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101.
Separation of bone marrow cells by sedimentation at unit gravity 总被引:7,自引:0,他引:7
102.
Images: keep a distinction between beauty and truth 总被引:1,自引:0,他引:1
Peterson DA 《Nature》2005,435(7044):881
103.
Berger E Price PA Cenko SB Gal-Yam A Soderberg AM Kasliwal M Leonard DC Cameron PB Frail DA Kulkarni SR Murphy DC Krzeminski W Piran T Lee BL Roth KC Moon DS Fox DB Harrison FA Persson SE Schmidt BP Penprase BE Rich J Peterson BA Cowie LL 《Nature》2005,438(7070):988-990
Despite a rich phenomenology, gamma-ray bursts (GRBs) are divided into two classes based on their duration and spectral hardness--the long-soft and the short-hard bursts. The discovery of afterglow emission from long GRBs was a watershed event, pinpointing their origin to star-forming galaxies, and hence the death of massive stars, and indicating an energy release of about 10(51) erg. While theoretical arguments suggest that short GRBs are produced in the coalescence of binary compact objects (neutron stars or black holes), the progenitors, energetics and environments of these events remain elusive despite recent localizations. Here we report the discovery of the first radio afterglow from the short burst GRB 050724, which unambiguously associates it with an elliptical galaxy at a redshift z = 0.257. We show that the burst is powered by the same relativistic fireball mechanism as long GRBs, with the ejecta possibly collimated in jets, but that the total energy release is 10-1,000 times smaller. More importantly, the nature of the host galaxy demonstrates that short GRBs arise from an old (> 1 Gyr) stellar population, strengthening earlier suggestions and providing support for coalescing compact object binaries as the progenitors. 相似文献
104.
Xu P Widmer G Wang Y Ozaki LS Alves JM Serrano MG Puiu D Manque P Akiyoshi D Mackey AJ Pearson WR Dear PH Bankier AT Peterson DL Abrahamsen MS Kapur V Tzipori S Buck GA 《Nature》2004,431(7012):1107-1112
Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporidium is transmitted by ingestion of oocysts and completes its life cycle in a single host. No therapy is available, and control focuses on eliminating oocysts in water supplies. Two species, C. hominis and C. parvum, which differ in host range, genotype and pathogenicity, are most relevant to humans. C. hominis is restricted to humans, whereas C. parvum also infects other mammals. Here we describe the eight-chromosome approximately 9.2-million-base genome of C. hominis. The complement of C. hominis protein-coding genes shows a striking concordance with the requirements imposed by the environmental niches the parasite inhabits. Energy metabolism is largely from glycolysis. Both aerobic and anaerobic metabolisms are available, the former requiring an alternative electron transport system in a simplified mitochondrion. Biosynthesis capabilities are limited, explaining an extensive array of transporters. Evidence of an apicoplast is absent, but genes associated with apical complex organelles are present. C. hominis and C. parvum exhibit very similar gene complements, and phenotypic differences between these parasites must be due to subtle sequence divergence. 相似文献
105.
C. C. J. Culvenor M. Clarke J. A. Edgar J. L. Frahn M. V. Jago J. E. Peterson L. W. Smith 《Cellular and molecular life sciences : CMLS》1980,36(4):377-379
Summary Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves ofSymphytum × uplandicum The combined alkaloids exhibit chronic hepatotoxicity in rats.The authors thank N. Anderton and P. Stewart for skilled assistance and V. Lord for statistical analyses. 相似文献
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Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways 总被引:9,自引:0,他引:9
L Teyton D O'Sullivan P W Dickson V Lotteau A Sette P Fink P A Peterson 《Nature》1990,348(6296):39-44
Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease. 相似文献
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