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71.
Dopaminergic neurons in the mammalian brain have received substantial attention in the past given their fundamental role in
several body functions and behaviours. The largest dopaminergic population is found in two nuclei of the ventral midbrain.
Cells of the substantia nigra pars compacta are involved in the control of voluntary movements and postural reflexes, and
their degeneration in the adult brain leads to Parkinson’s disease. Cells of the ventral tegmental area modulate rewarding
and cognitive behaviours, and their dysfunction is involved in the pathogenesis of addictive disorders and schizophrenia.
Because of their clinical relevance, the embryonic development and maintenance of the midbrain dopaminergic cell groups in
the adult have been intensively studied in recent years. In the present review, we provide an overview of the mechanisms and
factors involved in the development of dopaminergic neurons in the mammalian brain, with a special emphasis on the midbrain
dopaminergic population.
Received 17 August 2005; received after revision 28 September 2005; accepted 21 October 2005 相似文献
72.
Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Oxidative stress is most often defined as an imbalance between the generation of reactive oxygen species (ROS) in excess of the capacity of cells/tissues to detoxify or scavenge them. Additionally, the regulated production of ROS participates in cellular signaling. Therapeutic strategies to treat IPF have, thus far, focused on augmenting anti-oxidant capacity. Recent studies have demonstrated a critical role for ROS-generating enzymatic systems, specifically, NADPH oxidase (NOX) family oxidoreductases in fibrotic processes. In this review, we examine the evidence for NOX isoforms in the generation and perpetuation of fibrosis, and the potential to target this gene family for the treatment of IPF and related fibrotic disorders. 相似文献
73.
TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome 总被引:1,自引:0,他引:1
C Boileau DC Guo N Hanna ES Regalado D Detaint L Gong M Varret SK Prakash AH Li H d'Indy AC Braverman B Grandchamp CS Kwartler L Gouya RL Santos-Cortez M Abifadel SM Leal C Muti J Shendure MS Gross MJ Rieder A Vahanian DA Nickerson JB Michel;National Heart Lung Blood Institute 《Nature genetics》2012,44(8):916-921
A predisposition for thoracic aortic aneurysms leading to acute aortic dissections can be inherited in families in an autosomal dominant manner. Genome-wide linkage analysis of two large unrelated families with thoracic aortic disease followed by whole-exome sequencing of affected relatives identified causative mutations in TGFB2. These mutations-a frameshift mutation in exon 6 and a nonsense mutation in exon 4-segregated with disease with a combined logarithm of odds (LOD) score of 7.7. Sanger sequencing of 276 probands from families with inherited thoracic aortic disease identified 2 additional TGFB2 mutations. TGFB2 encodes transforming growth factor (TGF)-β2, and the mutations are predicted to cause haploinsufficiency for TGFB2; however, aortic tissue from cases paradoxically shows increased TGF-β2 expression and immunostaining. Thus, haploinsufficiency for TGFB2 predisposes to thoracic aortic disease, suggesting that the initial pathway driving disease is decreased cellular TGF-β2 levels leading to a secondary increase in TGF-β2 production in the diseased aorta. 相似文献
74.
75.
Åsa Fex Svenningsen Svenja Löring Anna Lahn Sørensen Ha Uyen Buu Huynh Simone Hjæresen Nellie Martin Jesper Bonnet Moeller Maria Louise Elkjær Uffe Holmskov Zsolt Illes Malin Andersson Solveig Beck Nielsen Eirikur Benedikz 《Cellular and molecular life sciences : CMLS》2017,74(24):4561-4572
Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is implicated in some of the same diseases as MIF. We show that the function of the binding between MIF and HTRA1 is to inhibit the proteolytic activity of HTRA1, modulating the availability of molecules that can change cell growth and differentiation. MIF is therefore the first endogenous inhibitor ever found for HTRA1. It was found that both molecules were present in astrocytes and that the functional binding has the ability to modulate astrocytic activities important in development and disease of the CNS. 相似文献
76.
77.
Diamine oxidase present in the cotyledons of germinating pea seeds is induced by phytic acid but the embryo enzyme is not affected. Polyamines have no effect on phytase activity of the cotyledon or embryo. 相似文献
78.
Systemic Practice and Action Research - This paper gives a detailed account of the activities I engaged in when establishing a co-operative inquiry (CI) group of 12 young women managers. I feel... 相似文献
79.
T. S. S. Dikshith Prakash Chandra K. K. Datta 《Cellular and molecular life sciences : CMLS》1973,29(6):684-685
Zusammenfassung Langfristig wiederholte Lindan-Applikation ruft bei der Abinoratte histopathologische hautveränderungen hervor: Hyperkeratinisation, intraepidermale und dermale Abszesse, Infiltration polymorphkerniger Zellen sowie Vakuolisation und Vielkernigkeit in der Malpighi-Schicht.
Pury -isomer of 1,2,3,4,5,6-hexachlorocyclohexane. 相似文献
Pury -isomer of 1,2,3,4,5,6-hexachlorocyclohexane. 相似文献
80.
DNA lesions can often block DNA replication, so cells possess specialized low-fidelity, and often error-prone, DNA polymerases that can bypass such lesions and promote replication of damaged DNA. The Saccharomyces cerevisiae RAD30 and human hRAD30A encode Pol eta, which bypasses a cis-syn thymine-thymine dimer efficiently and accurately. Here we show that a related human gene, hRAD30B, encodes the DNA polymerase Pol iota, which misincorporates deoxynucleotides at a high rate. To bypass damage, Pol iota specifically incorporates deoxynucleotides opposite highly distorting or non-instructional DNA lesions. This action is combined with that of DNA polymerase Pol zeta, which is essential for damage-induced mutagenesis, to complete the lesion bypass. Pol zeta is very inefficient in inserting deoxynucleotides opposite DNA lesions, but readily extends from such deoxynucleotides once they have been inserted. Thus, in a new model for mutagenic bypass of DNA lesions in eukaryotes, the two DNA polymerases act sequentially: Pol iota incorporates deoxynucleotides opposite DNA lesions, and Pol zeta functions as a mispair extender. 相似文献