏材料及其结构中应力、应变等状态探测与损伤估计的新颖的光纤传感阵列，采用的是周期性不对称刻纹多光纤组成的传感阵列，探讨了其信号的神经网络处理方法，给出了ＢＰ网的仿真结果。     

Glucose does not influence the insulin-like growth factor (IGF) binding to carrier proteins (IGFBPs): Analysis of rat and human serum by western ligand blotting

The insulin-like growth factors (IGFs) circulate bound to specific proteins (termed IGFBP-1 through IGFBP-6) that modulate IGF bioactivity in tissues. The aim of this study was to analyse the effects of glucose on IGF binding to IGFBPs in rat and human serum by means of western ligand blotting. Serum samples were incubated with increasing concentrations of glucose (0 to 50 mmol/l), and EDTA (25 mmol/l) was added to inhibit protease activity. To analyse the effect of glucose on protection of IGFBPs from protease activity, serum from pregnant women (reported to be very rich in proteolytic activity against IGFBPs) was added to rat serum previously incubated with glucose. Glucose did not affect the¹²⁵I-IGF binding to rat and human serum IGFBPs. The intensity of IGFBP-3 bands decreased considerably during the incubation. This appeared to be due to endogenous protease activity, since the decrease was blocked by addition of EDTA. The incubationi of rat serum with pregnant human serum produced a marked attenuation of IGFBP-3 and disappearance of IGFBP-4 bands. In conclusion, our study shows that glucose does not influence the IGF binding to IGFBP-3 either in rat or in human serum, confirms the presence of endogenous proteolytic activity in normal non-pregnant serum, and demonstrates that glucose has no protective action against protease activity.     

Occurrence and significance of prist-1-ene in kerogen pyrolysates

A SERIES of acylic isoprenoid alkanes, of which pristane and phytane are typical, frequently occurs in crude oils, shales, coals, bitumens and so on. It is generally agreed that the primary source of these compounds is the phytyl side chain of chlorophyll(1,2) although the mechanisms of its incorporation into sediments and its subsequent diagenesis, are not completely understood. At present, little is known about the role of kerogen as a source, or sink, of isoprenoid moieties and we report here that the principal isoprenoid, obtained by the high temperature (600 degrees C) pyrolysis of kerogens has been identified as prist-1-ene.     

Effects of acoustic waves on stick-slip in granular media and implications for earthquakes

It remains unknown how the small strains induced by seismic waves can trigger earthquakes at large distances, in some cases thousands of kilometres from the triggering earthquake, with failure often occurring long after the waves have passed. Earthquake nucleation is usually observed to take place at depths of 10-20 km, and so static overburden should be large enough to inhibit triggering by seismic-wave stress perturbations. To understand the physics of dynamic triggering better, as well as the influence of dynamic stressing on earthquake recurrence, we have conducted laboratory studies of stick-slip in granular media with and without applied acoustic vibration. Glass beads were used to simulate granular fault zone material, sheared under constant normal stress, and subject to transient or continuous perturbation by acoustic waves. Here we show that small-magnitude failure events, corresponding to triggered aftershocks, occur when applied sound-wave amplitudes exceed several microstrain. These events are frequently delayed or occur as part of a cascade of small events. Vibrations also cause large slip events to be disrupted in time relative to those without wave perturbation. The effects are observed for many large-event cycles after vibrations cease, indicating a strain memory in the granular material. Dynamic stressing of tectonic faults may play a similar role in determining the complexity of earthquake recurrence.     

基于驾驶员眼动分析的事故多发点改造方案评价方法研究

对事故多发点进行改造是减少事故的发生、增强交通安全的重要措施。其中增加标志标线等交通安全设施是常见的改造方式。由于驾驶行为是影响交通安全的重要因素,因此有必要从驾驶员角度对改造效进行评价。研究了某二级公路的事故多发点特点。在现场实验的基础上结合驾驶员眼动注视点的特征分析,分别从驾驶员注视特征、运营速度、改造前后的事故分析,综合评价事故多发点的改造效果。同时分析驾驶员负荷特征,为未来事故多发点的安全改造方案提出可行建议。     

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is critical for cellular growth and metabolism. Correspondingly, loss of function of PTEN, a negative regulator of PI3K, or activating mutations in AKT1, AKT2 or AKT3 have been found in distinct disorders featuring overgrowth or hypoglycemia. We performed exome sequencing of DNA from unaffected and affected cells from an individual with an unclassified syndrome of congenital progressive segmental overgrowth of fibrous and adipose tissue and bone and identified the cancer-associated mutation encoding p.His1047Leu in PIK3CA, the gene that encodes the p110α catalytic subunit of PI3K, only in affected cells. Sequencing of PIK3CA in ten additional individuals with overlapping syndromes identified either the p.His1047Leu alteration or a second cancer-associated alteration, p.His1047Arg, in nine cases. Affected dermal fibroblasts showed enhanced basal and epidermal growth factor (EGF)-stimulated phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) generation and concomitant activation of downstream signaling relative to their unaffected counterparts. Our findings characterize a distinct overgrowth syndrome, biochemically demonstrate activation of PI3K signaling and thereby identify a rational therapeutic target.     

印刷体藏文识别技术

藏文字符识别是中国的多文种信息处理系统的重要组成部分,本文论述了印刷体藏文识别系统的原理和预处理、识别、后处理过程,分析了文字识别的常用方法及其优缺点和印刷体藏文识别技术,着重分析了印刷体藏文识别中特征提取和分类器设计这两个关键技术,并对藏文识别研究领域今后的研究方向和发展前景提出了自己的看法.     

加快推进民族地区城乡公共服务一体化

由于城乡和区域发展不平衡所造成的深层次矛盾突出,民族地区在公共服务领域和其他地区还存在明显的差距。加快推进民族地区城乡公共服务一体化进程,其基本途径是统筹城乡发展,在加快转变经济发展方式中促进城乡一体化,以保障和改善民生为重点,以完善的制度安排和政策体系为保障,加大中央财政在教育、医疗卫生、社会保障、公共基础设施等方面对民族地区的扶持力度,创新社会管理,逐步形成覆盖城乡居民的基本公共服务体系。