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Savaskan NE Rocha L Kotter MR Baer A Lubec G van Meeteren LA Kishi Y Aoki J Moolenaar WH Nitsch R Bräuer AU 《Cellular and molecular life sciences : CMLS》2007,64(2):230-243
Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive
lysophosphatidic acid. Lysophosphatidic acid has been implicated in various neural cell functions such as neurite remodeling,
demyelination, survival and inhibition of axon growth. Here, we report on the in vivo expression of autotaxin in the brain during development and following neurotrauma. We found that autotaxin is expressed in
the proliferating subventricular and choroid plexus epithelium during embryonic development. After birth, autotaxin is mainly
found in white matter areas in the central nervous system. In the adult brain, autotaxin is solely expressed in leptomeningeal
cells and oligodendrocyte precursor cells. Following neurotrauma, autotaxin is strongly up-regulated in reactive astrocytes
adjacent to the lesion. The present study revealed the cellular distribution of autotaxin in the developing and lesioned brain
and implies a function of autotaxin in oligodendrocyte precursor cells and brain injuries.
Received 18 September 2006; received after revision 30 October 2006; accepted 4 December 2006 相似文献