基于全卷积网络的左心室射血分数自动检测

提出了一种基于全卷积网络(fully convolutional networks, FCN)的左心室射血分数自动估测的方法.利用全卷积网络对心脏磁共振图像中的左心室进行内轮廓分割,计算心脏左心室在一个心动周期中各时间点的容积,提取左心室舒张末期与收缩末期的容积,最后推导出左心室的射血分数.使用700组图片对全卷积网络进行训练以及440组图片进行测试,并将最后计算结果与美国国立卫生研究院和儿童国家医疗中心提供的射血分数(ejection fraction, EF)金标准进行了对比,计算准确率为89.8%,结果处在合理的误差范围内.     

加拿大落基山脉野生动物拾零

<正>纵贯加拿大和美国的落基山脉是野生动物的王国,悠闲的黑熊,面相温和的郊狼,不怕人的大角羊,奔跑迅速的骡鹿,打洞高手哥伦比亚黄鼠,既能飞又善走的旅鸫……落基山脉自北向南纵贯加拿大和美国,延绵数千千米,在加拿大境内有4个世界遗产级的国家公园,那里有高山、森林、冰川、瀑布、河流、湖泊和温泉。十几年前我就领略过加拿大落基山脉迷人的风采,这次故地重游,又有了新的感受和体验。素食为主的美洲黑熊熊是大多数游客都害怕遇到的动物,有关"黑瞎子"伤人的传说与故事实在太多了,以至于人们谈熊色变,谁又愿意在荒山野岭与它狭路相逢呢?其实,美洲黑熊并非人们想象的那么凶残。它们     

基于改进的AHP-TOPSIS评判模型的盛大铁矿采矿方法优选

 为解决盛大铁矿低效开采的难题，运用改进的AHP-TOPSIS 综合评价指标体系模型，对5 个采矿方案进行综合评判优选。从经济、技术、安全3 方面综合考虑影响采矿方法的评判指标，通过改进的层次分析法客观地确定各评判指标的权重向量，结合逼近理想解的排序法原理，构建改进的AHP-TOPSIS 综合评判指标体系模型，基于评判指标计算出5 种采矿方案的综合优越度。结果表明，5 种采矿方案优越度依次为29%、28%、21%、22%、20%，其中分段接力退采分段充填采矿法为最优。     

Liquidity dynamics around intraday price jumps in Chinese stock market

Using 4128 single jumps detected from high frequency data of 220 individual stocks in SZ300P index, this paper investigates the liquidity dynamics around price jumps in Chinese market. Some interesting empirical results are obtained and the corresponding explanations are given. The frequency of positive jumps is quite higher than that of negative jumps. The trading volumes and average trade sizes are all in a high level around positive jumps. The relatively low liquidities around negative jumps show that negative jumps may be generated and enlarged by poor liquidity provision. The price reversal after price jumps is significant, and price reversal lasts longer after positive jumps. Moreover, the size and direction of jumps are significantly correlated with the returns and trades in the post-jump trading time. These findings are believed to be associated with the high proportion of retail investors and their herding behavior for price trend chasing.     

ATP-induced Ca<Superscript>2+</Superscript>-signalling mechanisms in the regulation of mesenchymal stem cell migration

The ability of cells to migrate to the destined tissues or lesions is crucial for physiological processes from tissue morphogenesis, homeostasis and immune responses, and also for stem cell-based regenerative medicines. Cytosolic Ca²⁺ is a primary second messenger in the control and regulation of a wide range of cell functions including cell migration. Extracellular ATP, together with the cognate receptors on the cell surface, ligand-gated ion channel P2X receptors and a subset of G-protein-coupled P2Y receptors, represents common autocrine and/or paracrine Ca²⁺ signalling mechanisms. The P2X receptor ion channels mediate extracellular Ca²⁺ influx, whereas stimulation of the P2Y receptors triggers intracellular Ca²⁺ release from the endoplasmic reticulum (ER), and activation of both type of receptors thus can elevate the cytosolic Ca²⁺ concentration ([Ca²⁺]_c), albeit with different kinetics and capacity. Reduction in the ER Ca²⁺ level following the P2Y receptor activation can further induce store-operated Ca²⁺ entry as a distinct Ca²⁺ influx pathway that contributes in ATP-induced increase in the [Ca²⁺]_c. Mesenchymal stem cells (MSC) are a group of multipotent stem cells that grow from adult tissues and hold promising applications in tissue engineering and cell-based therapies treating a great and diverse number of diseases. There is increasing evidence to show constitutive or evoked ATP release from stem cells themselves or mature cells in the close vicinity. In this review, we discuss the mechanisms for ATP release and clearance, the receptors and ion channels participating in ATP-induced Ca²⁺ signalling and the roles of such signalling mechanisms in mediating ATP-induced regulation of MSC migration.     

基于信息共享角度的团购策略研究

随着社交网络的崛起,信息共享成为消费者行为的一个重要特征. 本文基于信息共享角度,在考虑消费者特基础上对商家的团购策略进行设计. 研究表明,随着信息共享难度或低信息消费者比例的增大,团购折扣价格家利润逐渐减小,但混合团购个人购买价格却先增后减; 同时,反从众、不从众和从众消费者的比例以及从性导致的保留价值差直接影响最优的团购策略; 而较高比例的等待敏感型消费者也会导致团购折扣价格的减小. 另外,只有当高低信息消费者之间的信息差较大且信息共享难度不大时,团购策略才优于传统边际策略.     

Description of rotational properties of the superheavy nucleus ^256,258,260Rf by projected shell model

Band structure of the Z = 104 nucleus 256Rf has been a recent research focus in nuclear physics. We performed projected shell model calculations for this and some other neighboring Rf isotopes. Specifically, we studied rotational properties of these nuclei and showed that variations in dynamic moment of inertia were sensitive to single-particle structures, which may be useful information for locating the anticipated island of stability. Electromagnetic transition properties were also calculated, and measurable quantities were predicted for further experimental test.     

河北省高校区域创新体系服务调查研究

高校是区域创新体系的重要主体要素。近年来,高校凭借其雄厚的科研基础和集聚的科研人才,迅速成为推动区域经济和社会发展的主要生长点和辐射源。研究通过对河北省高校为区域创新体系发展提供人才培养培训服务、平台服务和资源保障的实际情况,总结高校服务取得的成绩和存在的问题,并提出相关发展对策和建议。     

我国扫描电镜产业的发展与预测研究

长期以来,全球电镜研发一直是美国、日本和德国三足鼎立,其中以日本日立公司、日本电子公司、美国FEI公司以及德国蔡司公司表现最为突出。而我国扫描电镜主要依靠进口,本文对韩国、日本、美国、德国等国家的产业发展经验进行研究,结合我国实际情况,分析我国扫描电镜产业的发展趋势,并提出促进我国扫描电镜产业发展的对策建议。     

一种基于不确定度的证据冲突识别方法

从高度冲突证据对D-S证据理论的应用约束出发,针对几种常用冲突度量方法存在的问题,定义了描述证据自身特征的不确定度,将证据冲突涵义从证据间不一致扩展到证据内外,给出基于不确定度的证据冲突多元度量,并为增强冲突的识别效果提出最大差异度的冲突处理方法.验证分析得出:本文给出的度量方法能够有效表征证据间的冲突程度,最大冲突差异度的处理实现了证据冲突识别的显著化,在证据冲突度量与识别中具有很好的普适性和有效性.