远源地下水入侵阿拉善高原沙漠:酸溶物Sr同位素证据

选取北方西－东向气候剖面上物质组成相似的四个沙漠（塔克拉玛干、巴丹吉林、腾格里和毛乌素）,测定其地表沙酸溶物87Sr/86Sr比值、Ca2+和Sr2+浓度。Ca2+和Sr2+浓度相关性极好,在降雨量低的塔克拉玛干沙漠中最高,向东逐渐降低,在降雨量多的毛乌素沙漠中最低。降雨量是控制阳离子浓度变化的主导因素。酸溶物87Sr/86Sr比值在四个沙漠中有不同于阳离子变化的区域特征。塔克拉玛干沙漠酸溶物87Sr/86Sr比值在0.71以下,巴丹吉林和腾格里沙漠的大于0.7112,而毛乌素沙漠的在0.71-0.7112之间变化。塔克拉玛干和毛乌素沙漠地表沙酸溶物87Sr/86Sr比值仅受气候变化的制约。巴丹吉林和腾格里沙漠除了受气候因素影响外还受其它因素的制约,最可能的就是远源地下水。经计算,远源地下水对巴丹吉林沙漠的影响份额为47%,对腾格里沙漠为44%,接近气候因素的影响。     

论鄂西南岩溶洞穴发育与第四纪冰期和间冰期的关系

本文简述了鄂西南利川市东北部岩溶洞穴体系上、中、下层状溶洞发育状况,论述了其发育过程与第四纪冰期和间冰期的关系,在间冰期时形成水平溶洞,在冰期时形成垂直溶洞,二者互相贯通,形成了岩溶洞穴体系。     

科技期刊在科技成果转化方面的作用

结合自身办刊经验,说明科技期刊在科技成果转化中可以发挥重要作用并可提供多方位的信息服务。     

基于分级规划的加工方法排序规则研究

结合工艺决策的分级规划策略,构造了一种新的实用化的加工方法排序规则,该排序规则将传统排序规则分解成两个相关的部分：工序排序规则与工步排序规则．工序排序规则代表了排序规则的普遍性,描述了一类零件的总体加工过程,只与加工方法有关,与组成零件的形状特征等其他因素无关;工步排序规则代表了排序规则的特殊性,描述了工序中各特征的加工顺序,与特征有关而与加工方法无关．     

基于颗粒阻尼的超结构在管状带式输送机中的应用

为了减少管状带式输送机启机后产生的振动所带来的不利影响,现设计一种颗粒阻尼型声子晶体板。通过有限元法对声子晶体带隙成因进行研究,并对颗粒阻尼型声子晶体板进行建模。利用COMSOL得到颗粒阻尼型声子晶体的能带与传递损失图形,并对非颗粒阻尼型声子晶体与颗粒阻尼型声子晶体进行传递损失分析。实验结果表明,颗粒型声子晶体减振效果达到70.43%,相比非颗粒型声子晶体增加37.42%。研究结果为颗粒阻尼型声子晶体在管带机上的减振应用提供理论支撑。     

Generalized ridge estimation of a semiparametric regression model

We considered the following semiparametric regres-sion model yi = X iT β+ s ( t i ) + ei (i =1,2,,n). First,the general-ized ridge estimators of both parameters and non-parameters are given without a restrained design matrix. Second,the generalized ridge estimator will be compared with the penalized least squares estimator under a mean squares error,and some conditions in which the former excels the latter are given. Finally,the validity and feasibility of the method is illustrated by a simulation example.     

试论现代青花艺术的时代性

现代青花艺术是对传统青花艺术的延续和发展,是在继承传统青花艺术的基础上进行了取舍,融会了现代人的审美理念、创作思想及表现方法,体现新时代特征的青花艺术作品。时代不断发展,青花装饰也与时俱进,在继承传统的基础上,现代青花装饰向着多元化、自由化、个性化的方向发展,在现代青花艺术的各个方面都有充分的体现。     

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies. Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes including chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML) and secondary AML (sAML). We show here that TET2 mutations associated with myeloid malignancies compromise catalytic activity. Bone marrow samples from patients with TET2 mutations displayed uniformly low levels of 5hmC in genomic DNA compared to bone marrow samples from healthy controls. Moreover, small hairpin RNA (shRNA)-mediated depletion of Tet2 in mouse haematopoietic precursors skewed their differentiation towards monocyte/macrophage lineages in culture. There was no significant difference in DNA methylation between bone marrow samples from patients with high 5hmC versus healthy controls, but samples from patients with low 5hmC showed hypomethylation relative to controls at the majority of differentially methylated CpG sites. Our results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis. Measurement of 5hmC levels in myeloid malignancies may prove valuable as a diagnostic and prognostic tool, to tailor therapies and assess responses to anticancer drugs.