苯甲酰类化合物构效关系的模式识别研究

用ＣＮＤＯ／２量化方法计算了３５个苯甲酰类化合物的量化指数,并应用模式识别方法研究了该类化合物的结构对治疗患Ｌ１２１０肿瘤小鼠药效的影响,得到满意的分类图。结果表明化合物的抗癌活性的主要影响因素为ＣＱＳ、ＥＬＵＭＯ、ＥＳＨＥＰ和π,药物的抗癌活性主要是通过抑制核苷酸还原酶所致,而且化合物在体内到达受体的过程和难易程度对药效的影响较大。     

试论目前高速公路排水设计的不合理性

通过对高速公路边沟、中央分隔带、桥梁泄水孔的排水能力的计算与分析,结合南京新机场高速公路建设过程中的工程实例,初步论证目前高速公路排水设计的不合理性,提出了一些有价值的建议,对今后高速公路的设计与施工具有指导作用．     

一种基于空间域和频谱域特征的图象分割方法

提出了一种基于空间域和频谱域特征的神经网络的医学图像分割方法．本方法不需要教师监督,能自动生成最优的网络输出节点,即分类数．对ＣＴ,ＭＲＩ和超声图像的分割表明本方法有效方便．     

车间作业计划的模糊多目标网络方法

讨论了模糊集理论在车间作业计划中的应用,提出了车间作业计划的模糊多目标网络模型及其算法。     

The discovery of early Permian reef belt in east Kunlun and its significance

The early permian reef belt is distributed in the southern side of eastern Kunlun, north area of Qinghai-Tibet Plateau. The core-reef facies of thc reel extends from Tuosuo Lake to Huashixia. Lots of reef breccia was found at the southern slope of the mre-reef belt, and to the north of the reef belt there is back-reef limestone. Cacisponges, hydrozoa, bryozoa,Tabulozoa, Tubiphytes and red algae are the main frame-building organisms.Archaeolithoporella, laminated blue-green algaes,Tabulozoa andTubiphytes played a role of binding or encrustating. There are many kinds of epibiont in the mf, including brachiopod, gasterid, foraminifera, echinoderm and simple coral. The type and the characteristics of the reef-building organisms in eastern Kunlun and Animaqing are basically thr same as those in the south of Chi     

Signal transduction pathways mediated by colony stimulating factor-1 receptor

Colony-stimulating factor-1 (CSF-1), which is necessary for cell proliferation and differentiation, regulates both immediate and delayed early responses throughout G1 phase. The binding of CSF-1 to its receptor (CSF-1R) triggers phosphorylation of the receptor and its intrinsic tyrosine kinase. The activated receptor binds directly to cytoplasmic effector proteins, which induce multiple-signal transduction pathways. CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins. The expression of c-fos/jun family genes is also targeted following the activation of Ras. CSF-1R activates STAT1 and STAT3 to participate in signaling, but JAKs do not appear to contribute to signaling by CSF-1R. CSF-1R activates PI3-kinase, and PI3-ki can interact with downstream proteins by the MAPKK-related pathway independent of Ras/Raf. PC-PLC can enforce signaling in response to CSF-1. Furthermore, the turnover and dephosphorylation by the phosphatase SHPTP1 of CSF-1R are the major mechanism in the negative regulation of signaling by CSF-1R     

机器人多指协调操作中抓取力的实时控制

提出了一个通用的抓取力实时控制算法．推广了抓取力的定义,探讨了抓取力存在性．定义了最优抓取力,给出了计算最优抓取力的具体算法．其核心是把抓取力的大小与方向分开处理,在抓取规划阶段确定抓取力的方向,在任务操作时仅调整抓取力的大小,而方向保持不变．该算法能很好地满足协调操作中力控制的实时性要求．仿真结果显示了其优越性．     

Search for new antiphytovirucides

The lead compound of substituted 2-(4′-hydroxyphenyl)benzimidazoles were modified by phosphorylation sulfonation and carboxymethylation. The benzimidazoloamidophosphate (6) (7) have better activity against tobacco mosaic virus (TMV). The benzimidazolophenoxyacetic acid, phenoxysulfonic acid containing trifluoromethyl, and nitro group have 77%≈85% efficiency for wheat rust disease. Supported by the National Natural Science Foundation of China and National Laboratory of Elemento Organic Chemistry Nankai University Qu Fanqi: born in 1952, Associate professor     

相似设计方法在微小移动机器人性能分析中的应用

将微小移动机器人放大后,作模型试验,利用相似理论,进行模型的设计,并把模型的试验结果应用到原型上去。     

连续驱动摩擦焊负载等效电气特性的研究

通过对连续驱动摩擦焊能量参数的计算机实时、同步检测,经过计算发现：摩擦焊负载的电气特性并不是纯电阻特性（耗能特性）,而是表现出阻容双重特性（耗能和储能特性）．经理论分析认为,负载的电容特性（储能特性）是由于工件在摩擦扭矩的作用下,产生弹性扭转变形并储存了主电机供给的机械能所造成．研究结果有利于方便实现连续驱动摩擦焊过程的数值模拟,为深入研究连续驱动摩擦焊过程的本质打下了坚实的基础．