油藏数值模拟在剩余油预测中的不确定性分析

油藏数值模拟作为一种定量的剩余油饱和度预测方法 ,在油田开发后期剩余油分布研究中起着越来越重要的作用 ,但其预测精度也不可避免地受到多种因素的影响。对剩余油预测中油藏数值模拟精度的影响因素进行了分析 ,结果表明 ,地层对比的多解性、储层物性参数求取的不确定性以及储层非均质描述的局限性是影响数值模拟精度的主要地质因素。此外 ,相对渗透率曲线的选取、动态数据的获取及数值模拟软件本身都存在较大的不确定性 ,这些都会影响到油藏数值模拟的精度。因此 ,在剩余油研究过程中 ,不能过分依赖油藏数值模拟。应该综合运用地质、地震、测井、油藏工程、油藏数值模拟等多学科知识进行研究 ,以提高剩余油饱和度的预测精度。     

基于图像信息处理的车辆自动驾驶控制方法

在分析驾驶员利用图像信息进行驾驶的一般规律基础上,提出了利用图像信息处理技术实现车辆路迹追踪自动行驶的控制方法和规则,并进行了模拟计算和试验．结果表明,所提出的控制方法和规则用于进行车辆的自动驾驶是可行的．     

用具有零权的平差方法求解秩亏自由网的研究

以秩亏自由网平差的法方程系数阵的特征根作为虚拟权 ,构造两组虚拟误差方程 ,其中一组具有零权 ,从而用具有零权的平差思想 ,导出求解秩亏自由网待估参数平差值及其协因数的公式 ,并指出 ,此结果与用主成分估计法求解秩亏自由网的结果完全一致。     

OsNAC2转录因子介导生长素代谢通路调节水稻早期根的发育

NAC家族是植物特有的一类转录因子,在植物的生长发育和逆境胁迫等方面具有重要的功能.研究发现,OsNAC2基因的过表达(ON11)和RNAi(RNAi31)转基因株系,早期主根的长度有显著变化的特征.与野生型日本晴水稻(WT)相比,ON11植株的主根变短,而RNAi31的主根变长.通过对早期OsNAC2pro∶∶GUS株系根尖染色结果表明OsNAC2在根尖具有时序性表达.不同激素诱导OsNAC2表达谱和OsNAC2pro∶∶GUS株系对激素响应结果显示OsNAC2受生长素显著性诱导.结合芯片数据和qRT-PCR分析,OsNAC2转基因株系中生长素合成代谢及信号通路相关基因表达量变化较为明显.同时,ON11根尖淀粉粒发育及其向重力性受到抑制.因此,推测OsNAC2可能通过抑制生长素的合成代谢及信号通路相关基因的表达,降低生长素含量,并参与生长素响应通路,最终影响水稻根的生长.     

二维圆柱层流绕流及其控制数值模拟

采用有限体积法求解二维N-S方程,通过改变时间、空间计算参数,对雷诺数100的二维圆柱非定常流场进行了数值模拟,将所得结果与实验数据以及已有的计算结果进行了对比.并对在尾部多个位置加入不同长度阻隔板控制流动的圆柱流场进行了考察.结果发现:在合适的位置放置阻隔板,可以有效抑制尾迹中涡脱落的形成.     

基于遗传算法的模糊聚类方法

针对模糊c 均值算法容易收敛于局部极小点的缺陷 ,将遗传算法应用于模糊c 均值算法的优化计算中 .算法采用实数编码 ,提高了试验精度 .实验证明基于遗传算法的模糊聚类方法能够在一定程度上克服初值的影响 ,跳出局部极小点 ,在大样本的聚类方面有较大的优势 .     

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

A locus segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21, close to the amyloid precursor protein (APP) gene. Recombinants between the APP gene and the AD locus have been reported which seemed to exclude it as the site of the mutation causing familial AD. But recent genetic analysis of a large number of AD families has demonstrated that the disease is heterogeneous. Families with late-onset AD do not show linkage to chromosome 21 markers. Some families with early-onset AD show linkage to chromosome 21 markers, but some do not. This has led to the suggestion that there is non-allelic genetic heterogeneity even within early onset familial AD. To avoid the problems that heterogeneity poses for genetic analysis, we have examined the cosegregation of AD and markers along the long arm of chromosome 21 in a single family with AD confirmed by autopsy. Here we demonstrate that in this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene. This mutation causes an amino-acid substitution (Val----Ile) close to the carboxy terminus of the beta-amyloid peptide. Screening other cases of familial AD revealed a second unrelated family in which this variant occurs. This suggests that some cases of AD could be caused by mutations in the APP gene.     

Observation of rare-earth segregation in silicon nitride ceramics at subnanometre dimensions

Silicon nitride (Si3N4) ceramics are used in numerous applications because of their superior mechanical properties. Their intrinsically brittle nature is a critical issue, but can be overcome by introducing whisker-like microstructural features. However, the formation of such anisotropic grains is very sensitive to the type of cations used as the sintering additives. Understanding the origin of dopant effects, central to the design of high-performance Si3N4 ceramics, has been sought for many years. Here we show direct images of dopant atoms (La) within the nanometre-scale intergranular amorphous films typically found at grain boundaries, using aberration corrected Z-contrast scanning transmission electron microscopy. It is clearly shown that the La atoms preferentially segregate to the amorphous/crystal interfaces. First-principles calculations confirm the strong preference of La for the crystalline surfaces, which is essential for forming elongated grains and a toughened microstructure. Whereas principles of micrometre-scale structural design are currently used to improve the mechanical properties of ceramics, this work represents a step towards the atomic-level structural engineering required for the next generation of ceramics.     

中国碳纳米管领域研发能力评估

碳纳米管是国际材料科学的前沿领域之一,研究成果不断涌现,这些研究成果主要以研究论文和专利的形式出现。随着近年来中国科研实力的提升,中国科学家在碳纳米管研究领域也取得了相当突出的成绩,影响力越来越大。利用Web of Science和Derwent Aureka对2000—2009年碳纳米管相关的论文及专利进行检索分析,对我国碳纳米管领域的研发能力进行了评估。     

Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients

N-cadherin is related to the progression and metastases of several solid carcinomas. However, it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency. In this study, we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120 patients with colorectal cancer. We revealed that N-cadherin was expressed in 78.3% (94/120) of colorectal tumor tissues and in only 9.2% (11/120) of paired distant normal mucosa tissues with a significant difference (P=0.000). The low, moderate, and high expression of N-cadherin protein was 42.5%, 30.8%, and 26.7%, respectively. N-cadherin overexpression was associated with advanced TNM stage, lymph nodes metastasis and distant metastasis (P<0.05). Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression, and patients with low expression had a better survival rate than those with moderate and high expression (P<0.05). In conclusion, high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer, and may prove to be a possible prognostic factor.