全文获取类型
收费全文 | 184篇 |
免费 | 12篇 |
国内免费 | 11篇 |
专业分类
系统科学 | 7篇 |
现状及发展 | 86篇 |
研究方法 | 16篇 |
综合类 | 94篇 |
自然研究 | 4篇 |
出版年
2022年 | 3篇 |
2021年 | 4篇 |
2019年 | 2篇 |
2018年 | 9篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 2篇 |
2014年 | 13篇 |
2013年 | 3篇 |
2012年 | 9篇 |
2011年 | 13篇 |
2010年 | 5篇 |
2009年 | 3篇 |
2008年 | 9篇 |
2007年 | 8篇 |
2006年 | 4篇 |
2005年 | 6篇 |
2004年 | 7篇 |
2003年 | 2篇 |
2002年 | 6篇 |
1996年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 7篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1968年 | 5篇 |
1967年 | 3篇 |
1963年 | 1篇 |
1962年 | 2篇 |
1959年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有207条查询结果,搜索用时 15 毫秒
21.
A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm 总被引:13,自引:0,他引:13
Kumar R Wang RA Mazumdar A Talukder AH Mandal M Yang Z Bagheri-Yarmand R Sahin A Hortobagyi G Adam L Barnes CJ Vadlamudi RK 《Nature》2002,418(6898):654-657
Oestrogen receptor (ER) is a good prognostic marker for the treatment of breast cancers. Upregulation of metastatic tumour antigen 1 (MTA1) is associated with the invasiveness and metastatic potential of several human cancers and acts as a co-repressor of nuclear ER-alpha. Here we identify a naturally occurring short form of MTA1 (MTA1s) that contains a previously unknown sequence of 33 amino acids with an ER-binding motif, Leu-Arg-Ile-Leu-Leu (LRILL). MTA1s localizes in the cytoplasm, sequesters ER in the cytoplasm, and enhances non-genomic responses of ER. Deleting the LRILL motif in MTA1s abolishes its co-repressor function and its interaction with ER, and restores nuclear localization of ER. Dysregulation of human epidermal growth factor receptor-2 in breast cancer cells enhances the expression of MTA1s and the cytoplasmic sequestration of ER. Expression of MTA1s in breast cancer cells prevents ligand-induced nuclear translocation of ER and stimulates malignant phenotypes. MTA1s expression is increased in human breast tumours with no or low nuclear ER. The regulation of the cellular localization of ER by MTA1s represents a mechanism for redirecting nuclear receptor signalling by nuclear exclusion. 相似文献
22.
23.
D. S. Kumar 《Cellular and molecular life sciences : CMLS》1981,37(9):962-963
Summary Ovariectomy reduced the respiratory rates of liver and skeletal muscle homogenates of the Indian garden lizard,Calotes versicolor. Administration of oestradiol dipropionate elevated the rate of tissue respiration of ovariectomized animals. This finding lends support to the view that oestradiol, like testosterone, is able to stimulate the oxidative metabolism of this animal.Part of a thesis qualified for the award of Ph.D. degree of Banaras Hindu University, Varanasi, India. The author expresses his deep sense of gratitude to Professor J. P. Thapliyal of the Department of Zoology, Banaras Hindu University for valuable guidance and constant inspiration. Financial assistance was provided by a Council of Scientific and Industrial Research (New Delhi) Junior Research Fellowship. 相似文献
24.
A silver binding protein (Ag BP) has been identified in the liver of sparrows administered a tracer dose of 110mAg. The protein as purified by gel-filtration shows a major absorption maximum at 260 nm and a minor one at 225 nm. It has a mol.wt of 9500 daltons and is stable when exposed to high temperature (64 degrees C for 15 min) as well as to acidic pH (2.2). 相似文献
25.
26.
27.
The Cascadia subduction zone is thought to be capable of generating major earthquakes with moment magnitude as large as M(w) = 9 at an interval of several hundred years. The seismogenic portion of the plate interface is mostly offshore and is currently locked, as inferred from geodetic data. However, episodic surface displacements-in the direction opposite to the long-term deformation motions caused by relative plate convergence across a locked interface-are observed about every 14 months with an unusual tremor-like seismic signature. Here we show that these tremors are distributed over a depth range exceeding 40 km within a limited horizontal band. Many occurred within or close to the strong seismic reflectors above the plate interface where local earthquakes are absent, suggesting that the seismogenic process for tremors is fluid-related. The observed depth range implies that tremors could be associated with the variation of stress field induced by a transient slip along the deeper portion of the Cascadia interface or, alternatively, that episodic slip is more diffuse than originally suggested. 相似文献
28.
Summary The toxic effects of Temik (aldicarb) on a fresh water Himalyan lake teleost,Barbus conchonius were investigated in hard and soft water. The 48-, 72- and 96-h TLm-values in mg/l were 8.99, 2.39 and 2.42 respectively in the hard-water test and 3.30, 0.62 and 0.46 in the soft-water test. The toxicity of Temik toB. conchonius increases many fold in soft water.One of us (S. C. P.) is grateful to U. G. C., for the award of a senior research fellowship. 相似文献
29.
30.
Silica nanoparticles have been prepared from tetraethylorthosilicate dissolved in ethanol followed by base-catalyzed condensation.Earlier works reported that at least four parameters,namely concentrati... 相似文献