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191.
192.
Ronald Fricke 《Journal of Natural History》2016,50(47-48):3003-3028
A new species of dragonet, Synchiropus novaehiberniensis from off northern New Ireland, Papua New Guinea, is described on the basis of a male and a female specimen collected with a trawl in 74–92 m depth off Kavieng. The new species is characterized within the subgenus Synchiropus (Neosynchiropus) Nalbant, 1979 by a small branchial opening; head short (3.2–3.6 in SL); eye large (2.5–2.6 in head length); preopercular spine with a short, upcurved main tip, three curved points on its dorsal margin, ventral margin and base smooth; first dorsal fin higher than second dorsal fin, with four spines but no filaments, first spine longest; second dorsal fin distally slightly convex, with eight branched rays (last divided at base); anal fin with seven unbranched rays (last divided at base); 21–22 pectoral-fin rays; caudal fin elongate, distally rounded, slightly asymmetrical (upper rays shorter than lower rays); thorax, lower opercle and pelvic-fin base with small ocelli; back in male with four dark brown saddles; anal fin dark grey. The subgenus Synchiropus (Neosynchiropus) is reviewed and distinguished from Synchiropus (Acommissura) subgen. nov. An updated checklist of the species in the two subgenera is provided; the new species is compared with allied species. Revised keys to callionymid fish species of New Guinea, as well as of the subgenera Synchiropus (Neosynchiropus) and Synchiropus (Acommissura) subgen. nov. are presented.
http://zoobank.org/urn:lsid:zoobank.org:pub:AACA51E1-FBD6-412D-B09A-78540E7089B4 相似文献
193.
W Zhou EA Otto A Cluckey R Airik TW Hurd M Chaki K Diaz FP Lach GR Bennett HY Gee AK Ghosh S Natarajan S Thongthip U Veturi SJ Allen S Janssen G Ramaswami J Dixon F Burkhalter M Spoendlin H Moch MJ Mihatsch J Verine R Reade H Soliman M Godin D Kiss G Monga G Mazzucco K Amann F Artunc RC Newland T Wiech S Zschiedrich TB Huber A Friedl GG Slaats JA Joles R Goldschmeding J Washburn RH Giles S Levy A Smogorzewska F Hildebrandt 《Nature genetics》2012,44(8):910-915
Chronic kidney disease (CKD) represents a major health burden. Its central feature of renal fibrosis is not well understood. By exome sequencing, we identified mutations in FAN1 as a cause of karyomegalic interstitial nephritis (KIN), a disorder that serves as a model for renal fibrosis. Renal histology in KIN is indistinguishable from that of nephronophthisis, except for the presence of karyomegaly. The FAN1 protein has nuclease activity and acts in DNA interstrand cross-link (ICL) repair within the Fanconi anemia DNA damage response (DDR) pathway. We show that cells from individuals with FAN1 mutations have sensitivity to the ICL-inducing agent mitomycin C but do not exhibit chromosome breakage or cell cycle arrest after diepoxybutane treatment, unlike cells from individuals with Fanconi anemia. We complemented ICL sensitivity with wild-type FAN1 but not with cDNA having mutations found in individuals with KIN. Depletion of fan1 in zebrafish caused increased DDR, apoptosis and kidney cysts. Our findings implicate susceptibility to environmental genotoxins and inadequate DNA repair as novel mechanisms contributing to renal fibrosis and CKD. 相似文献
194.
Previous work suggested that Gambel oak seedlings are rare in the northern parts of its range in Utah where summer rainfall is relatively low but should be abundant in southern parts of the range where summer rainfall is usually high. Gambel oak grades from a relatively minor component of a ponderosa pine/mixed conifer assemblage in the south to a virtually monotypic formation in the north, where it exists as long-lived clones. Quadrat analysis in Arizona and New Mexico, within the oak zone, revealed a seedling density ranging from 120 to 1320 per hectare. We found a significant tendency of seedlings to be located on the NE (cool, shady) side of sheltering objects in the environment. Mature ponderosa pine ranged in density from ca 40 to 500 stems per hectare, whereas mature Gambel oak ranged from ca 10 to 20 genets per hectare with ca 1 to 7 ramets per clone. These results support our previous conclusion that Gambel oak in northern Utah probably became established as a minor component of a mixed pine/oak woodland at a time in mid-Holocene when summer rainfall was much higher than today. 相似文献
195.
