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Mycorrhizas in ecosystems 总被引:35,自引:0,他引:35
D. J. Read 《Cellular and molecular life sciences : CMLS》1991,47(4):376-391
Summary The results of analyses of the distribution, structure and function of ericoid, ecto and vesicular-arbuscular mycorrhizas are used to challenge the conventional view, which was based largely upon studies of isolated plants and excised plant roots under controlled conditions, that the symbiosis is primarily involved in the capture of phosphate ions. In nature, each mycorrhizal type is associated with an ecosystem and soil environment with distinctive characteristics in which selection has favoured the development of a particular range of attributes. These attributes are evaluated and their importance for the individual plant and for the ecosystems in which they occur is assessed. It is concluded that knowledge of the full range of functions of each mycorrhizal type is essential for an understanding of the distribution and dynamics of the ecosystem in which it predominates. 相似文献
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Involvement of Akt in neurite outgrowth 总被引:1,自引:1,他引:0
Danielle E. Read Adrienne M. Gorman 《Cellular and molecular life sciences : CMLS》2009,66(18):2975-2984
The regulation of neuronal differentiation and neurite outgrowth is essential during development of the nervous system and
is crucial in developing therapies to promote axon regeneration after nerve injury or in neurodegenerative diseases. The serine/threonine
kinase Akt has been well documented to promote neuronal survival. More recently Akt has also been revealed as key mediator
of several aspects of neurite outgrowth, including elongation, branching and calibre. Downstream of Akt, several substrates
have been identified that are likely to play key roles in Akt-mediated neurite outgrowth, such as glycogen synthase kinase
3β, peripherin, mammalian target of rapamycin and δ-catenin. The physical interaction between Akt and Hsp27, another protein
that has been linked with neurite outgrowth, may also be significant in the process of neurite outgrowth. This review will
unite and discuss the research to date that has examined the functionality of Akt in neuronal differentiation during development
and neurite outgrowth. 相似文献
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Structure of a serpin-protease complex shows inhibition by deformation 总被引:34,自引:0,他引:34
The serpins have evolved to be the predominant family of serine-protease inhibitors in man. Their unique mechanism of inhibition involves a profound change in conformation, although the nature and significance of this change has been controversial. Here we report the crystallographic structure of a typical serpin-protease complex and show the mechanism of inhibition. The conformational change is initiated by reaction of the active serine of the protease with the reactive centre of the serpin. This cleaves the reactive centre, which then moves 71 A to the opposite pole of the serpin, taking the tethered protease with it. The tight linkage of the two molecules and resulting overlap of their structures does not affect the hyperstable serpin, but causes a surprising 37% loss of structure in the protease. This is induced by the plucking of the serine from its active site, together with breakage of interactions formed during zymogen activation. The disruption of the catalytic site prevents the release of the protease from the complex, and the structural disorder allows its proteolytic destruction. It is this ability of the conformational mechanism to crush as well as inhibit proteases that provides the serpins with their selective advantage. 相似文献
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Activation of the protein C3 into C3b in the complement pathway is a crucial step in the complement immune response against pathogenic, immunogenic and apoptotic particles. Ajees et al. describe a crystal structure for C3b that deviates from the one reported by Janssen et al. and by Wiesmann et al.. We have reanalysed the data deposited by Ajees et al. and have discovered features that are inconsistent with the known physical properties of macromolecular structures and their diffraction data. Our findings therefore call into question the crystal structure for C3b reported by Ajees et al.. 相似文献
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Tarpey P Thomas S Sarvananthan N Mallya U Lisgo S Talbot CJ Roberts EO Awan M Surendran M McLean RJ Reinecke RD Langmann A Lindner S Koch M Jain S Woodruff G Gale RP Bastawrous A Degg C Droutsas K Asproudis I Zubcov AA Pieh C Veal CD Machado RD Backhouse OC Baumber L Constantinescu CS Brodsky MC Hunter DG Hertle RW Read RJ Edkins S O'Meara S Parker A Stevens C Teague J Wooster R Futreal PA Trembath RC Stratton MR Raymond FL Gottlob I 《Nature genetics》2006,38(11):1242-1244
Idiopathic congenital nystagmus is characterized by involuntary, periodic, predominantly horizontal oscillations of both eyes. We identified 22 mutations in FRMD7 in 26 families with X-linked idiopathic congenital nystagmus. Screening of 42 singleton cases of idiopathic congenital nystagmus (28 male, 14 females) yielded three mutations (7%). We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability. 相似文献
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The advent of 33P nucleotide triphosphates has widened the options available for labelling nucleic acids. Choosing the most appropriate label requires a careful consideration of experimental needs and circumstances. 相似文献
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Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis 总被引:22,自引:0,他引:22
Toomes C James J Wood AJ Wu CL McCormick D Lench N Hewitt C Moynihan L Roberts E Woods CG Markham A Wong M Widmer R Ghaffar KA Pemberton M Hussein IR Temtamy SA Davies R Read AP Sloan P Dixon MJ Thakker NS 《Nature genetics》1999,23(4):421-424
Papillon-Lefèvre syndrome, or keratosis palmoplantaris with periodontopathia (PLS, MIM 245000), is an autosomal recessive disorder that is mainly ascertained by dentists because of the severe periodontitis that afflicts patients. Both the deciduous and permanent dentitions are affected, resulting in premature tooth loss. Palmoplantar keratosis, varying from mild psoriasiform scaly skin to overt hyperkeratosis, typically develops within the first three years of life. Keratosis also affects other sites such as elbows and knees. Most PLS patients display both periodontitis and hyperkeratosis. Some patients have only palmoplantar keratosis or periodontitis, and in rare individuals the periodontitis is mild and of late onset. The PLS locus has been mapped to chromosome 11q14-q21 (refs 7, 8, 9). Using homozygosity mapping in eight small consanguineous families, we have narrowed the candidate region to a 1.2-cM interval between D11S4082 and D11S931. The gene (CTSC) encoding the lysosomal protease cathepsin C (or dipeptidyl aminopeptidase I) lies within this interval. We defined the genomic structure of CTSC and found mutations in all eight families. In two of these families we used a functional assay to demonstrate an almost total loss of cathepsin C activity in PLS patients and reduced activity in obligate carriers. 相似文献