The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

基于变量选择-神经网络模型的复杂路网短时交通流预测

摘要： 针对传统交通流预测模型正在由单断面历史数据处理向多断面、多时刻历史数据处理转变,但在考虑各断面间的影响时,多变的交通状况往往会使预测模型复杂化的问题,引入一种多元线性回归最小绝对收缩和选择算子方法(Lasso),并利用其优秀的变量选择能力,在复杂路网多断面中选出相关性较高的断面；结合神经网络(NN)的非线性特性,提出了Lasso NN组合模型.结果表明：Lasso NN模型在路网交叉口对未来15 min交通流数据预测的误差率低于9.2%；在非交叉口的误差率低于6.7%,总体优于各自单独使用得出的结果.     

Reconsideration on Homogeneous Quadratic Riemann Boundary Value Problem

The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained.     

发挥政府主导作用 推进科技评估管理

介绍了中国科技评估的发展状况、内容、法规建设，论述了政府在科技评估管理中的作用。     

Abrupt climate change：Debate or action

Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere.     

The Optimal Solution of the Model with Physical and Human Capital Adjustment Costs

We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small.     

智能小区网络的系统设计

介绍了智能住宅与智能小区的概念，并针对其特点提出了智能小区网络的设计方案，着重介绍了楼宇自动化网络系统，园区一卡通网络系统。     

新型流量传感器在呼吸机上的应用

介绍了AWM720P1新型气体流量传感器的工作原理、性能、特点．针对呼吸机的工作特点，分析了IPPV的流速模型、流速的测量方法、传感器的校正数据处理方法．     

任职经济责任审计系统设计与实现

该系统严格遵照国家干部经济责任审计的有关准则与规定，能够对企事业单位、行政单位等不同部门各个层次的领导干部，从内控制度、管理、经营、财务等多方面、多角度、全方位地进行跟踪审计，客观公正、实事求是地对有关报表数据进行科学分析，恰如其分地认定干部实绩和经济责任。     

内燃机燃烧过程仿真后处理输入文件Ipost的研究

以系统论为理论依据，在计算机上进行试验和分析，研究了输入件的设计要求和方法。研究表明：后处理输入件要设计后处理硬件类型、图形件(*．ps)的输出模式和镜像输出条件等总则，要确定输出内容包括网格划分和性能计算结果两个大的方面，网格划分的输出可以按平面图和三维图两种类型输出。性能等高线图和矢量图可以按正平面图和斜平面图的类型输出，网格图和性能图均按仿真计算的曲轴转角(时间)输出。