全文获取类型
收费全文 | 2614篇 |
免费 | 9篇 |
国内免费 | 25篇 |
专业分类
系统科学 | 44篇 |
丛书文集 | 2篇 |
教育与普及 | 11篇 |
理论与方法论 | 41篇 |
现状及发展 | 291篇 |
研究方法 | 363篇 |
综合类 | 1797篇 |
自然研究 | 99篇 |
出版年
2022年 | 4篇 |
2021年 | 9篇 |
2020年 | 4篇 |
2019年 | 6篇 |
2018年 | 25篇 |
2017年 | 16篇 |
2016年 | 29篇 |
2015年 | 22篇 |
2014年 | 22篇 |
2013年 | 44篇 |
2012年 | 205篇 |
2011年 | 352篇 |
2010年 | 73篇 |
2009年 | 10篇 |
2008年 | 222篇 |
2007年 | 231篇 |
2006年 | 222篇 |
2005年 | 251篇 |
2004年 | 253篇 |
2003年 | 187篇 |
2002年 | 242篇 |
2001年 | 6篇 |
2000年 | 16篇 |
1999年 | 11篇 |
1998年 | 6篇 |
1997年 | 7篇 |
1996年 | 9篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 6篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 9篇 |
1982年 | 10篇 |
1981年 | 10篇 |
1980年 | 4篇 |
1979年 | 14篇 |
1978年 | 10篇 |
1977年 | 8篇 |
1974年 | 5篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1971年 | 6篇 |
1970年 | 7篇 |
1967年 | 5篇 |
排序方式: 共有2648条查询结果,搜索用时 62 毫秒
681.
682.
Drying-mediated self-assembly of nanoparticles 总被引:1,自引:0,他引:1
Systems far from equilibrium can exhibit complex transitory structures, even when equilibrium fluctuations are mundane. A dramatic example of this phenomenon has recently been demonstrated for thin-film solutions of passivated nanocrystals during the irreversible evaporation of the solvent. The relatively weak attractions between nanocrystals, which are efficiently screened in solution, become manifest as the solvent evaporates, initiating assembly of intricate, slowly evolving structures. Although certain aspects of this aggregation process can be explained using thermodynamic arguments alone, it is in principle a non-equilibrium process. A representation of this process as arising from the phase separation between a dense nanocrystal 'liquid' and dilute nanocrystal 'vapour' captures some of the behaviour observed in experiments, but neglects entirely the role of solvent fluctuations, which can be considerable on the nanometre length scale. Here we present a coarse-grained model of nanoparticle self-assembly that explicitly includes the dynamics of the evaporating solvent. Simulations using this model not only account for all observed spatial and temporal patterns, but also predict network structures that have yet to be explored. Two distinct mechanisms of ordering emerge, corresponding to the homogeneous and heterogeneous limits of evaporation dynamics. Our calculations show how different choices of solvent, nanoparticle size (and identity) and thermodynamic state give rise to the various morphologies of the final structures. The resulting guide for designing statistically patterned arrays of nanoparticles suggests the possibility of fabricating spontaneously organized nanoscale devices. 相似文献
683.
684.
685.
686.
The vector alignments of asteroid spins by thermal torques 总被引:1,自引:0,他引:1
Collisions have been thought to be the dominant process altering asteroid rotations, but recent observations of the Koronis family of asteroids suggest that this may be incorrect. This group of asteroids was formed in a catastrophic collision several billion years ago; in the intervening period their rotational axes should have become nearly random because of subsequent collisions, with spin rates that follow a maxwellian distribution. What is seen, however, is that the observed family members with prograde spins have nearly identical periods (7.5-9.5 h) and obliquities between 42 and 50 degrees, while those with retrograde spins have obliquities between 154 and 169 degrees with periods either <5 h or >13 h. Here we show that these non-random orientations and spin rates can be explained by 'thermal torques' (arising from differential solar heating), which modify the spin states over time. In some cases, the asteroids become trapped in spin-orbit resonances. Our results suggest that thermal torques may be more important than collisions in changing the spin states (and possibly shapes) of asteroids with diameters <40 km. 相似文献
687.
Dumoulin M Last AM Desmyter A Decanniere K Canet D Larsson G Spencer A Archer DB Sasse J Muyldermans S Wyns L Redfield C Matagne A Robinson CV Dobson CM 《Nature》2003,424(6950):783-788
Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues, often with serious pathological consequences. Non-neuropathic systemic amyloidosis is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody raised against wild-type human lysozyme inhibits the in vitro aggregation of its amyloidogenic variant, D67H. Our structural studies reveal that the epitope includes neither the site of mutation nor most residues in the region of the protein structure that is destabilized by the mutation. Instead, the binding of the antibody fragment achieves its effect by restoring the structural cooperativity characteristic of the wild-type protein. This appears to occur at least in part through the transmission of long-range conformational effects to the interface between the two structural domains of the protein. Thus, reducing the ability of an amyloidogenic protein to form partly unfolded species can be an effective method of preventing its aggregation, suggesting approaches to the rational design of therapeutic agents directed against protein deposition diseases. 相似文献
688.
Howitz KT Bitterman KJ Cohen HY Lamming DW Lavu S Wood JG Zipkin RE Chung P Kisielewski A Zhang LL Scherer B Sinclair DA 《Nature》2003,425(6954):191-196
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD(+)-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53 tumour suppressor. Here we report the discovery of three classes of small molecules that activate sirtuins. We show that the potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD(+), and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan by 70%. We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators. 相似文献
689.
Cyranoski D 《Nature》2003,425(6954):113
690.