Study of transmembrane La3+ movement in rat ventricular myocytes by the patch-clamp technique

We have studied transmembrane La3+ movement in rat ventricular myocytes for the first time by using the whole-cell patch-clamp recording mode. La3+ (0.01-5.0 mmol/L) could not bring out inward currents through the L-type calcium channel in rat ventricular myocytes, while it could enter the cells by the same way carried by 1μmol/L ionomycin. When the outward Na+ concentration gradient is formed, La3+ can enter the cells via Na-Ca exchange, and the exchange currentsincrease with the increase of external La3+ concentrations. But compared with Na-Ca exchange currents in the same concentration, the former is only 14%-38% of the latter. The patch-clamp experiment indicates that La3+ normally can not enter ventricular myocytes through L-type calcium channel, but it can enter the cells via Na-Ca exchange.     

中国工商银行分辖联行往来逐笔对帐计算机处理系统的设计与实现

实行分辖联行逐笔对帐是联行对帐工作的一次重大改革,该系统的主要功能是为分辖联行逐笔对帐业务提供完善和连续的支持,加速资金周转,杜绝犯罪,促进社会和经济的发展.本文分析了系统涉及的数据及数据流向;阐述了系统总体设计思想;重点讨论了帐务正确和完备性制约体系、三级安全保密体系及最佳逐笔核对算法的设计,为银行业务系统设计提供借鉴作用.     

人参多肽最低构象能计算分析

本文采用黄金分割法优化初始构象,运行ECEPP/2程序计算得到人参十四肽最低构象能为467.582KJ/mol;根据计算的原子坐标绘制的分子结构图表明最低构象能下的人参十四肽构象由β—折叠肽段及α—螺旋肽段构成.     

液体动力润滑滑动轴承概率设计

为了最大限度地满足液体动力润滑径向滑动轴承的承载量系数值,以达到滑动轴承承载能力的要求,提出液体动力润滑径向滑动轴承概率设计的数学模型,并给出了具体的概率设计方法.实例计算结果表明,该方法实用、合理.     

我校护理学专业学生维生素A营养水平评价

目的：了解护理学专业大学生维生素A营养水平.方法：采用YA-Ⅱ型暗适应计测185名学生暗适应时间.结果：维生素A不足者28人,占15.1%,未发现夜盲症.结论：大多数学生维生素A营养状况正常,但少数学生维生素A不足,应注意调整膳食结构,增加富含维生素A食物的摄入.     

驻波法测量空气中声速实验的探讨

针对驻波法测量空气声速实验中存在的问题,通过理论推导,探讨了声波位移波动方程和声压波动方程之间的关系,使学生对超声波声场有了较为深刻的认识.     

RGIS(矿山资源地理信息系统)在数字矿山中的应用

简要地分析了我国煤矿生产中矿图绘制所需的各类软件的利弊,针对煤炭专业业务处理的具体特点,系统地概括了RGIS在煤矿生产中的应用,通过实例分析,阐述了RGIS在矿山地质测量中的应用效果。     

Glutamate stimulates inositol phosphate formation in striatal neurones

The major excitatory amino acids, glutamate (Glu) and aspartate (Asp), are thought to act at three receptor subtypes in the mammalian central nervous system (CNS). These are termed quisqualate (QA), N-methyl-D-aspartate (NMDA) and kainate (KA) receptors according to the specific agonist properties of these compounds revealed by electrophysiological studies. Although Glu has been shown to stimulate cyclic GMP formation in brain slices, direct regulation of second messenger systems (cyclic AMP, Ca2+ or inositol phosphates) subsequent to activation of excitatory amino-acid receptors, has not been extensively studied. Here we demonstrate that in striatal neurones, excitatory amino acids, but not inhibitory or non-neuroactive amino acids, induce a three- to fourfold increase in inositol mono-, di- and triphosphate (IP, IP, IP) formation with the relative potency QA greater than Glu greater than NMDA, KA. The Glu-evoked formation of inositol phosphates appears to result principally from actions at QA as well as NMDA receptors on striatal neurones. Our results suggest that excitatory amino acids stimulate inositol phosphate formation directly, rather than indirectly by the evoked release and subsequent actions of adenosine or acetylcholine.     

一个面向对象的需求规格说明语言——SEURSL

提出了一种从建模到实现的完整的面向对象开放方法，它以Ｃｏａｄ／Ｙｏｕｒｄｏｎ方法为基础并对它进行了改进，改进后的方法能够有效地描述系统的功能和行为；同时给出了支持这种方法的需求规格说明语言———ＳＥＵＲＳＬ的规范化定义。     

基于学习设计规范的SLeD播放平台国际化应用

依据Struts框架理论用系统设计的方法对SLeD播放平台实施国际化应用开发,实现了SLeD播放平台的国际化应用,使其自动适应学习者本地语言环境,消除了语言障碍,为更好地推广应用学习设计提供了平台支持.同时,本方法也为其他网络应用系统的国际化应用提供借鉴和参考.