Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

本科生导师制下地理信息科学专业实践教学模式的研究

基于地理信息科学专业实践教学的特点,阐述了重庆师范大学本科生导师制下地理信息科学专业的实践教学模式及其现状,并从专业课程教学,科研项目,导师制评价和管理制度,面向专业竞赛的实践教学,本科研学团队和专业实习基地等方面论述了教改效果及改进措施.通过改革,地理信息科学专业学生的培养质量和竞争力得到了较大提升,符合我国地理信息产业长远和健康发展的需要.     

不同理性预期下Stackelberg模型的动态复杂性

构建双寡头参与人分别采取有限理性和天真理性预期的Stackelberg博弈模型,研究市场均衡的稳定性条件及动态复杂性特征.通过理论求解和数值模拟得出结论:参与人在不完全信息和不同理性情况下,Stackelberg模型的参数取值范围决定了动态系统的稳定性、产量分岔、利润分岔、奇怪吸引子、吸引子维数和混沌等;如果参数取值满足一定条件,静态Stackelberg推测变差均衡能够实现;否则,Stackelberg推测变差均衡不稳定,非线性动态经济系统可能会出现周期变化或混沌的现象.     

Supply chain performance for deteriorating items with cooperative advertising

To study the effect of cooperative advertising on the supply chain of deteriorating items, this paper establishes a Stackelberg game model for a two-echelon deteriorating items supply chain composed of one manufacturer and one retailer under a given support program with an exogenous participation rate. The manufacturer as the leader determines the wholesale price and production rate, and the retailer as the follower determines the retail price and advertising strategies. The strategies of the players under the decentralized scenario and the centralized scenario are respectively characterized. Numerical simulations and sensitivity analysis are conducted to gain some managerial insights. It is shown that the pricing, advertising and production strategies are negatively correlated to deteriorating coefficient, and both the profit and the channel efficiency decrease with deteriorating coefficient; The interaction between price, advertising investment and production rate results in a higher retail price of the centralized channel compared to that of the decentralized channel; Implementing the cooperative advertising program does improve the performance of the supply chain in some cases and the participation rate roughly at 0.5 is most preferable, but it is also possible to distort incentive and damage the channel performance when the participation rate reaches a relatively high level.     

囚徒困境中基于非均匀连接的促合作控制设计

本文研究"囚徒困境"中促进合作演化的机制,设计"合作识别"和"背叛识别"两种控制形式,并分析合作在相应控制之下的演化路径问题.在合作识别控制设计中,通过将博弈群体分为合作者子群体和合作者与背叛者共存子群体,形成连接率依赖于个体策略的"非均匀连接",以保护合作的方式抑制背叛,促进合作演化;在背叛识别控制设计中,以惩罚背叛的方式鼓励合作.文章指出,合作识别控制设计能在合作率较低时促进合作,但不能使合作成为演化稳定策略(ESS);背叛识别控制设计能在合作率较高时使合作成为ESS,但是背叛总是该控制下的ESS.结合"合作识别"控制与"背叛识别"控制,本文设计一种切换控制,使得合作是"囚徒困境"博弈的唯一ESS.仿真给出不同要求下的控制律设计,分析不同切换选择对合作演化路径的影响.     

Hormonal control of Sertoli cell metabolism regulates spermatogenesis

Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that reach far beyond the physical support of germ cells, as they are responsible for creating the adequate ionic and metabolic environment for germ cell development. Thus, much attention has been given to the metabolic functioning of SCs. During spermatogenesis, germ cells are provided with suitable metabolic substrates, in a set of events mediated by SCs. Multiple signaling cascades regulate SC function and several of these signaling pathways are hormone-dependent and cell-specific. Within the seminiferous tubules, only SCs possess receptors for some hormones rendering them major targets for the hormonal signaling that regulates spermatogenesis. Although the mechanisms by which SCs fulfill their own and germ cells metabolic needs are mostly studied in vitro, SC metabolism is unquestionably a regulation point for germ cell development and the hormonal control of these processes is required for a normal spermatogenesis.     

基于累积延误损失算法的GHP模型

考虑不同机型的不同延误损失费用提出了一种累积延误损失算法,并建立基于该算法的地面等待策略(GHP)数学模型.该算法进行到达航班排序时,以所有航班总延误损失费用为首要排序标准,以先来先服务为第二排序标准,从而得到总延误损失费用与总延误时间值都较小的到达航班序列.同时,该算法也考虑了有后继任务的航班对到达航班序列的影响.基于该算法的GHP模型结合实际数据在实验仿真中取得了较好的效果,表明了该算法与模型的实用性与有效性.     

深基坑支护方案优选的组合赋权灰色关联分析

为了能够更好地对深基坑支护方案进行评价优选,基于层次分析(指数标度)法、欧氏距离法及灰色关联理论,计算了深基坑不同支护方案的加权关联度,提出了深基坑支护方案优选的组合赋权灰色关联分析法,并结合工程实例进行了应用分析.结果表明:运用组合赋权灰色关联分析法避免了单一方法赋权的片面性,可综合考虑主、客观因素的影响,选择出可行的最优方案,对深基坑支护方案优选具有一定的参考意义.     

电子政务中的信息共享平台

信息共享是提高电子政务系统应用效能的关键,也是目前电子政务应用推广应用瓶颈和难题。本文从有关信息共享的一般方法和工程实践出发,论述电子政务中信息共享平台的设计问题,分析信息共享平台组成方式和应用方式。     

软件模式的定义和分类研究

软件模式的本质属性是反映软件开发过程中思维方式和表现,这是软件模式定义的内涵;语境、问题、解决方案和效果等是软件模式的外延．从定义的普遍意义八手,分析软件模式的内涵和外延,对软件模式的定义作初步的研究．同时。对于软件模式的分类问题做进一步的探讨．科学地定义软件模式和对软件模式进行分类,是不断发展和完善软件模式体系的重要问题．