基于Delphi的多层结构安全稳固技术的实现

传统的二层客户／服务器结构在大规模MIS应用中表现出许多局限性，为此多层结构应用体系应运而生，多层结构已成为目前分布式系统的主要应用结构。其安全稳固问题一直受业界关注。阐述了3种基于Delphi的多层结构安全稳固技术(容错技术、负载平衡技术、暂存数据技术)的原理，并给出了程序实现代码。     

基于BIM技术的室内照明仿真模拟软件计算精度解析

建筑照明专业参与BIM(building information modeling)技术的同平台作业还处于起步阶段。DIALux evo 8.2和ElumTools 2019.07是目前仅有的参与BIM技术的室内照明仿真模拟软件。采用CIE(Commission Internationale de i’Eclairage)发布的CIE 171:2006—test cases to assess the accuracy of lighting computer programs的5.2至5.8测试用例,通过验证这2款软件的计算精度,分析得出软件性能的优缺点。结果表明:在计算点光源直接照度、面光源直接照度以及光通量守恒性能这3个方面,2款软件均具有较高精度;计算大面积漫反射、遇遮挡和不同反射率这3种情况的间接照度时,DIALux evo 8.2计算精度优于ElumTools 2019.07;计算小面积漫反射的间接照度精度时,ElumTools 2019.07计算精度优于DIALux evo 8.2;计算定向透射性能时,这2款软件精度均比较低。进一步分析得出:核心算法是产生误差的主要原因,...     

Act in contravention: a non-planar coupled electrode design utilizing "tip effect" for ultra-high areal capacity,long cycle life zinc-based batteries

Aqueous zinc-based batteries (ZBBs) have great potential as commercial energy storage devices.However,the poor cycling stability of zinc anode under high areal ...     

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

Canalization, also known as developmental robustness, describes an organism's ability to produce the same phenotype despite genotypic variations and environmental influences. In Drosophila, Hsp90, the trithorax-group proteins and transposon silencing have been previously implicated in canalization. Despite this, the molecular mechanism underlying canalization remains elusive. Here using a Drosophila eye-outgrowth assay sensitized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show that the Piwi-interacting RNA (piRNA) pathway, but not the short interfering RNA or micro RNA pathway, is involved in canalization. Furthermore, we isolated a protein complex composed of Hsp90, Piwi and Hop, the Hsp70/Hsp90 organizing protein homolog, and we demonstrated the function of this complex in canalization. Our data indicate that Hsp90 and Hop regulate the piRNA pathway through Piwi to mediate canalization. Moreover, they point to epigenetic silencing of the expression of existing genetic variants and the suppression of transposon-induced new genetic variation as two major mechanisms underlying piRNA pathway-mediated canalization.     

嵌入式系统上的图形界面输入引擎的研究

嵌入式系统上的图形用户界面（GUI）由于基于不同的软硬件平台,输入设备有很大差别,所以开发者在移植时要为不同的输入设备开发其与GUI之间的接口,以使得GUI能够正确响应用户的输入。GUI的输入引擎就是介于GUI处理核心和操作系统的输入设备驱动程序之间的一组抽象接口,它的功能是使不同的输入设备的驱动程序能够无缝地连接到GUI的消息处理程序中。因此,输入引擎可以改善GUI的可移植性。在基于at91rm9200微处理器和嵌入式Linux操作系统的软硬件平台上．讨论了开发GUI输入引擎的一般方法,并结合一个具体的GUI系统——MiniGUI,给出了一个输入引擎实例的开发过程。