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341.
插装阀组集成控制液压系统瞬时失效机理解析 总被引:2,自引:0,他引:2
为从理论上揭示插装阀组集成控制液压系统瞬时失效的原因,以混凝土泵液压系统为例,提出了基于流体逻辑理论的插装阀组启闭状态组合的解析方法,并运用混凝土泵液压系统的数字化模型验证其有效性.研究结果表明,当负载处于一定范围时,个别插装阀的不当开启会导致不同插装阀的容腔短暂串通,造成液压系统的瞬时失效,而增加插装阀控制腔压力可以... 相似文献
342.
变压器是指用来改变交流电压大小的一种电气设备。它是根据电磁感应的设计原理,把某一等级交流的电压变换成另一等级交流的电压,从而满足不同负荷的需要。变压器不论在工作还是在生活中都有非常重要的作用,而且越来越得到广泛的应用和推广。其安全可靠性也是变压器发展的最大瓶颈,因此变压器在电力系统、供用电系统等各大系统中都占有举足轻重的作用。文章就变压器的设计原则、原理特点进行一定的探讨。 相似文献
343.
Cederwall B Moradi FG Bäck T Johnson A Blomqvist J Clément E de France G Wadsworth R Andgren K Lagergren K Dijon A Jaworski G Liotta R Qi C Nyakó BM Nyberg J Palacz M Al-Azri H Algora A de Angelis G Ataç A Bhattacharyya S Brock T Brown JR Davies P Di Nitto A Dombrádi Z Gadea A Gál J Hadinia B Johnston-Theasby F Joshi P Juhász K Julin R Jungclaus A Kalinka G Kara SO Khaplanov A Kownacki J La Rana G Lenzi SM Molnár J Moro R Napoli DR Singh BS Persson A Recchia F Sandzelius M Scheurer JN Sletten G 《Nature》2011,469(7328):68-71
Shell structure and magic numbers in atomic nuclei were generally explained by pioneering work that introduced a strong spin-orbit interaction to the nuclear shell model potential. However, knowledge of nuclear forces and the mechanisms governing the structure of nuclei, in particular far from stability, is still incomplete. In nuclei with equal neutron and proton numbers (N = Z), enhanced correlations arise between neutrons and protons (two distinct types of fermions) that occupy orbitals with the same quantum numbers. Such correlations have been predicted to favour an unusual type of nuclear superfluidity, termed isoscalar neutron-proton pairing, in addition to normal isovector pairing. Despite many experimental efforts, these predictions have not been confirmed. Here we report the experimental observation of excited states in the N = Z = 46 nucleus (92)Pd. Gamma rays emitted following the (58)Ni((36)Ar,2n)(92)Pd fusion-evaporation reaction were identified using a combination of state-of-the-art high-resolution γ-ray, charged-particle and neutron detector systems. Our results reveal evidence for a spin-aligned, isoscalar neutron-proton coupling scheme, different from the previous prediction. We suggest that this coupling scheme replaces normal superfluidity (characterized by seniority coupling) in the ground and low-lying excited states of the heaviest N = Z nuclei. Such strong, isoscalar neutron-proton correlations would have a considerable impact on the nuclear level structure and possibly influence the dynamics of rapid proton capture in stellar nucleosynthesis. 相似文献
344.
345.
