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41.
Ruth A. Bernstein 《Cellular and molecular life sciences : CMLS》1978,34(10):1281-1282
Summary Evidence of slave-making habits in 2 species of the subfamily Dolichoderinae has been found in arid habitats of western North America. The enslaved species are of the subfamilies Myrmicinae and Formicinae. In previously reported cases of slavery in ants, both the slave-making and enslaved species are of the subfamily Formicinae., In the 2 new cases of slavery reported here, presence of slaves of another species in a colony significantly increases the breadth of diet and/or the range of temperatures at which the colony forages. 相似文献
42.
Wernig M Meissner A Foreman R Brambrink T Ku M Hochedlinger K Bernstein BE Jaenisch R 《Nature》2007,448(7151):318-324
43.
Ruth E. Kastner 《Foundations of Science》2013,18(1):1-9
It is hypothesized that de Broglie’s ‘matter waves’ provide a dynamical basis for Minkowski spacetime in an antisubstantivalist or relational account. The relativity of simultaneity is seen as an effect of the de Broglie oscillation together with a basic relativity postulate, while the dispersion relation from finite rest mass gives rise to the differentiation of spatial and temporal axes. Thus spacetime is seen as not fundamental, but rather as emergent from the quantum level. A result by Solov’ev which demonstrates that time is not an applicable concept at the quantum level is adduced in support of this claim. Finally, it is noted that de Broglie waves can be seen as the “bridge of becoming” discussed by (2005). 相似文献
44.
45.
E S Vitetta J W Uhr J Klein F Pazderka E J Moticka R F Ruth J D Capra 《Nature》1977,270(5637):535-536
46.
Primary structure and functional expression from complementary DNA of a brain calcium channel. 总被引:43,自引:0,他引:43
Y Mori T Friedrich M S Kim A Mikami J Nakai P Ruth E Bosse F Hofmann V Flockerzi T Furuichi 《Nature》1991,350(6317):398-402
The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells. 相似文献
47.
48.
Wen L Ley RE Volchkov PY Stranges PB Avanesyan L Stonebraker AC Hu C Wong FS Szot GL Bluestone JA Gordon JI Chervonsky AV 《Nature》2008,455(7216):1109-1113
Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influence disease pathogenesis. The incidence of spontaneous T1D in non-obese diabetic (NOD) mice can be affected by the microbial environment in the animal housing facility or by exposure to microbial stimuli, such as injection with mycobacteria or various microbial products. Here we show that specific pathogen-free NOD mice lacking MyD88 protein (an adaptor for multiple innate immune receptors that recognize microbial stimuli) do not develop T1D. The effect is dependent on commensal microbes because germ-free MyD88-negative NOD mice develop robust diabetes, whereas colonization of these germ-free MyD88-negative NOD mice with a defined microbial consortium (representing bacterial phyla normally present in human gut) attenuates T1D. We also find that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD88-negative NOD donors attenuates T1D in germ-free NOD recipients. Together, these findings indicate that interaction of the intestinal microbes with the innate immune system is a critical epigenetic factor modifying T1D predisposition. 相似文献
49.
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration 总被引:3,自引:0,他引:3
In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life, and are an important model for organ regeneration. Hair stem cells located in the follicle bulge are regulated by the surrounding microenvironment, or niche. The activation of such stem cells is cyclic, involving periodic beta-catenin activity. In the adult mouse, regeneration occurs in waves in a follicle population, implying coordination among adjacent follicles and the extrafollicular environment. Here we show that unexpected periodic expression of bone morphogenetic protein 2 (Bmp2) and Bmp4 in the dermis regulates this process. This BMP cycle is out of phase with the WNT/beta-catenin cycle, thus dividing the conventional telogen into new functional phases: one refractory and the other competent for hair regeneration, characterized by high and low BMP signalling, respectively. Overexpression of noggin, a BMP antagonist, in mouse skin resulted in a markedly shortened refractory phase and faster propagation of the regenerative wave. Transplantation of skin from this mutant onto a wild-type host showed that follicles in donor and host can affect their cycling behaviours mutually, with the outcome depending on the equilibrium of BMP activity in the dermis. Administration of BMP4 protein caused the competent region to become refractory. These results show that BMPs may be the long-sought 'chalone' inhibitors of hair growth postulated by classical experiments. Taken together, results presented in this study provide an example of hierarchical regulation of local organ stem cell homeostasis by the inter-organ macroenvironment. The expression of Bmp2 in subcutaneous adipocytes indicates physiological integration between these two thermo-regulatory organs. Our findings have practical importance for studies using mouse skin as a model for carcinogenesis, intra-cutaneous drug delivery and stem cell engineering studies, because they highlight the acute need to differentiate supportive versus inhibitory regions in the host skin. 相似文献
50.
Lambert F Delmonte B Petit JR Bigler M Kaufmann PR Hutterli MA Stocker TF Ruth U Steffensen JP Maggi V 《Nature》2008,452(7187):616-619
Dust can affect the radiative balance of the atmosphere by absorbing or reflecting incoming solar radiation; it can also be a source of micronutrients, such as iron, to the ocean. It has been suggested that production, transport and deposition of dust is influenced by climatic changes on glacial-interglacial timescales. Here we present a high-resolution record of aeolian dust from the EPICA Dome C ice core in East Antarctica, which provides an undisturbed climate sequence over the past eight climatic cycles. We find that there is a significant correlation between dust flux and temperature records during glacial periods that is absent during interglacial periods. Our data suggest that dust flux is increasingly correlated with Antarctic temperature as the climate becomes colder. We interpret this as progressive coupling of the climates of Antarctic and lower latitudes. Limited changes in glacial-interglacial atmospheric transport time suggest that the sources and lifetime of dust are the main factors controlling the high glacial dust input. We propose that the observed approximately 25-fold increase in glacial dust flux over all eight glacial periods can be attributed to a strengthening of South American dust sources, together with a longer lifetime for atmospheric dust particles in the upper troposphere resulting from a reduced hydrological cycle during the ice ages. 相似文献