Human inquiry: Steps towards emancipatory practice

In this paper we explore the contribution of work in Human Inquiry to the debate about what might constitute authentic emancipatory practice and about how such an ideal might be approached. We beghin by considering some key values, issues, and commitments which characterise this work and distinguish it from other established research traditions. A number of distinct approaches to the practice of human inquiry have been articulated. These are referred to but it is not our purpose to review particular approaches in detail here. Rather our aim is to move from this overview of human inquiry to consider some important implications for practice. In particular, we look at Bateson's theory of levels of learning and explore ways in which both the intellectual and the more personal frameworks of participants can contribute to, and at times impede, the kinds of mutual learning with which human inquiries are concerned. We illustrate this discussion by drawing on examples from our own work in human inquiry. Here we aim to highlight particular implications and issues that might arise within human inquiries. One source of illustrations is Peter's work with general and complementary practitioners in a primary health care centre, the other is Anne's work with UWE student groups acting as consultants for local community organisations. In each case we consider some origins, forms, and expressions of power differences and show how empowerment can occur as participants learn within and across Bateson's levels as inquiries progress. We conclude by summarising the evidence of and opportunities for empowerment in each case and by showing how a deeper appreciation of Bateson's levels of learning can further understanding of the nature of emancipatory practice. Finally, we make more general suggestions about the role of approaches to Human Inquiry in future emancipatory practice.     

Churchman's “anatomy of system teleology” revisited

Churchman's concept of “inquiring systems” and its underlying “anatomy of system teleology” have been a source of inspiration for the development of Peter B. Checkland's Soft Systems Methodology. The author here provides a personal account of the importance that Churchman's approach has had for him. In the spirit of Singerian inquiry, he also offers a few critical considerations with respect to the assumptions and limitations of Churchman's teleological system approach. (Editor)     

危机期间践行良好的科学

 科学共同体是人类文明中一种特有的组织，是科学家在科学活动中通过相对稳定的联系而结成的组织和团体，是集体科学劳动的一般社会存在形式。科学发展极大地推动了社会进步，科学与社会的联系比过去更加紧密，科学共同体的社会责任也在不断增强，本次新冠肺炎疫情在全球形势严峻，也暴露出科学共同体开展推进开放合作的迫切性。发展科学知识、服务人类社会是科学共同体的价值担当，也是科技期刊和出版机构应承担的责任。面对抗击新冠肺炎疫情的重大挑战，在疫情爆发之时，作为科技期刊和出版商，我认为在危急时刻，科技期刊和出版商在信息处理方面的表现尤为重要，要保证信息的可发现性、具备能快速应对大量的信息的能力以及确保信息有价值。     

Earthquakes triggered by silent slip events on Kīlauea volcano, Hawaii

Slow-slip events, or 'silent earthquakes', have recently been discovered in a number of subduction zones including the Nankai trough in Japan, Cascadia, and Guerrero in Mexico, but the depths of these events have been difficult to determine from surface deformation measurements. Although it is assumed that these silent earthquakes are located along the plate megathrust, this has not been proved. Slow slip in some subduction zones is associated with non-volcanic tremor, but tremor is difficult to locate and may be distributed over a broad depth range. Except for some events on the San Andreas fault, slow-slip events have not yet been associated with high-frequency earthquakes, which are easily located. Here we report on swarms of high-frequency earthquakes that accompany otherwise silent slips on Kīlauea volcano, Hawaii. For the most energetic event, in January 2005, the slow slip began before the increase in seismicity. The temporal evolution of earthquakes is well explained by increased stressing caused by slow slip, implying that the earthquakes are triggered. The earthquakes, located at depths of 7-8 km, constrain the slow slip to be at comparable depths, because they must fall in zones of positive Coulomb stress change. Triggered earthquakes accompanying slow-slip events elsewhere might go undetected if background seismicity rates are low. Detection of such events would help constrain the depth of slow slip, and could lead to a method for quantifying the increased hazard during slow-slip events, because triggered events have the potential to grow into destructive earthquakes.     

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal-onset multiple-system inflammatory disease. Cryopyrin (also called Nalp3), the product of CIAS1, is a member of the NOD-LRR protein family that has been linked to the activation of intracellular host defence signalling pathways. Cryopyrin forms a multi-protein complex termed 'the inflammasome', which contains the apoptosis-associated speck-like protein (ASC) and caspase-1, and promotes caspase-1 activation and processing of pro-interleukin (IL)-1beta (ref. 4). Here we show the effect of cryopyrin deficiency on inflammasome function and immune responses. Cryopyrin and ASC are essential for caspase-1 activation and IL-1beta and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 and R848. In contrast, secretion of tumour-necrosis factor-alpha and IL-6, as well as activation of NF-kappaB and mitogen-activated protein kinases (MAPKs) were unaffected by cryopyrin deficiency. Furthermore, we show that Toll-like receptors and cryopyrin control the secretion of IL-1beta and IL-18 through different intracellular pathways. These results reveal a critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes.     

Strained silicon as a new electro-optic material

For decades, silicon has been the material of choice for mass fabrication of electronics. This is in contrast to photonics, where passive optical components in silicon have only recently been realized. The slow progress within silicon optoelectronics, where electronic and optical functionalities can be integrated into monolithic components based on the versatile silicon platform, is due to the limited active optical properties of silicon. Recently, however, a continuous-wave Raman silicon laser was demonstrated; if an effective modulator could also be realized in silicon, data processing and transmission could potentially be performed by all-silicon electronic and optical components. Here we have discovered that a significant linear electro-optic effect is induced in silicon by breaking the crystal symmetry. The symmetry is broken by depositing a straining layer on top of a silicon waveguide, and the induced nonlinear coefficient, chi(2) approximately 15 pm V(-1), makes it possible to realize a silicon electro-optic modulator. The strain-induced linear electro-optic effect may be used to remove a bottleneck in modern computers by replacing the electronic bus with a much faster optical alternative.