Zuber J Shi J Wang E Rappaport AR Herrmann H Sison EA Magoon D Qi J Blatt K Wunderlich M Taylor MJ Johns C Chicas A Mulloy JC Kogan SC Brown P Valent P Bradner JE Lowe SW Vakoc CR 《Nature》2011,478(7370):524-528
Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in principle, reversible and often amenable to drug intervention, the promise of targeting such pathways therapeutically has been limited by an incomplete understanding of cancer-specific dependencies on epigenetic regulators. Here we describe a non-biased approach to probe epigenetic vulnerabilities in acute myeloid leukaemia (AML), an aggressive haematopoietic malignancy that is often associated with aberrant chromatin states. By screening a custom library of small hairpin RNAs (shRNAs) targeting known chromatin regulators in a genetically defined AML mouse model, we identify the protein bromodomain-containing 4 (Brd4) as being critically required for disease maintenance. Suppression of Brd4 using shRNAs or the small-molecule inhibitor JQ1 led to robust antileukaemic effects in vitro and in vivo, accompanied by terminal myeloid differentiation and elimination of leukaemia stem cells. Similar sensitivities were observed in a variety of human AML cell lines and primary patient samples, revealing that JQ1 has broad activity in diverse AML subtypes. The effects of Brd4 suppression are, at least in part, due to its role in sustaining Myc expression to promote aberrant self-renewal, which implicates JQ1 as a pharmacological means to suppress MYC in cancer. Our results establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in AML and, potentially, other cancers, and highlight the utility of RNA interference (RNAi) screening for revealing epigenetic vulnerabilities that can be exploited for direct pharmacological intervention. 相似文献
346.
Although the question of to whom a male directs his mating attempts is a critical one in social interactions, little is known about the molecular and cellular mechanisms controlling mammalian sexual preference. Here we report that the neurotransmitter 5-hydroxytryptamine (5-HT) is required for male sexual preference. Wild-type male mice preferred females over males, but males lacking central serotonergic neurons lost sexual preference although they were not generally defective in olfaction or in pheromone sensing. A role for 5-HT was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (Tph2), which is required for the first step of 5-HT synthesis in the brain. Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males. These results indicate that 5-HT and serotonergic neurons in the adult brain regulate mammalian sexual preference. 相似文献
347.
利用水热合成法制备CaWO4∶Eu3+以及CaWO4∶Eu3+,M3+(M=Tb,Sm,Bi,Dy)系列钨酸盐基荧光粉,利用XRD表征产物CaWO4∶Eu3+(5%)的晶体结构,结果表明其结构和CaWO4的标准物相结构相似,为四方晶系结构;研究了CaWO4∶Eu3+的发光性能以及第二掺杂离子M3+(M=Tb,Sm,Bi... 相似文献
348.
对南江峡谷公园不同生境陆生软体动物的物种多样性进行了研究,在4个不同生境中进行了定量调查和采集,共获5 000余号标本,经鉴定,得65种,隶属于2个亚纲2目11科36属。多样性分析结果表明:4种不同生境的物种丰富度指数DMA的取值范围在1.092~4.492之间,多样性指数H′的范围是0.812~0.903,均匀度指数Jsw为0.250~0.505。根据不同生境物种的相似性系数CC进行系统聚类,4种生境在相似性系数为0.250水平时以被归并为两组,即原生森林组和次生环境组。原生森林一旦遭受彻底破坏,其内原有的陆生贝类物种种类和数量将会显著下降。 相似文献
349.
医院护理智能化监控系统的设计 总被引:1,自引:0,他引:1
系统采用分布式计算机控制系统结构,利用RS485总线实现医护工作站(上位机)和病房监控系统(下位机)之间的信息传输。下位机以单片机AT89C51为核心,实现对患者的血压、心率和体温检测以及滴速检测和控制;监测结果显示并发送上位机。上位机以广泛使用的微机作为多床位的监控中心;建立医护数据库;接收从下位机传输的滴速、血压、心率、体温等数据,并显示、保存、分析统计,而且可以设定滴速对下位机实施控制。该系统的研制,将进一步提高医院护理和管理的自动化水平。 相似文献
350.
TiO2陶砂光催化材料的制备及对有机物降解的研究 总被引:1,自引:1,他引:0
以粘土和生石灰为主要材料,制备出陶砂材料后,在其上用溶胶-凝胶法涂敷了一层TiO2薄膜,制备成TiO2陶砂光催化材料,将其应用于降解水中有机污染物.结果表明,在热处理温度为350℃条件下,制备的TiO2光催化剂水处理效果较好,可使水中有机物的TOC值降低80%以上. 相似文献