带形状参数的有理曲面构造

带形状参数的有理样条曲线在插值条件确定的情况下可以灵活地约束曲线的形状.基于有理三次曲线,构造了带形状参数的有理混合函数,进而构造了一种带形状参数的有理曲面片.所构造的有理曲面片不仅具有双三次Coons曲面片的良好性质,而且带有自由参数,在边界条件固定的情况下,可通过调控自由参数实现曲面片内部形状的控制.     

聚氨基环三磷腈的制备及性能分析

对氨基环三磷腈的缩聚及缩聚物的性能进行了研究.结果表明,氨基环三磷腈的取代度对其缩聚有显著的影响.随取代度的增大,聚合产率先增大后减小,游离氯、结合氯含量均逐渐减少,而溶解度、吸湿性逐渐增大.氨基环三磷腈的较佳缩聚条件是：氨基环三磷腈的取代度为92.6％,聚合温度为178～182℃,聚合时间为0.5h.在此条件下,产品的产率为94.32％,总氯含量为2.05％,磷含量为50.89％,氮含量为43.38％,氢含量为3.68％,溶解度为1.05 g（100mL水中）,在相对湿度为50％～60％时,吸湿率为5.9％.聚氨基环三磷腈主要由氨基环三磷腈的二聚体、三聚体、四聚体和五聚体组成,其中以三聚体为主.聚氨基环三磷腈阻燃元素磷、氮含量高,热稳定性较好,近于中性,适合作为阻燃剂.     

社交网络环境下社区发现的文献计量研究--基于Web of Science

基于Web of Science中检索得到的文献数据,使用CiteSpace、SATI、UCINET等软件构建科学知识图谱,从国家及机构、关键文献、关键词及突现词等角度对社交网络环境下有关社区发现的研究现状、研究热点和研究前沿进行了文献计量分析。     

浅谈厦门市图书馆电子阅览室的读者服务工作

阐述了厦门市图书馆电子阅览服务的现状,探讨了厦门市图书馆电子阅览服务存在的不足之处,提出了改进厦门市图书馆电子阅览服务的建议,包括为青少年读者提供特定阅览服务、合理规划网络布局满足读者需求等。     

提高高校电子阅览室信息服务质量的策略

对比分析了高校的阅读方式,提出了提高手机阅读信息服务质量的策略。     

复杂矿山设备周期激励响应分析的增量谐波平衡法

针对复杂矿山设备中由于存在周期激励而引发的严重振动问题,以大型矿用给料装置为研究对象,将其钢结构机架简化为框架结构模型;考虑物料冲击是引发振动的主要原因,推导了非简谐周期激励的增量谐波平衡法;采用此方法分析周期激励下矿山设备的振动特性,并与Newmark-β法进行对比,验证了算法的精确性效率;研究设备与地面或基础接触时产生的非线性动响应,以及不同地面软硬程度下响应的规律.结果表明,该法用来分析复杂矿山设备在周期激励作用下的非线性稳态响应问题是有效的.     

Scalable manufacturing methodologies for improving adeno-associated virus-based pharmaprojects

Adeno-associated virus （AAV） is a promising viral vector and meets most requirements of being a safe biological agent. However, the commercialization of AAV has been hampered due to the limitation of large-scale production, and only a small number of clinical trials have been launched. In recent years, progresses in scalable manufacturing of AAV have dramatically improved AAV- based clinical researches, and have assisted the develop- ment of investigational drug products. An AAVl-based investigational product, Glybera, has been formally approved by European Commission for the treatment of lipoprotein lipase deficiency （LPLD）. Glybera was the first gene therapy product in the western world, and the pro- duction process involves a scalable baculovirus-insect cell system. However, many problems still need to be solved to improve the productivity and quality of AAV. The present review gives critical insights into current state-of-the-art scalable producing methodologies of AAV, such as bacu-lovirus-insect cell system, HSV complementation system, and Ad complementation system, along with a discussion on the problems, solutions, and developmental trends.Novel AAV-producing platforms in Saccharomyces cere- visiae and vaccinia virus complementation system will also be discussed.     

大黄鱼消化系统的组织学和组织化学研究

为探讨大黄鱼消化系统的结构与功能,用组织学和组织化学方法对各主要消化器官进行了研究.胃前段粘膜上皮由柱状细胞和粘液细胞组成;胃中后段粘膜上皮仅有柱状细胞,固有层含有发达的胃腺,胃腺上皮由Ⅰ型和Ⅱ型细胞构成.幽门盲囊与肠粘膜形成发达的皱襞和绒毛,粘膜上皮由柱状细胞和粘液细胞组成.胰腺为弥散性腺体.胃中后段粘膜柱状细胞呈现脂酶和非特异性酯酶活性;胃前段粘膜粘液细胞及胃腺Ⅰ型细胞分泌中性和酸性混合粘液,胃腺Ⅱ型细胞呈现强蛋白酶活性.幽门盲囊与肠粘膜粘液细胞分泌酸性粘液,柱状细胞呈现蛋白酶、脂酶和非特异性酯酶活性,其游离端质膜和胞质还分别具有碱性磷酸酶和酸性磷酸酶活性.肝细胞和胰腺细胞呈现非特异性酯酶和弱蛋白酶活性,肝细胞还贮存糖原.     

Properties and Morphology of TiN Films Deposited by Atomic Layer Deposition

In this study,TiN films were deposited on SiO2 substrates by Atomic Layer Deposition(ALD) using TiCl4and NH3 as precursors. Properties and morphology of the TiN films were characterized by different methods.Using Grazing Incidence X-Ray Diffraction(GIXRD),TiN films demonstrated polycrystalline structure with(111)preferred orientation. Film thickness was measured by Spectroscopic Ellipsometry(SE) and a stable growth rate of 0.0178 nm/cycle was reached after 500 deposition cycles,which was consistent with the essence of ALD as a surface-saturated self-limiting reaction. Film resistivity measured by a four-point probe continuously decreased with increasing deposition cycles until it reached the minimum value of 300μΩ cm at 5000 deposition cycles with a thickness of 87.04 nm. The surface roughness and morphology of the TiN films at different deposition cycles ranging from 50 to 400 were analyzed by Atomic Force Microscopy(AFM). The AFM results indicated that the initial film growth follows the Stranski-Krastanov mode.     

地方高校中外合作办学本科项目教学机制研究——以湖北工程学院为例

在我国高等教育体系中,中外合作办学有了较快的发展,一些地方高校都进行了中外合作办学的实践。以湖北工程学院为例,地方高校中外合作办学本科项目的现状及问题是:地方高校中外合作办学有重视外语教学和利用外方教学资源与教学理念的优势,存在着语言课程与专业课程融合不够,中外双方缺乏深度合作等问题。地方高校应当在中外合作办学本科项目的人才培养机制、教学管理机制、资源配置机制、教学质量保障机制等方面加以改进,以最大限度地发挥中外合作教育的独特功效。