A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Dynamics of a dwarf bear-poppy ( Arctomecon humilis ) population over a sixteen-year period

A population of the dwarf bear-poppy ( Arctomecon humilis Coville, Papaveraceae) at Red Bluff, Washington County, Utah, was monitored twice annually between 1987 and 2002. This is a narrowly endemic, gypsophilous species that has been formally listed as endangered since 1979. During the 16 years of observation, density of this species has fluctuated between 3 and 1336 individuals on the 0.07-ha monitoring plot. Moderate to large recruitments of seedlings occurred in 1992, 1995, and 2001. Seedling recruitments from a large, long-lived seed bank are triggered by abundant precipitation during the February-April period. At least 5.0 cm of rainfall is required during that interval to produce any seedlings. Seedlings experienced considerable mortality in the 1st few months of life in all observed cases. The average seedling initiated in the very large recruitment event of 1992 survived for only 2.6 years. Seedlings in that cohort that were alive 1 year after germination had an average longevity of 4.6 years. None of the seedlings that emerged in 1992 were still alive in October 2002. Mortality in this species was poorly correlated with fluctuations in precipitation or temperature. No epidemics of parasites or herbivores were observed. Mortality in the species appears to be caused by a variety of factors acting over a cohort's lifetime.     

基于人眼状态识别的驾驶员疲劳检测方法研究

提出一种基于眼睛状态识别的驾驶员疲劳状态检测的方法。首先通过建立肤色模型分割出人脸区域,再利用搜索连通域的方法实现眼睛区域的定位;然后计算出眼睛区域的垂直积分投影曲线,提取并比较曲线的特征参数,从而识别眼睛的状态;最后以眼睛闭合时间比率为测量标准实现对驾驶员疲劳程度的检测。实验表明,该方法简单、有效、实时性较好,疲劳检测的正确率较高。     

论小型公司的人力资源结构管理

组织机构相当于公司的中枢神经,掌控着公司各项功能的运转.要经营好一家公司,一定要建立一套科学、合理的组织机构体系,均衡地行使各项职能,这样才能有效处理公司发展过程中遇到的问题和困难；混沌的组织机构,只会导致公司的衰退和灭亡.     

浅谈室内绿化设计的原则与作用

随着生产力的高度发展和生活水平的日益提高,人类对绿色自然的需求也更为强烈,以至于绿色植物已发展成为室内设计中重要的一部分.在现代室内设计中,节能环保的设计理念已成为主流,合理利用自然资源,减少能源的消耗,关注健康,回归自然,扩展了室内设计的内涵,使室内设计走向更高层次和境界.     

GPS-RTK测量在公路勘察设计中的应用

近年来,GPS技术被测量界所接受.从最初只涉及控制测量和高精度的大地测量,到后来俄罗斯GLONASS定位系统的完善、国内GPS制造商的产品更新、双星接收机的出现,促使定位精度更加准确,而且随着设备价格的下降及很好的售后服务,均给GPS的普及作了极大铺垫,使得GPS-RTK测量技术遍及测量领域.     

高职院校困难学生心理危机干预的策略研究

高职学生安全管理体系是一个复杂系统,困难学生心理危机干预体系是高职学生安全管理系统的内容之一。困难学生群体因家庭困难、自尊心强、心理负担重、易受外界伤害等特点自身易诱发心理危机。学校应构建困难学生心理危机干预体系,当心理危机出现时,学生安全管理系统应给予及时、有效、准确的干预和帮扶。     

Optical detection of acetylcholine esterase based on CdTe quantum dots

In this study, we have constructed a simple, sensitive and rapid biosensor for detection of acetylcholine esterase (AChE) based on CdTe quantum dots (QDs). The detection limit of AChE by one-step enzyme reaction based on the thiolglycolic acid (TGA) stabilized QDs (TGA-QDs) was 10 U/L and the linear range was 10-100 and 100-1200 U/L, respectively. The detection limit of AChE by two-step enzyme reaction based on the 3-mercaptopropionic acid (MGA) stabilized QDs (MGA-QDs) was found to be 20 U/L and the linear range was 100-2500 U/L. The experimental conditions of biosensors were optimized, and the detection mechanism was studied. We also detected AChE in serum samples based on TGA-QDs or MGA-QDs. The linear range was 10-140 and 50-1000 U/L, respectively. The excellent performance of this novel biosensor demonstrated that this strategy has prodigious potential to be applied in practice detection of AChE.     

汾河流域降水量及蒸发量的空间变异性分析研究

借助于地质统计学方法对汾河流域的多年平均降雨量和蒸发量的空间变异性进行了分析,揭示了多年平均降水量和蒸发量的空间变异特征,并应用Kriging方法进行空间插值.分析结果表明,汾河流域多年平均降水量和蒸发量在不同的分割距离范围内有不同的空间相关性,多年平均降水量具有比较明显的地带性,蒸发量分布变化地带性不强.