A cat cloned by nuclear transplantation

Sheep, mice, cattle, goats and pigs have all been cloned by transfer of a donor cell nucleus into an enucleated ovum, and now we add the successful cloning of a cat (Felis domesticus) to this list. However, this cloning technology may not be readily extendable to other mammalian species if our understanding of their reproductive processes is limited or if there are species-specific obstacles.     

Petrological implication of wagnerite-Ma5bc in the quartzofeldspathic gneiss, Larsemann Hills, East Antarctica

Mg dominantmineralsofwagnerite triplite group,i.e.(Mg,Fe,Mn)2(PO4)(F,OH),arerelativelyrare,buthavebeenfoundinawidevariety ofgeologicenvironments,includingmetamorphic rocksofallgrades[1]suchasquartz carbonateveinsof hydrothermalorigin,pegmatites,kyanite quartzite,micaschist,sillimanitegneiss,andmagnetiteores.Uptonow,wagneriteispresentmainlyasthe Ma2bcpolytype,anaccessorymineralincalcium poorrocks[2,5]inwhichapatite,ifpresent,oftenoc cursasretrograderimaroundwagnerite.Henriques[6]reportedasma…     

旅游民族志

通过旅游民族志研究对当代旅游人类学所面临的一些问题进行探讨,亦即不仅在旅游人类学范围内考察有关民族志问题,而且将这些问题置于人类学的当代实践之中,包括:长期和短期的民族志研究、民族志田野作业的传统、民族志的时空策略、旅游民族志中的特殊问题等。     

Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.

Pigmentary glaucoma is a significant cause of human blindness. Abnormally liberated iris pigment and cell debris enter the ocular drainage structures, leading to increased intraocular pressure (IOP) and glaucoma. DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment dispersion (IPD) and iris stromal atrophy (ISA). Using high-resolution mapping techniques, sequencing and functional genetic tests, we show that IPD and ISA result from mutations in related genes encoding melanosomal proteins. IPD is caused by a premature stop codon mutation in the Gpnmb (GpnmbR150X) gene, as proved by the occurrence of IPD only in D2 mice that are homozygous with respect to GpnmbR150X; otherwise, similar D2 mice that are not homozygous for GpnmbR150X do not develop IPD. ISA is caused by the recessive Tyrp1b mutant allele and rescued by the transgenic introduction of wildtype Tyrp1. We hypothesize that IPD and ISA alter melanosomes, allowing toxic intermediates of pigment production to leak from melanosomes, causing iris disease and subsequent pigmentary glaucoma. This is supported by the rescue of IPD and ISA in D2 eyes with substantially decreased pigment production. These data indicate that pigment production and mutant melanosomal protein genes may contribute to human pigmentary glaucoma. The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma.     

超新星背后的秘密

在宇宙的某个地方每一秒钟都会发生超新星爆发。即使它们的距离极为遥远,这一恒星灾变现象仍能为我们提供有关恒星形成的重要信息——其抛射出几个太阳质量的恒星碎片丰富了星际空间重元素和放射性元素的含量。 尽管超新星非常的明亮,但是超新星爆发的能量     

早-中元古代Columbia超级大陆研究进展

地球在过去25亿年里曾发生过几次全球性大规模碰撞造山事件（如 Grenville事件,Pan-African事件等）;地质学家由此推测大陆块自早元古代以来曾发生过周期性拼合和分离,从而导致古超级大陆的形成和裂解[1].在过去10年里（1991～2001年）,被认为由约1.0 Ga Grenville造山事件所形成的超级大陆Rodinia已成为古大陆重建的一个热点[2,3].然而,地质学家们在重建Rodinia 过程中发现,并非全部Rodinia组成陆块都是由Grenville造山带所焊接,而