全文获取类型
收费全文 | 408篇 |
免费 | 1篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 6篇 |
丛书文集 | 1篇 |
教育与普及 | 1篇 |
理论与方法论 | 8篇 |
现状及发展 | 66篇 |
研究方法 | 60篇 |
综合类 | 239篇 |
自然研究 | 29篇 |
出版年
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2016年 | 2篇 |
2015年 | 6篇 |
2014年 | 3篇 |
2013年 | 7篇 |
2012年 | 37篇 |
2011年 | 69篇 |
2010年 | 6篇 |
2009年 | 5篇 |
2008年 | 24篇 |
2007年 | 32篇 |
2006年 | 34篇 |
2005年 | 33篇 |
2004年 | 30篇 |
2003年 | 19篇 |
2002年 | 22篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1982年 | 1篇 |
1979年 | 4篇 |
1977年 | 2篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1969年 | 1篇 |
1966年 | 5篇 |
1965年 | 5篇 |
1961年 | 1篇 |
1956年 | 1篇 |
1945年 | 1篇 |
排序方式: 共有410条查询结果,搜索用时 15 毫秒
121.
122.
123.
124.
125.
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE 总被引:4,自引:0,他引:4
Ye K Aghdasi B Luo HR Moriarity JL Wu FY Hong JJ Hurt KJ Bae SS Suh PG Snyder SH 《Nature》2002,415(6871):541-544
Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain. Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. This enzymatic activity accounts for the mitogenic properties of PLC-gamma 1. 相似文献
126.
Joseph R. Holomuzki 《西北部美国博物学家》2011,43(3)
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Examination of stomach contents indicated that second-year Ambystoma tigrinum nebulosum larvae consumed Limnephilus sp. larvae but rarely ingested the case. Feeding observations of captive salamanders on caddisfly larvae supported this finding. Extraction of caddisfly larvae from their case was accomplished only when larval salamanders quickly seized the anterior portion of ambulatory Limnephilus sp. extended from their case and vigorously shook the trichopteran from side to side. 相似文献
127.
Six species of Plecoptera were maintained at four different temperatures, which were constant and higher than occurred in the natural habitat, and three species at two different day lengths. Each animal was weighed each day or each week. Weight of two species in the wild was monitored from periodic collection. The weight of each animal fluctuated rhythmically, changing about five percent every five days. These short - term fluctuations probably resulted from changes in water content. Molting occurred when a peak weight was predicted from the cycle and involved temporary gain of about 20 percent in weight. Growth probably stopped for some time before molt and was most rapid just afterward. Many animals died at molt. The time before death was less for univoltine species than for those with longer life cycles. Plecoptera collected in winter from water near 0 C lived for shorter times than did those collected in autumn from water near 10 C. Two species died sooner at higher temperatures and one died sooner with shorter day lengths. Growth in the laboratory was generally slower than in nature. One species grew faster, while three grew more slowly at higher temperatures. One species grew faster under long - than short - day conditions. Premature emergence, expected at the higher temperatures, did not occur, except in one animal. 相似文献
128.
Pryor WR Rymer AM Mitchell DG Hill TW Young DT Saur J Jones GH Jacobsen S Cowley SW Mauk BH Coates AJ Gustin J Grodent D Gérard JC Lamy L Nichols JD Krimigis SM Esposito LW Dougherty MK Jouchoux AJ Stewart AI McClintock WE Holsclaw GM Ajello JM Colwell JE Hendrix AR Crary FJ Clarke JT Zhou X 《Nature》2011,472(7343):331-333
Although there are substantial differences between the magnetospheres of Jupiter and Saturn, it has been suggested that cryovolcanic activity at Enceladus could lead to electrodynamic coupling between Enceladus and Saturn like that which links Jupiter with Io, Europa and Ganymede. Powerful field-aligned electron beams associated with the Io-Jupiter coupling, for example, create an auroral footprint in Jupiter's ionosphere. Auroral ultraviolet emission associated with Enceladus-Saturn coupling is anticipated to be just a few tenths of a kilorayleigh (ref. 12), about an order of magnitude dimmer than Io's footprint and below the observable threshold, consistent with its non-detection. Here we report the detection of magnetic-field-aligned ion and electron beams (offset several moon radii downstream from Enceladus) with sufficient power to stimulate detectable aurora, and the subsequent discovery of Enceladus-associated aurora in a few per cent of the scans of the moon's footprint. The footprint varies in emission magnitude more than can plausibly be explained by changes in magnetospheric parameters--and as such is probably indicative of variable plume activity. 相似文献
129.
130.
O'Doherty JE Lebedev MA Ifft PJ Zhuang KZ Shokur S Bleuler H Nicolelis MA 《Nature》2011,479(7372):228-231
Brain-machine interfaces use neuronal activity recorded from the brain to establish direct communication with external actuators, such as prosthetic arms. It is hoped that brain-machine interfaces can be used to restore the normal sensorimotor functions of the limbs, but so far they have lacked tactile sensation. Here we report the operation of a brain-machine-brain interface (BMBI) that both controls the exploratory reaching movements of an actuator and allows signalling of artificial tactile feedback through intracortical microstimulation (ICMS) of the primary somatosensory cortex. Monkeys performed an active exploration task in which an actuator (a computer cursor or a virtual-reality arm) was moved using a BMBI that derived motor commands from neuronal ensemble activity recorded in the primary motor cortex. ICMS feedback occurred whenever the actuator touched virtual objects. Temporal patterns of ICMS encoded the artificial tactile properties of each object. Neuronal recordings and ICMS epochs were temporally multiplexed to avoid interference. Two monkeys operated this BMBI to search for and distinguish one of three visually identical objects, using the virtual-reality arm to identify the unique artificial texture associated with each. These results suggest that clinical motor neuroprostheses might benefit from the addition of ICMS feedback to generate artificial somatic perceptions associated with mechanical, robotic or even virtual prostheses. 相似文献