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171.
Impact cratering creates a wide range of topography on small satellites and asteroids. The population of visible craters evolves with impacts, and because there are no competing endogenic processes to modify the surface, determining the various ways younger craters add to or subtract from the population is a fundamental aspect of small-body geology. Asteroid 433 Eros, the most closely studied small body, has regions of substantially different crater densities that remain unexplained. Here we show that the formation of a relatively young crater (7.6 km in diameter) resulted in the removal of other craters as large as 0.5 km over nearly 40 percent of the asteroid. Burial by ejecta cannot explain the observed pattern of crater removal. The limitation of reduced crater density to a zone within a particular straight-line distance through the asteroid from the centre of the large crater suggests degradation of the topography by seismic energy released during the impact. Our observations indicate that the interior of Eros is sufficiently cohesive to transmit seismic energy over many kilometres, and the outer several tens of metres of the asteroid must be composed of relatively non-cohesive material. 相似文献
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173.
Davierwala AP Haynes J Li Z Brost RL Robinson MD Yu L Mnaimneh S Ding H Zhu H Chen Y Cheng X Brown GW Boone C Andrews BJ Hughes TR 《Nature genetics》2005,37(10):1147-1152
The nature of synthetic genetic interactions involving essential genes (those required for viability) has not been previously examined in a broad and unbiased manner. We crossed yeast strains carrying promoter-replacement alleles for more than half of all essential yeast genes to a panel of 30 different mutants with defects in diverse cellular processes. The resulting genetic network is biased toward interactions between functionally related genes, enabling identification of a previously uncharacterized essential gene (PGA1) required for specific functions of the endoplasmic reticulum. But there are also many interactions between genes with dissimilar functions, suggesting that individual essential genes are required for buffering many cellular processes. The most notable feature of the essential synthetic genetic network is that it has an interaction density five times that of nonessential synthetic genetic networks, indicating that most yeast genetic interactions involve at least one essential gene. 相似文献
174.
Bruce LJ Robinson HC Guizouarn H Borgese F Harrison P King MJ Goede JS Coles SE Gore DM Lutz HU Ficarella R Layton DM Iolascon A Ellory JC Stewart GW 《Nature genetics》2005,37(11):1258-1263
We identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the hereditary stomatocytosis and spherocytosis classes. Affected individuals in these families had an increase in membrane permeability to Na and K that is particularly marked at 0 degrees C. We found that disease in these pedigrees was associated with a series of single amino-acid substitutions in the intramembrane domain of the erythrocyte band 3 anion exchanger, AE1. Anion movements were reduced in the abnormal red cells. The 'leak' cation fluxes were inhibited by SITS, dipyridamole and NS1652, chemically diverse inhibitors of band 3. Expression of the mutated genes in Xenopus laevis oocytes induced abnormal Na and K fluxes in the oocytes, and the induced Cl transport was low. These data are consistent with the suggestion that the substitutions convert the protein from an anion exchanger into an unregulated cation channel. 相似文献
175.
One-stop shop for microarray data 总被引:8,自引:0,他引:8
176.
DiTullio GR Grebmeier JM Arrigo KR Lizotte MP Robinson DH Leventer A Barry JP VanWoert ML Dunbar RB 《Nature》2000,404(6778):595-598
The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly to pCO2 drawdown in the Southern Ocean. Diatoms are assumed to be the most important phytoplankton class with respect to export production in the Southern Ocean; however, the colonial prymnesiophyte Phaeocystis antarctica regularly forms huge blooms in seasonal ice zones and coastal Antarctic waters. There is little evidence regarding the fate of carbon produced by P. antarctica in the Southern Ocean, although remineralization in the upper water column has been proposed to be the main pathway in polar waters. Here we present evidence for early and rapid carbon export from P. antarctica blooms to deep water and sediments in the Ross Sea. Carbon sequestration from P. antarctica blooms may influence the carbon cycle in the Southern Ocean, especially if projected climatic changes lead to an alteration in the structure of the phytoplankton community. 相似文献
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178.
Structure of a monomeric oxygen-carrying complex 总被引:3,自引:0,他引:3
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180.
J. G. Nievel N. Robinson Professor J. T. Eayrs 《Cellular and molecular life sciences : CMLS》1968,24(7):677-678
Zusammenfassung Im Rattenversuch wurde die Möglichkeit, dass eine Störung in der Proteinsynthese für die geistige Retardierung beim Kretinismus verantwortlich sei, untersucht. Ein Beweis dafür, dass die Funktion neuronaler Polysome durch Thyroidektomie bei der Geburt geschädigt wird, wurde nicht erbracht. 相似文献