Ronald J. Kass 《西北部美国博物学家》2011,48(1)
A checklist of the vascular plants of the House Range, Juab and Millard counties, Utah, is presented. A flora of 373 species and infraspecific taxa in 231 genera and 60 families are reported. The geology, physiography, climate, and plant communities are briefly discussed. Several endemics occur in the study area and a new taxon has been described. 相似文献
196.
Can business planning be improved if more attention is paid to underlying political cycles? This paper compares practitioner and researcher perspectives on this issue. While practioners stand to gain useful insights from a careful examination of past political cycles, these insights may be disconfirmed by rigorous tests carried out by researchers. In this paper we isolate and examine five hypotheses from the literature on the political-economic cycle. 相似文献
198.
A Bayesian procedure for forecasting S‐shaped growth is introduced and compared to classical methods of estimation and prediction using three variants of the logistic functional form and annual times series of the diffusion of music compact discs in twelve countries. The Bayesian procedure was found not only to improve forecast accuracy, using the medians of the predictive densities as point forecasts, but also to produce intervals with a width and asymmetry more in accord with the outcomes than intervals from the classical alternative. While the analysis in this paper focuses on logistic growth, the problem is set up so that the methods are transportable to other characterizations of the growth process. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
199.
Parvari R Hershkovitz E Grossman N Gorodischer R Loeys B Zecic A Mortier G Gregory S Sharony R Kambouris M Sakati N Meyer BF Al Aqeel AI Al Humaidan AK Al Zanhrani F Al Swaid A Al Othman J Diaz GA Weiner R Khan KT Gordon R Gelb BD;HRD/Autosomal Recessive Kenny-Caffey Syndrome Consortium 《Nature genetics》2002,32(3):448-452
The syndrome of congenital hypoparathyroidism, mental retardation, facial dysmorphism and extreme growth failure (HRD or Sanjad-Sakati syndrome; OMIM 241410) is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. A similar syndrome with the additional features of osteosclerosis and recurrent bacterial infections has been classified as autosomal recessive Kenny-Caffey syndrome (AR-KCS; OMIM 244460). Both traits have previously been mapped to chromosome 1q43-44 (refs 5,6) and, despite the observed clinical variability, share an ancestral haplotype, suggesting a common founder mutation. We describe refinement of the critical region to an interval of roughly 230 kb and identification of deletion and truncation mutations of TBCE in affected individuals. The gene TBCE encodes one of several chaperone proteins required for the proper folding of alpha-tubulin subunits and the formation of alpha-beta-tubulin heterodimers. Analysis of diseased fibroblasts and lymphoblastoid cells showed lower microtubule density at the microtubule-organizing center (MTOC) and perturbed microtubule polarity in diseased cells. Immunofluorescence and ultrastructural studies showed disturbances in subcellular organelles that require microtubules for membrane trafficking, such as the Golgi and late endosomal compartments. These findings demonstrate that HRD and AR-KCS are chaperone diseases caused by a genetic defect in the tubulin assembly pathway, and establish a potential connection between tubulin physiology and the development of the parathyroid. 相似文献
200.
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult 总被引:23,自引:0,他引:23
Gross C Zhuang X Stark K Ramboz S Oosting R Kirby L Santarelli L Beck S Hen R 《Nature》2002,416(6879):396-400
Serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective in treating anxiety and depression. Specifically, agonists of the serotonin1A receptor have anxiolytic properties, and knockout mice lacking this receptor show increased anxiety-like behaviour. Here we use a tissue-specific, conditional rescue strategy to show that expression of the serotonin1A receptor primarily in the hippocampus and cortex, but not in the raphe nuclei, is sufficient to rescue the behavioural phenotype of the knockout mice. Furthermore, using the conditional nature of these transgenic mice, we suggest that receptor expression during the early postnatal period, but not in the adult, is necessary for this behavioural rescue. These findings show that postnatal developmental processes help to establish adult anxiety-like behaviour. In addition, the normal role of the serotonin1A receptor during development may be different from its function when this receptor is activated by therapeutic intervention in adulthood. 相似文献