全文获取类型
收费全文 | 25084篇 |
免费 | 79篇 |
国内免费 | 115篇 |
专业分类
系统科学 | 118篇 |
丛书文集 | 168篇 |
教育与普及 | 70篇 |
理论与方法论 | 65篇 |
现状及发展 | 10523篇 |
研究方法 | 1157篇 |
综合类 | 12822篇 |
自然研究 | 355篇 |
出版年
2013年 | 165篇 |
2012年 | 364篇 |
2011年 | 714篇 |
2009年 | 158篇 |
2008年 | 458篇 |
2007年 | 539篇 |
2006年 | 514篇 |
2005年 | 529篇 |
2004年 | 485篇 |
2003年 | 492篇 |
2002年 | 462篇 |
2001年 | 934篇 |
2000年 | 923篇 |
1999年 | 594篇 |
1994年 | 338篇 |
1992年 | 555篇 |
1991年 | 424篇 |
1990年 | 484篇 |
1989年 | 430篇 |
1988年 | 392篇 |
1987年 | 442篇 |
1986年 | 457篇 |
1985年 | 587篇 |
1984年 | 427篇 |
1983年 | 383篇 |
1982年 | 345篇 |
1981年 | 332篇 |
1980年 | 332篇 |
1979年 | 842篇 |
1978年 | 631篇 |
1977年 | 580篇 |
1976年 | 499篇 |
1975年 | 514篇 |
1974年 | 601篇 |
1973年 | 531篇 |
1972年 | 530篇 |
1971年 | 620篇 |
1970年 | 831篇 |
1969年 | 623篇 |
1968年 | 628篇 |
1967年 | 574篇 |
1966年 | 573篇 |
1965年 | 410篇 |
1959年 | 212篇 |
1958年 | 348篇 |
1957年 | 225篇 |
1956年 | 207篇 |
1955年 | 178篇 |
1954年 | 194篇 |
1948年 | 169篇 |
排序方式: 共有10000条查询结果,搜索用时 359 毫秒
301.
T. Covarrubias-Camarillo M. Osorio-Beristain L. Legal 《Journal of Natural History》2016,50(35-36):2299-2310
In at least 18 Lepidoptera families, caterpillars build shelters that mainly serve to regulate microclimate (humidity, temperature) and/or to avoid predation. We aimed to explore the function of the tubular structures built with the leaves of the host plant, Acacia cochliacantha Humboldt and Bonpland ex Willdenow (Fabaceae), by a lepidopteran endemic to Mexico, Baronia brevicornis Salvin. We experimentally evaluated whether tubular structure building behaviour is induced by high temperature or predator odour, and if shelters reduce or enhance predation of B. brevicornis caterpillars. We used Calosoma angulatum as predator. Our analyses showed that caterpillars did not make the tubular structures in response to high temperature. We also found no difference in predators’ visual recognition of sheltered versus unsheltered caterpillars. Caterpillars did not build shelters but they moved more often when exposed to predator odour. Unsheltered caterpillars were more frequently consumed when predators were allowed to interact with sheltered and unsheltered caterpillars. Hence, the tubular structures built by B. brevicornis are most likely a strategy for reducing predation, for example by C. angulatum. 相似文献
302.
303.
Vincent A. van der Mark Mohammed Ghiboub Casper Marsman Jing Zhao Remco van Dijk Johan K. Hiralall Kam S. Ho-Mok Zoë Castricum Wouter J. de Jonge Ronald P. J. Oude Elferink Coen C. Paulusma 《Cellular and molecular life sciences : CMLS》2017,74(4):715-730
P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen the inflammatory response and to mediate the endotoxin-induced endocytic retrieval of Toll-like receptor 4 (TLR4) in human macrophages. Depletion of CDC50A, the β-subunit that is crucial for the activity of multiple P4-ATPases, resulted in endotoxin-induced hypersecretion of proinflammatory cytokines, enhanced MAP kinase signaling and constitutive NF-κB activation. In addition, CDC50A-depleted THP-1 macrophages displayed reduced tolerance to endotoxin. Moreover, endotoxin-induced internalization of TLR4 was strongly reduced and coincided with impaired endosomal MyD88-independent signaling. The phenotype of CDC50A-depleted cells was also induced by separate knockdown of two P4-ATPases, namely ATP8B1 and ATP11A. We conclude that lipid flippases are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4. 相似文献
304.
305.
