条形不耦合平面布药技术在硐室爆破中的应用

为了研究条形药包硐室爆破在复杂环境下的应用问题,首先分析了条形药包的作用机理,根据已有硐室爆破平面药包布设的半理论丰经验公式,建立了条形药包平面布设数学模型。并通过工程实例将条形药包布设理论运用于平面布药实践,缩短了平面布设条形药包的设计周期。研究表明,在山体爆破中采用条形不耦合平面布药技术能显著提高有效松动率,降低大块率,减少二次爆破量。同时也减小了爆破振动对周边环境的破坏影响。     

Loewner矩阵Moore-Penrose逆的快速算法

给出了求以秩为n的m×n阶Loewner矩阵Moore-Penrose逆的快速算法,该算法的计算复杂度为O(mn) O(n2)。     

企业R&D项目最佳组合及中止决策

从系统观点论述了对正在实施的 R& D项目进行中止决策的重要意义及中止决策的主要研究内容 .提出了确定企业 R& D项目最佳中止比例的三阶段数学模型 .进而 ,将该模型与模糊综合评判方法相结合来确定应被中止 R& D项目并给出一个案例.     

A mixed-model approach for genome-wide association studies of correlated traits in structured populations

Genome-wide association studies (GWAS) are a standard approach for studying the genetics of natural variation. A major concern in GWAS is the need to account for the complicated dependence structure of the data, both between loci as well as between individuals. Mixed models have emerged as a general and flexible approach for correcting for population structure in GWAS. Here, we extend this linear mixed-model approach to carry out GWAS of correlated phenotypes, deriving a fully parameterized multi-trait mixed model (MTMM) that considers both the within-trait and between-trait variance components simultaneously for multiple traits. We apply this to data from a human cohort for correlated blood lipid traits from the Northern Finland Birth Cohort 1966 and show greatly increased power to detect pleiotropic loci that affect more than one blood lipid trait. We also apply this approach to an Arabidopsis thaliana data set for flowering measurements in two different locations, identifying loci whose effect depends on the environment.     

An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations

Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but they do not always account for loci of larger effect. Here we propose a multi-locus mixed model as a general method for mapping complex traits in structured populations. Simulations suggest that our method outperforms existing methods in terms of power as well as false discovery rate. We apply our method to human and Arabidopsis thaliana data, identifying new associations and evidence for allelic heterogeneity. We also show how a priori knowledge from an A. thaliana linkage mapping study can be integrated into our method using a Bayesian approach. Our implementation is computationally efficient, making the analysis of large data sets (n > 10,000) practicable.     

室内人体移动过程对热舒适的影响研究

使用计算流体力学(CFD)技术,结合动网格技术和刚体运动学理论,对室内人体移动进行了动态模拟,得到了人体移动过程中不同时刻室内流场分布.分析了移动过程中的平均温度、平均速度、温度和速度不均匀性指标,并预测了有效吹风温度(TEDT)、空气分布特性指标(ADPI)和吹风感的不满意率指标(PD),比较了不同人体移动速度对以上指标的影响.模拟结果表明,人体移动对室内气流分布和热舒适有短期影响,能提高室内风速的扰动,造成吹风感.     

一种基于免疫抗体聚类算法的复杂函数寻优

通过在克隆选择过程中引入抗体聚类机制,提出了一种用于复杂多模函数优化的新算法.通过聚类将抗体群分成多个子种群来实现其克隆选择策略,加速克隆扩增,从而提高抗体成熟力及亲和性.采用了混合超变异算子,使其能快速获取全局及局部最优.实验仿真结果表明:该算法对复杂函数寻优的过程是相当有效的,具备良好的全局和局部收敛可靠性.     

基于Hurst指数的飞机完好率混沌时序数据时滞性分析

通过研究Hurst指数随时间变化曲线的特性,提出了一种计算和判断混沌时间序列平均最大“记忆”长度(“平均循环周期”)的方法。并应用于对飞机完好率时间序列数据的时滞性实证分析,分析结果得到了有关专家的认可,为进一步的评价分析奠定了基础。     

燃烧室新型迷宫复合冷却结构冷却比较

以燃烧室新型迷宫复合冷却结构为研究对象,取燃烧室新型迷宫复合冷却结构的一块瓦块,并在某型航空发动机原型气膜冷却火焰筒相同位置切出尺寸相等的1块,在流量、吹风比与实际流场相同的条件下分别对它们的三维流场和壁温进行了数值模拟,获得了其壁温及冷却效率的分布规律,并与原型火焰筒进行了对比。研究表明:相对某型航空发动机燃烧室原型火焰筒,该冷却结构的冷却效率高,流场分布均匀,温度梯度小。     

浅谈高校图书馆的创新服务

通过分析高等学校图书馆读者对象的需求变化,阐述了图书馆传统管理模式面临的主要问题,探讨了图书馆在服务上不断创新、不断提高、不断延伸的必要性和可行性。