X射线能量色散谱表征纳米多层膜的调制结构

提出并讨论了采用 X射线色散谱 ( EDX)技术表征纳米多层膜调制结构的原理和方法 ,对Ti N/ Nb N纳米多层膜的调制结构特征进行了表征 ,并与横截面透射电子显微镜 ( TEM)表征方法进行比较 .结果表明 ,对于多层膜的调制比 ,EDX是一种更为精确和方便的方法 .采用 EDX结合 X射线衍射 ( XRD)技术可以准确、方便地表征纳米多层膜的调制结构 .     

基于现场可编程器件的全数字成形滤波器实现

研究全数字基带成形滤波器的实现．根据数字通信中的基带传输原理，分析基带传输中成形滤波的必要性和几种常见实现方法的优缺点．选择了其中的查表法，并通过采用基于现场可编程门阵列器件的硬件描述语言，对该方法进行了全面的仿真和分析．采用该技术实现的全数字成形滤波器可以针对不同速率及指标在系统中方便地进行修改．符合未来数字通信软件化的趋势，在软件无线电中有广阔的应用前景。     

甘肃省道路货运业的运力结构调整研究

以柯布-道格拉斯生产函数为基础建立运力发展模型,定量分析甘肃省营运载货汽车数量与汽车货运量的关系,结果表明营运载货汽车处于规模回报递减和总量过剩状态,进一步说明运力结构调整的必要性.通过运力发展模型计算出满足特定需求的冷藏保温车和集装箱运输车的理论配置数量,为专用车型的投放计划提供参考.并列举了行政管理部门进行运力结构调整的政策保障.     

高分子二苯甲酮光引发剂的制备及其光化学行为研究

通过3,5-二氨基-4′-苯硫基二苯甲酮(DATBP)与六亚甲基-1,6-二异氰酸酯(HDI)及N-甲基二乙醇胺(MDEA)进行逐步聚合反应,将二苯硫醚结构及共引发剂胺结构都引入到高分子链上,从而得到侧链含有二苯硫醚和二苯甲酮,主链含有共引发剂胺的聚氨酯型高分子光引剂(PUS-HSM)。傅立叶红外变换光谱、核磁共振氢谱及凝胶渗透色谱证实了高分子光引发剂的结构。紫外光谱证实了高分子的结构对二苯甲酮单元的最大紫外吸收几乎没有影响。电子自旋共振光谱表明PUS-HSM产生自由基的效率较高。     

动-静脉途径无泵驱动的体外膜肺氧合支持疗法

对无泵驱动的动-静脉途径体外膜肺氧合支持疗法进行分析总结,并与需泵驱动的静-动脉体外膜肺氧合支持疗法进行对比,结果证明体外膜肺氧合支持疗法采取动-静脉途径比静-动脉体途径更有利．     

一种可编码的开关网络及其在自动测量中的应用

在对集成模拟开关及其主要电气性能讨论的基础上提出了一种可编码开关网络电路，分析了电路的工作原理及其简单实用等优点，并给出在接地电阻自动测量中的应用实例。     

基于SSR的广西同色兜兰和带叶兜兰遗传多样性分析

评估四季开花型同色兜兰（Paphiopedilum concolor）和春季开花型带叶兜兰（P.hirsutissimum）的遗传多样性和种群结构,探究不同开花习性兜兰属物种间的遗传分化,为兜兰的可持续利用和野生资源保护提供理论依据。本研究利用10个多态性EST-SSR位点对12个同色兜兰和带叶兜兰种群的231个个体分型,开展遗传多样性、瓶颈效应、系统发育、遗传结构、遗传分化、距离隔离和环境隔离分析。结果表明,同色兜兰种群的大多数遗传多样性指标都显著（P<0.05）低于带叶兜兰;分子方差分析（AMOVA）结果显示,两者来自种群间的变异都较少,且带叶兜兰来自个体内的遗传变异高于同色兜兰。在同色兜兰的两个种群中检测到显著（P<0.05）瓶颈效应,而在带叶兜兰全部种群中均未检测到。群体水平的非加权平均（UPGMA）树和个体水平的邻接（NJ）树均显示同色兜兰和带叶兜兰间系统发育关系相对较近,并各自聚为一支。主坐标分析（PCoA）和Structure分析结果均支持系统发育分析结果。此外,遗传分化系数（F_ST）证实两个物种间的种群分化已达到较高水平。狭窄的自然分布和过去的种群瓶颈可能导致了同色兜兰的部分遗传多样性丧失。地理隔离是驱动同色兜兰和带叶兜兰种群遗传分化的主要因素,而环境隔离的作用较小。     

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we developed a co-culture system to systematically assay the ability of 23 stromal cell types to influence the innate resistance of 45 cancer cell lines to 35 anticancer drugs. We found that stroma-mediated resistance is common, particularly to targeted agents. We characterized further the stroma-mediated resistance of BRAF-mutant melanoma to RAF inhibitors because most patients with this type of cancer show some degree of innate resistance. Proteomic analysis showed that stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI(3)K)-AKT signalling pathways, and immediate resistance to RAF inhibition. Immunohistochemistry experiments confirmed stromal cell expression of HGF in patients with BRAF-mutant melanoma and showed a significant correlation between HGF expression by stromal cells and innate resistance to RAF inhibitor treatment. Dual inhibition of RAF and either HGF or MET resulted in reversal of drug resistance, suggesting RAF plus HGF or MET inhibitory combination therapy as a potential therapeutic strategy for BRAF-mutant melanoma. A similar resistance mechanism was uncovered in a subset of BRAF-mutant colorectal and glioblastoma cell lines. More generally, this study indicates that the systematic dissection of interactions between tumours and their micro-environment can uncover important mechanisms underlying drug resistance.     

统计与规则相结合的藏文人名自动识别研究

提出了一种基于统计与规则相结合的藏文人名自动识别方法.该方法充分挖掘了人名与上下文信息的关联程度,引入互信息对关联程度进行了定量的描述.根据大规模语料(30.2 M文本语料)的统计数据所建立的规则极大地提高了识别算法的准确率;在处理汉族音译人名情况时,采用姓氏驱动的方法,很好地解决了藏文文本中汉族人名的识别问题.实验结果表明,该方法具有较高的准确率和召回率.     

A process model for BOF process based on bath mixing degree

The process model for BOF process can be applied to predict the liquid steel composition and bath temperature during the whole steelmaking process. On the basis of the traditional three-stage decarburization theory, the concept of mixing degree was put forward, which was used to indicate the effect of oxygen jet on decarburization. Furthermore, a more practical process model for BOF steelmaking was developed by analyzing the effect of silicon, manganese, oxygen injection rate, oxygen lance height, and bath temperature on decarburization. Process verification and end-point verification for the process model have been carried out, and the verification results show that the prediction accuracy of carbon content reaches 82.6% (the range of carbon content at the end-point is less than 0.1wt%) and 85.7% (the range of carbon content at end-point is 0.1wt%–0.7wt%) when the absolute error is less than 0.02wt% and 0.05wt%, respectively.