Induction of human β-defensin-2 in airway epithelial cells by Streptococcus pneumoniae:involvement of IP3-dependent intracellular calcium release and NF-jB

Human β-definsin-2(hBD-2)is mainly induced by bacterial factors and pro-inflammation mediators in epithelial cells.As the major cause of community-acquired pneumonia,whether Streptococcus pneumoniae(S.pneumoniae)stimulation induces hBD-2 expression in airway epithelial cells is elusive.In this study,we found that S.pneumoniae stimulation induced hBD-2 expression in a time-and concentration-dependent manner in primary human airway epithelial cells.To further reveal the mechanism of S.pneumoniae inducing hBD-2,we found that S.pneumoniae stimulation activated NF-jB signaling pathway.Specific NF-jB inhibitor,PDTC,could reverse the induction of hBD-2 by S.pneumoniae.We also found that cellular inner Ca2+ signaling is involved in the S.pneumoniae-induced hBD-2.Taken together,our findings indicated that S.pneumoniae can stimulate the expression of hBD-2 in airway epithelial cells and NF-jB and inositol triphosphate-dependent intracellular calcium release is involved in this induction.     

A new implementation of image-processing engine for 3D visualization and stereo video stream display

This paper presents a new implementation of a high-definition image-processing engine,which mainly targets the 3-dimensional(3D)visualization and stereo video stream display of binocular display equipment.The engine is compatible with the mainstream analog and digital stereo videos in component format and is able to receive stereo composite video broadcast signals using an integrated analog stereo video decoder.The four modules include a spatiotemporal scaling transform engine,a 2D–3D converter,an image animating engine,and a 2D scalar operating in pipeline architecture to implement the video format conversion and the stereo effect enhancement.Furthermore,the data access,hardware structure,and system-level configurations are optimized.Finally,the proposed architecture is realized by 0.18 lm CMOS technology.The application-specific integrated circuit verification results show that the engine can generate a strong feeling of 3D immersion and highdefinition image quality with minimal flicker.The chip has wide compatibility and an uppermost 1080P-processing capacity,which has approximately 3.5 million gates with about 43 mm2 die size.     

Review： Deregulation of microRNA expression in thyroid tumors

MicroRNAs （miRNAs or miRs） are endogenous non-coding RNAs that negatively regulate gene expres- sion by binding to the 3＇ non-coding regions of target mRNAs, resulting in their cleavage or blocking their translation. miRNAs may have an impact on cell differentiation, proliferation, and survival, and their deregulation can be inclined to diseases and cancers, including thyroid tumors. The purpose of this review is to summarize the existing findings of deregulated miRNAs in different types of thyroid tumors and to exhibit their potential target genes, especially to demonstrate those involved in tumor invasion and metastasis. In addition, new findings of circulating miRNA expres- sion profiles, single nucleotide polymorphism （SNP） in thyroid tumors, and the correlation of somatic mutations with deregulated miRNA expression in thyroid tumors were all included in this review.     

基本上成立的概念及其应用

主要讨论了基本上成立的一些概念,并给出与这些概念相关的一些性质,同时用基本上成立的概念简述一些定理和性质的叙述、证明及它们之间的关系.     

PBNA： An Improved Probabilistic Biological Network Alignment Method

Biological network alignment is an important research topic in the field of bioinformatics. Nowadays almost every existing alignment method is designed to solve the deterministic biological network alignment problem.However, it is worth noting that interactions in biological networks, like many other processes in the biological realm,are probabilistic events. Therefore, more accurate and better results can be obtained if biological networks are characterized by probabilistic graphs. This probabilistic information, however, increases difficulties in analyzing networks and only few methods can handle the probabilistic information. Therefore, in this paper, an improved Probabilistic Biological Network Alignment（PBNA） is proposed. Based on Iso Rank, PBNA is able to use the probabilistic information. Furthermore, PBNA takes advantages of Contributor and Probability Generating Function（PGF） to improve the accuracy of node similarity value and reduce the computational complexity of random variables in similarity matrix. Experimental results on dataset of the Protein-Protein Interaction（PPI） networks provided by Todor demonstrate that PBNA can produce some alignment results that ignored by the deterministic methods, and produce more biologically meaningful alignment results than Iso Rank does in most of the cases based on the Gene Ontology Consistency（GOC） measure. Compared with Prob method, which is designed exactly to solve the probabilistic alignment problem, PBNA can obtain more biologically meaningful mappings in less time.     

一种新的获取Zigbee网络拓扑信息方法

以TI公司CC2530模块为例,根据Zigbee路由协议,在总结现有路由算法的基础上,给出了一种新的获取Zigbee网络拓扑信息的方法 .仿真结果表明,系统自动获取的网络拓扑信息与Zigbee无线网络中的理论地址分配机制是一致的,为Zigbee网络的有效、安全管理提供了一种可靠的手段.     

An investigation on terahertz response in electro-optic crystals excited at 1.03 lm wavelength

We theoretically investigate terahertz(THz)emission and detection from h110i-oriented electro-optic(EO) crystals adapted for Yb-doped femtosecond pulse laser.According to the principles of phase-matching condition, the dispersion relation between optical velocity and THz pulse,THz absorption spectra, and coherence lengths of CdTe, GaP,and GaAs crystals below the phonon resonant frequency are calculated correspondingly. The optical rectification and EO sampling process of above crystals with the same thickness of0.1 mm are simulated. As a consequence, we found that the optimal emission frequency of CdTe is at 2.65 THz, however,it reaches 6.56 THz of GaAs and 4.77 THz of GaP. With the help of frequency response function, the calculated cut-off frequency of CdTe is only 3.45 THz, while GaAs and GaP achieve 7.15 and 6.37 THz correspondingly. Finally, the EO sampling sensitivity of GaAs is higher than CdTe and GaP when the crystal's thickness exceeds 1.58 mm. The strong THz absorption of CdTe saturates distinctly the EO sampling sensitivity with its thickness increasing.     

Grey hematite photoanodes decrease the onset potential in photoelectrochemical water oxidation

Photoelectrochemical (PEC) water splitting for solar energy conversion into chemical fuels has attracted intense research attention.The semiconductor hematite (...     

高铬铸铁的热处理与二次硬化

利用扫描电镜分析和机械性能测试对15-2-1型高铬铸铁的二次硬化效应进行了研究,并结合合金耐磨性分析探讨了二次硬化效应在高铬铸铁锚喷衬板中的作用.     

用中性溶液法制备硅基太阳能电池用低反射涂层

用中性溶液法在硼硅酸盐玻璃片上制备了低反射涂层,并在Na2HPO4和AlCl3组成的浸涂液中于95℃条件下恒温浸泡6 h,结果表明硼硅酸盐玻璃片在400～900 nm波长内的平均透过率由原来的91.97%提高至98.97%,平均反射率降低至1.41%.中心波长处反射率仅为0.85%.为提高涂膜的耐候性,以低质量分数的十...