Hormonal influence on metastatic spread of the Yoshida sarcoma

Zusammenfassung Es wird über die Verbreitung des metastatischen Yoshida-Sarkoms bei Ratten berichtet, die das Sarkom in den Schwanz geimpft erhielten. Die geimpften Tiere wurden mit Testosteron, Cortison und Östrogen behandelt. Die einfache Einpflanzung des Sarkoms ist nicht genügend, um die Verbreitung der Geschwulst zu veranlassen.     

Selection at the Adh locus inDrosophila melanogaster: Adult survivorship-mortality in response to ethanol

Summary Functionally significant biochemical properties of the naturally occurring electrophoretic variants at the Adh locus (ADH^fast and ADH^Slow) are correlated with the adult flies' ability to utilize and survive in an ethanol environment. The results are consistent with the idea that an environmentally dependent form of balancing selection is responsible, at least in part, for the maintenance of the polymorphism at this locus.Acknowledgment. This work was supported by NSF grant DEB 7815466 to J.M.     

Volatility Forecasting via MIDAS,HAR and their Combination: An Empirical Comparative Study for IBOVESPA

In this paper we compare several multi‐period volatility forecasting models, specifically from MIDAS and HAR families. We perform our comparisons in terms of out‐of‐sample volatility forecasting accuracy. We also consider combinations of the models' forecasts. Using intra‐daily returns of the BOVESPA index, we calculate volatility measures such as realized variance, realized power variation and realized bipower variation to be used as regressors in both models. Further, we use a nonparametric procedure for separately measuring the continuous sample path variation and the discontinuous jump part of the quadratic variation process. Thus MIDAS and HAR specifications with the continuous sample path and jump variability measures as separate regressors are estimated. Our results in terms of mean squared error suggest that regressors involving volatility measures which are robust to jumps (i.e. realized bipower variation and realized power variation) are better at forecasting future volatility. However, we find that, in general, the forecasts based on these regressors are not statistically different from those based on realized variance (the benchmark regressor). Moreover, we find that, in general, the relative forecasting performances of the three approaches (i.e. MIDAS, HAR and forecast combinations) are statistically equivalent. Copyright © 2014 John Wiley & Sons, Ltd.     

Phyllostomid bats flying in daylight: a case from the Neotropics

Bats (Chiroptera), one of the most diverse groups in terms of taxonomy, morphology and ecology, are known for their nocturnal behaviour of flight and feeding. Although there is no consensus on the evolution of nocturnality in bats, many authors mention risk of predation, overheating, competition and mobbing by non-competitor species as arguments to justify nocturnal instead of daytime flight in bats. Herein we describe the first records of three genera of phyllostomid bats flying, foraging and drinking water during daytime in the Brazilian Amazon. All taxa were recorded drinking water, and some Phyllostomus sp. individuals were recorded foraging on termites, alongside birds. Risk of dehydration and overheating in roosts, as well as low competition in daytime, may explain the emergence of phyllostomid bats before sunset.     

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ～8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in ～70,000 cases and ～68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 × 10(-35)), 12q24 (rs1292011; P = 4.3 × 10(-19)) and 21q21 (rs2823093; P = 1.1 × 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.     

A common coding variant in CASP8 is associated with breast cancer risk

The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.     

Review of Loxopus Townes (Hymenoptera,Ichneumonidae, Cryptinae), with descriptions of six new species

The taxonomic limits of Loxopus Townes are reviewed. The genus is characterized by the lateral margin of the clypeus projecting as subtriangular lobe; lateral lobes of fourth tarsomeres distinctly longer than mesal lobes; fore wing vein 3r-m absent; hind wing vein 2-1A absent or vestigial; and first metasomal tergite with a basolateral tooth. It occurs from Mexico to southern Brazil. Nine species are recognized, of which six are described as new: L. dodecius Santos et Aguiar, L. duckei Santos et Aguiar, L. exius Santos et Aguiar, L. ichilus Santos et Aguiar, L. tenuis Santos et Aguiar, and L. venezuelanus Santos et Aguiar. The type species, L. australis Townes, and L. multicolor Kasparyan et Ruíz-Cancino are redescribed, and a diagnosis is provided for L. unicolor Kasparyan et Ruíz-Cancino, not examined. All studied species are illustrated and distribution records are mapped. An identification key for the species of Loxopus is presented.

http://zoobank.org/urn:lsid:zoobank.org:pub:5B73E8B4-1288-4FD9-AABD-845B5085FFE3