Jeannette S. Messer 《Cellular and molecular life sciences : CMLS》2017,74(7):1281-1296
Cell death is a major determinant of inflammatory disease severity. Whether cells live or die during inflammation largely depends on the relative success of the pro-survival process of autophagy versus the pro-death process of apoptosis. These processes interact and influence each other during inflammation and there is a checkpoint at which cells irrevocably commit to either one pathway or another. This review will discuss the concept of the autophagy/apoptosis checkpoint and its importance during inflammation, the mechanisms of inflammation leading up to the checkpoint, and how the checkpoint is regulated. Understanding these concepts is important since manipulation of the autophagy/apoptosis checkpoint represents a novel opportunity for treatment of inflammatory diseases caused by too much or too little cell death. 相似文献
306.
Andrey V. Kulikov Alexander S. Vdovin Boris Zhivotovsky Vladimir Gogvadze 《Cellular and molecular life sciences : CMLS》2014,71(12):2325-2333
Rapidly proliferating tumor cells easily become hypoxic. This results in acquired stability towards treatment with anticancer drugs. Here, we show that cells grown at 0.1 % oxygen are more resistant towards treatment with the conventionally used anticancer drugs doxorubicin and cisplatin. The stimulation of apoptosis, as assessed by the number of cells in the SubG1 fraction of the cell cycle, release of cytochrome c into the cytosol, activation of caspase-3, and cleavage of PARP, was markedly suppressed under low oxygen content or when hypoxia was mimicked by deferoxamine. Hypoxia or deferoxamine treatment was accompanied by stabilization of the hypoxia-inducible factor (HIF-1). The downregulation of HIF-1 using siRNA technique restored cell sensitivity to treatment under hypoxic conditions to the levels detected under normoxic conditions. In contrast to cisplatin or doxorubicin, α-tocopheryl succinate (α-TOS), a compound that targets mitochondria, stimulated cell death irrespective of the oxygen concentration. Moreover, under hypoxic condition cell death induced by α-TOS was even enhanced. Thus, α-TOS can successfully overcome resistance to treatment caused by hypoxia, which makes α-TOS an attractive candidate for antitumor therapy via mitochondrial targeting. 相似文献
307.
Vincent T. Marchesi 《Cellular and molecular life sciences : CMLS》2014,71(6):949-955
This essay explores an alternative pathway to Alzheimer’s dementia that focuses on damage to small blood vessels rather than late-stage toxic amyloid deposits as the primary pathogenic mechanism that leads to irreversible dementia. While the end-stage pathology of AD is well known, the pathogenic processes that lead to disease are often assumed to be due to toxic amyloid peptides that act on neurons, leading to neuronal dysfunction and eventually neuronal cell death. Speculations as to what initiates the pathogenic cascade have included toxic abeta peptide aggregates, oxidative damage, and inflammation, but none explain why neurons die. Recent high-resolution NMR studies of living patients show that lesions in white matter regions of the brain precede the appearance of amyloid deposits and are correlated with damaged small blood vessels. To appreciate the pathogenic potential of damaged small blood vessels in the brain, it is useful to consider the clinical course and the pathogenesis of CADASIL, a heritable arteriopathy that leads to damaged small blood vessels and irreversible dementia. CADASIL is strikingly similar to early onset AD in that it is caused by germ line mutations in NOTCH 3 that generate toxic protein aggregates similar to those attributed to mutant forms of the amyloid precursor protein and presenilin genes. Since NOTCH 3 mutants clearly damage small blood vessels of white matter regions of the brain that lead to dementia, we speculate that both forms of dementia may have a similar pathogenesis, which is to cause ischemic damage by blocking blood flow or by impeding the removal of toxic protein aggregates by retrograde vascular clearance mechanisms. 相似文献
308.
Carol D. Curtis Reema B. Davis Kyle G. Ingram Courtney T. Griffin 《Cellular and molecular life sciences : CMLS》2012,69(23):3921-3931
Vascular development is a dynamic process that relies on the coordinated expression of numerous genes, but the factors that regulate gene expression during blood vessel development are not well defined. ATP-dependent chromatin-remodeling complexes are gaining attention for their specific temporal and spatial effects on gene expression during vascular development. Genetic mutations in chromatin-remodeling complex subunits are revealing roles for the complexes in vascular signaling pathways at discrete developmental time points. Phenotypic analysis of these models at various stages of vascular development will continue to expand our understanding of how chromatin remodeling impacts new blood vessel growth. Such research could also provide novel therapeutic targets for the treatment of vascular pathologies. 相似文献
309.
310.
T Reichhardt 《Nature》2001,411(6841):979-980