药物分子对接网格研究与进展

药物分子对接所涉及的搜索空间非常巨大,需要耗费大量的时间,并且对计算环境也有较高的要求．将网格技术应用于药物分子对接中,能有效解决上述问题．通过应用改进的遗传算法多种群竞争机制的对接演化模型GADock,以信息熵控制设计空间的收缩,增强了进化的有效性,显著地提高了对接效率、利用网格数据传输和网格任务调度等网格技术对分子对接过程进行了优化,有效利用了网格节点资源,并降低了药物分子的对接时间．实例测试表明了药物分子对接与网格技术相结合的合理性及有效性．     

A mixed-model approach for genome-wide association studies of correlated traits in structured populations

Genome-wide association studies (GWAS) are a standard approach for studying the genetics of natural variation. A major concern in GWAS is the need to account for the complicated dependence structure of the data, both between loci as well as between individuals. Mixed models have emerged as a general and flexible approach for correcting for population structure in GWAS. Here, we extend this linear mixed-model approach to carry out GWAS of correlated phenotypes, deriving a fully parameterized multi-trait mixed model (MTMM) that considers both the within-trait and between-trait variance components simultaneously for multiple traits. We apply this to data from a human cohort for correlated blood lipid traits from the Northern Finland Birth Cohort 1966 and show greatly increased power to detect pleiotropic loci that affect more than one blood lipid trait. We also apply this approach to an Arabidopsis thaliana data set for flowering measurements in two different locations, identifying loci whose effect depends on the environment.     

An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations

Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but they do not always account for loci of larger effect. Here we propose a multi-locus mixed model as a general method for mapping complex traits in structured populations. Simulations suggest that our method outperforms existing methods in terms of power as well as false discovery rate. We apply our method to human and Arabidopsis thaliana data, identifying new associations and evidence for allelic heterogeneity. We also show how a priori knowledge from an A. thaliana linkage mapping study can be integrated into our method using a Bayesian approach. Our implementation is computationally efficient, making the analysis of large data sets (n > 10,000) practicable.     

Research on secure buyer-seller watermarking protocol

A new buyer-seller watermarking protocol is proposed by applying a double encryption method and a novel mechanism of embedding a buyer＇s watermark. The protocol can effectively prevent against collusion attacks and the man in the middle attack if the third party is not trusted. Also, based on the proposed scheme for the first-hand transaction, a new buyer-reseller watermarking protocol and a formal multi-party watermarking protocol are also proposed. The proposed buyer-resell watermarking protocol only needs the original seller to provide transfer certificate and encryption-decryption service to support the second-hand transaction, and the multi-party watermarking protocol with distributed certificate authorities can overcome the difficulty in the combination of multicast mechanism with multiple unique watermarks and allow a seller to multicast the watermarked digital contents and key transaction information to n buyers. Furthermore, the idea of zero knowledge proof is also applied into the proposed scheme to allow the seller to take an effective control on the task performed by the third party.     

基于旋转角度的跑步运动仿真

提出基于旋转角度的方法仿真跑步运动.跑步时人体四肢和躯干都在绕关节做重复旋转运动,基于旋转角度的跑步模型根据各关节的旋转角度计算人体运动时不同部位的位置,进而求解跑步运动行为.根据该模型提出一种跑步运动仿真方法/程序,该方法可以用于跑步运动仿真和提供建模所需的人体部位的位置数据,因而可缩短建模周期.用一个慢跑仿真案例示例了该方法的仿真过程.     

企业R&D项目最佳组合及中止决策

从系统观点论述了对正在实施的 R& D项目进行中止决策的重要意义及中止决策的主要研究内容 .提出了确定企业 R& D项目最佳中止比例的三阶段数学模型 .进而 ,将该模型与模糊综合评判方法相结合来确定应被中止 R& D项目并给出一个案例.     

浅谈高校图书馆的创新服务

通过分析高等学校图书馆读者对象的需求变化,阐述了图书馆传统管理模式面临的主要问题,探讨了图书馆在服务上不断创新、不断提高、不断延伸的必要性和可行性。     

加强艺术与医学的交叉,促进艺术人才培训的科学进程——2010年全国艺术医学学术研讨会议参会感言

本文为笔者参加中国艺术医学协会第六次理事工作会议-暨全国艺术医学学术研讨会后的一些心得体会,获益匪浅。笔者将把参加会议的收获带到工作中去,为艺术学科的发展发挥应有的作用。     

CA砂浆施工技术

随着国家高速铁路建设的快速发展,无砟轨道得到了广泛应用,在博格板和底座板/水硬性支承层之间用一种特殊的沥青水泥砂浆(BZM)填充。CA砂浆是直接关系到运行寿命的关键技术。通过对现场的实践摸索和提炼,使CA砂浆在准备、封边、搅拌与灌浆效率有了显著提高,为安全质量提供了保证。     

基于f可调δ-P1近似的生物组织光学特性参数的解析

呈现一种基于可调f参数的δ-P1近似理论,结合自适应遗传算法和非线性曲线拟合,获得生物组织光学特性参数(吸收系数、散射系数和各向异性因子)的多步非线性优化算法;其中关键步骤是第一步采用自适应遗传算法精确地确定自由程,而优化用到数据来源于蒙德卡洛模拟(MC).结果表明,结合可调f参数的δ-P1近似理论,采用以自适应遗传为主的算法可以大大减少生物组织光学特性参数的估计误差.