可交易通行权和鼓励合乘政策下的通勤选择

基于通勤个体易于接受的视角,借助常数替代弹性(constant elasticity of substitution,CES)效用函数,在通勤预算约束中引入管理部门对拼车通勤行为的支持系数,构建了基于可交易电子通行权及鼓励合乘组合政策的刚性通勤需求模型,在此基础上分析了通勤个体的通勤方式选择问题.研究结果显示,该组合政策可以有效引导通勤个体从单人驾驶转向合乘出行,通勤个体能够在降低原有出行预算的基础上保证自身的刚性出行需求,但对小汽车偏好较大的通勤个体预算降低幅度相对较小.此外,存在一个调整因子和合乘支持系数的取值可行域,对于不同的合乘支持系数,调整因子存在一个对应的下界.在设定调整因子和合乘支持系数后,通行权价格由市场唯一确定,且这一价格随着合乘支持系数的增加而增加,调整因子的增加而降低.     

一类伪不变凸极值问题解集的刻画

有研究对可微的无约束伪不变凸极值问题的解集进行了刻画。本文在此基础上,在广义不变凸性假设下,利用广义Clarke梯度和Lagrange乘子研究了一类不可微的带约束的伪不变凸极值问题的一些性质。首先在广义Clarke梯度的基础上,给出了此类带约束的非可微伪不变凸极值问题的一些性质;然后在一定条件下证明了此类问题的可行集和最优解集是不变凸的;最后利用广义Clarke梯度和Lagrange乘子得到了最优解集的一些等价刻画。
     

模糊随机过程的Itô-Henstock积分

定义和讨论了适应的模糊随机过程关于Brownian运动的模糊Itô-Henstock积分和模糊Itô-McShane积分及其性质,给出了刻画定理,并讨论了两者之间的相互关系。结果表明,当模糊Itô-Henstock积分原函数Itô 绝对连续时,模糊Itô-Henstock积分和模糊Itô-McShane积分等价。     

涠洲岛两种石珊瑚在高温胁迫下共生细菌群落结构变化特征

石珊瑚中的块状珊瑚与枝状珊瑚对全球气候变暖胁迫的耐受能力明显不同,但其机制仍不清楚。本研究选择北部湾涠洲岛的一种属于块状珊瑚的海孔角蜂巢珊瑚(Favites halicora)和一种属于枝状珊瑚的浪花鹿角珊瑚(Acropora cytherea)为研究对象,通过室内模拟实验,分析高温胁迫下(26～34℃) 2种珊瑚共生细菌群落的响应特征。结果表明:共生细菌多样性具有差异性,A.cytherea共生细菌的多样性随着温度上升变化显著,Shannon指数由2.20变为4.05,而F.halicora变化幅度较小,在2.69～3.19波动;主导细菌存在差异,在门水平上,F.halicora占主导地位的共生细菌为Proteobacteria (29%～73%)、Cyanobacteria (7%～63%)和Bacteroidetes(3%～13%),而A. cytherea为Proteobacteria (49%～90%)、Cyanobacteria (1%～16%)、Bacteroidetes (3%～16%)、Firmicutes (1%～6%)和一个未分类的细菌门unclassified_k_norank(0.6%～21.0%);升温胁迫时,主导细菌的丰度变化存在差别,Bacteroidetes在F.halicora中显著降低,而在A.cytherea中显著升高,unclassified_k_norank在A.cytherea中也显著升高;随着温度升高,2种珊瑚共生细菌的变化趋势一致,但珊瑚中出现潜在致病菌Vibrio的温度不同,F.halicora在34℃胁迫时出现,A.cytherea在30℃和34℃胁迫时均出现。根据上述结果推测,珊瑚共生细菌的差异性可能是导致块状珊瑚比枝状珊瑚更耐受高温的重要原因。     

Flow and heat transfer behaviour of nanofluids in microchannels

Flow and heat transfer of aqueous based silica and alumina nanofluids in microchannels were experimentally investigated. The measured friction factors were higher than conventional model predictions at low Reynolds numbers particularly with high nanoparticle concentrations. A decrease in the friction factor was observed with increasing Reynolds number, possibly due to the augmentation of nanoparticle aggregate shape arising from fluid shear and alteration of local nanoparticle concentration and nanofluid viscosity. Augmentation of the silica nanoparticle morphology by fluid shear may also have affected the friction factor due to possible formation of a core/shell structure of the particles. Measured thermal conductivities of the silica nanofluids were in approximate agreement with the Maxwell-Crosser model, whereas the alumina nanofluids only showed slight enhancements. Enhanced convective heat transfer was observed for both nanofluids, relative to their base fluids (water), at low particle concentrations. Heat transfer enhancement increased with increasing Reynolds number and microchannel hydraulic diameter. However, the majority of experiments showed a larger increase in pumping power requirements relative to heat transfer enhancements, which may hinder the industrial uptake of the nanofluids, particularly in confined environments, such as Micro Electro-Mechanical Systems (MEMS).     

改进的支持向量机低分辨雷达目标分类算法

针对雷达目标识别系统中存在库外目标、各特征属性分类性能不一致,低分辨雷达不同类别目标特征值分布区间混叠的问题。文中基于支持向量机分类算法,对目标样本特征值进行置信度分析,获得置信区间,利用代价函数确定拒识门限,对库外目标以及混叠区域目标进行拒识分析;并根据训练样本先验识别率使用注水原理分配特征属性权重;在此基础上利用支持向量机进行目标识别。雷达实测数据实验结果表明,引入置信拒识分析与注水分配加权后,分类器性能得到了有效改善。     

纤维增强悬臂复合薄板固有特性分析与验证

采用理论与实际相结合的方式,对悬臂状态下纤维增强复合薄板的固有特性进行了分析与验证.首先,基于双向梁函数法,推导了具任意纤维角度下该类型复合薄板的最大动能和应变能,明确了利用该方法获取固有频率和模态振型的原理.然后,编写了Matlab计算程序,并给出了分析纤维增强悬臂薄板固有特性的具体流程.最后,搭建了固有特性测试系统,并以TC500碳纤维/树脂复合薄板为研究对象,进行了实际测试.验证结果表明,基于双向梁函数法的纤维增强复合薄板固有频率计算结果与实验结果的误差在3.7%~9.7%,且前5阶振型结果也与测试振型结果一致,进而验证了所提出的理论分析方法的正确性.     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.     

本科教学中逻辑性课程《纳米材料》的主线设计探索

《纳米材料》课程主要讲解纳米材料的结构与性能之间关系的概念与理论,这种定位决定了纳米材料课应采用逻辑教学法.在这种方法下需找到课程逻辑起点,然后沿着起点设计出一条课程主线,建立课程理论体系,从而合理承接培养方案中的课程群.在《纳米材料》中,纳米结构就是逻辑起点,主线就是"结构与性能"的关系.故该门课程应按"结构和性能"这条主线展开.对现行纳米材料课程内容进行分析,大部分内容均可用主线串联起来.该方法为类似的逻辑性课程教学方法改革以及在课程章节内容之间建立逻辑关联提供借鉴.     

非线性光机械系统中的弱力探测

从理论上研究了包含光学参量放大器的非线性腔光机械系统的弱力探测性能.一方面,发现通过调节光学参量放大器的非线性增益以及输入光场与腔场之间的有效失谐,可以减小压缩正交中约14 dB的量子噪声,从而将弱力探测灵敏度提高2倍以上.另一方面,分析了非线性腔结合零差测量产生的反作用噪声相消现象并且实现量子非破坏测量的方法.