Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi

Epimastigotes of Trypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.     

Histologische Veränderungen der Magenschleimhaut des Hundes bei wiederholter Tetrachlormethanzufuhr

Summary Long-term administration of tetrachloromethane led to cirrhosis of the liver in dogs. Neither a repeated administration of the hepatotoxic substance nor cirrhotic changes of the liver led to changes of the gastric mucosa. The histological picture of the gastric mucosa was the same in dogs with liver cirrhosis as in healthy animals.     

Psychotogenic and hallucinogenic properties of large doses of benactyzine

Zusammenfassung Benactyzin in Dosen 50–200 mg löste bei 7 Versuchspersonen experimentelle Psychose mit gleichzeitiger Herabsetzung von 5-Hydroxyindolylessigsäure im Harn aus. Die psychotogene Wirkung wird mit dem Eingriff in den Serotonin- und Acetylcholinmetabolismus erklärt.     

Indirect effect of ultrasound on water permeability of the connective tissue

Zusammenfassung Die Durchlässigkeit des Rattenmesenteriums für demineralisiertes Wasser wird durch Ultraschallbehandlung des Wassers signifikant erhöht.     

Loss of redundant gene expression after polyploidization in plants

Summary Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25%, and 18% respectively.     

Esbozo de una logica interna en la obra arquimediana

Presentado por B. L. van der Waerden     

Postembryonic sensory axon guidance in Drosophila

The peripheral sensory system of the Drosophila adult has been used for the genetic analysis of axon guidance because of its accessibility for experimental manipulation and mutant screens. Wing, leg, antenna, or eye sensory axons are able to pathfind normally under different perturbations, indicating that sensory axon guidance is a highly canalized process. Similarly to other model systems, sensory growth cones seem to use multiple, simultaneous cues for guidance. In addition, sensory axons from peripheral structures seem to be capable of using alternative substrates for pathfinding. Developmental regulation could account for the high stability of axon guidance under experimental and natural perturbation conditions. Despite this flexibility, functional characterization of genes involved in sensory axon guidance is being carried out in situations where there appears to be less system redundancy.