基于组态软件的变电所微机监控系统

为解决目前中小变电所监控系统实时性差、误差大，不利于联网调度的缺点和不足，文提出一种在组态软件开发平台下的实时数据采集及调度自动化系统。利用工控机、智能模块，485总线及设备构成硬件系统，应用公共电话交换网实现变电所与远方调度的互联，利用工业组态软件开发软件控制系统，设计并实现了变电所微机监控集散控制系统功能。     

基于数据分组处理方法的聚类分析模型

与通常的聚类方法相比,客观聚类分析方法能自动、客观地确定聚类个数并找到最优聚类方案.通过算法步骤的剖析和算例分析,对客观聚类分析方法的核心构件,即一致性准则的不足进行了评价.利用偶极子给出了新的一致性准则,提出了数据分组处理(GMDH)聚类分析方法.从理论分析和实证比较两方面论证了新的一致性准则的优越性,指出了GMDH聚类分析方法是客观聚类分析方法的发展.     

基于干涉Cartwheel编队构形的系统参数定标

干涉Cartwheel是实现星载合成孔径雷达干涉测量(InSAR)的一种编队卫星构形。它能利用相对稳定的星间基线进行干涉测高,并通过系统参数定标获得高精度的地面数字高程模型(DEM)。首先利用干涉Cart-wheel的几何构形,建立了多基线干涉平台待定标参数之间的关系。然后在精确的星间测距基础上,将待定标参数关系引入到各干涉平台定标方程中,提出了多干涉平台联合定标算法。该算法利用干涉Cartwheel构形的冗余信息,不仅能一次联合修正多个干涉平台的系统参数,而且降低了地面定标控制点的实现要求。仿真表明该算法能给出较好的参数定标结果,并重建出精确的地形高程。     

面向目标和基于活动效用的组织知识创新模型

针对组织知识创新内在机制存在的不足,提出了活动效用概念以及面向目标和基于活动的知识创新模型.活动效用用于描述活动对完成目标任务的有效性,该模型集成了工作流和知识流,着眼于活动效用的改善,实现对组织业务过程的改进或再造从而达到对伴随与业务过程的知识的创新.通过对医院门诊就诊流程改造,表明该知识创新模型具有一定的有效性.     

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia

Phosphodiesterases (PDEs) regulate cyclic nucleotide levels. Increased cyclic AMP (cAMP) signaling has been associated with PRKAR1A or GNAS mutations and leads to adrenocortical tumors and Cushing syndrome. We investigated the genetic source of Cushing syndrome in individuals with adrenocortical hyperplasia that was not caused by known defects. We performed genome-wide SNP genotyping, including the adrenocortical tumor DNA. The region with the highest probability to harbor a susceptibility gene by loss of heterozygosity (LOH) and other analyses was 2q31-2q35. We identified mutations disrupting the expression of the PDE11A isoform-4 gene (PDE11A) in three kindreds. Tumor tissues showed 2q31-2q35 LOH, decreased protein expression and high cyclic nucleotide levels and cAMP-responsive element binding protein (CREB) phosphorylation. PDE11A codes for a dual-specificity PDE that is expressed in adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors; its germline inactivation is associated with adrenocortical hyperplasia, suggesting another means by which dysregulation of cAMP signaling causes endocrine tumors.     

PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

Ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal desquamation over the whole body, for which the genetic causes of several human forms remain unknown. We used a spontaneous dog model in the golden retriever breed, which is affected by a lamellar ichthyosis resembling human autosomal recessive congenital ichthyoses (ARCI), to carry out a genome-wide association study. We identified a homozygous insertion-deletion (indel) mutation in PNPLA1 that leads to a premature stop codon in all affected golden retriever dogs. We subsequently found one missense and one nonsense mutation in the catalytic domain of human PNPLA1 in six individuals with ARCI from two families. Further experiments highlighted the importance of PNPLA1 in the formation of the epidermal lipid barrier. This study identifies a new gene involved in human ichthyoses and provides insights into the localization and function of this yet uncharacterized member of the PNPLA protein family.     

C－正规、M－正规与有限群的结构

本文利用C－正规子群及M－正规子群的性质刻划有限群的可解性、P－闭性、幂零性。     

试论如何提高多校区图书馆读者服务效益

文章针对当前多校区图书馆发展中普遍存在的馆舍分散、文献分散、人力分散、共享程度低的现状,探讨了多校区图书馆提高规模效益的一些措施.     

人参多肽最低构象能计算分析

本文采用黄金分割法优化初始构象,运行ECEPP/2程序计算得到人参十四肽最低构象能为467.582KJ/mol;根据计算的原子坐标绘制的分子结构图表明最低构象能下的人参十四肽构象由β—折叠肽段及α—螺旋肽段构成.