Therapeutic applications of bone marrow-derived stem cells in liver transplantation for end-stage liver diseases

Today, liver transplantation (LT) is the only established treatment for end-stage liver diseases. The de- velopment of LT, including OLT, cadaveric LT, split LT, living donor LT (LDLT), brings hopes to patients with these diseases. However, increasing donor shortage, rejection and life-long immunosuppression with its side effects are the major limitations of this therapy strategy. Bone marrow-derived stem cells (BMDSCs) are capable of differentiating into hepatocyte-like cells and contribute to liver injury repair. The microenvironment of liver injury caused by rejection, ischemia/reperfusion, loss of liver mass, recurrence of HCV and "small-for-size syndrome" after LT can attract a variety of bone marrow-derived stem cell population to the peripheral circulation and then migration to the injury liver to promote the hepatic function restoration. Additionally, BMDSCs can also take part in the functional regeneration of living donor liver after LDLT. This participation in liver regeneration may be associated to the interac- tion between SDF-1and its receptor CXCR4, involving HGF, IL-8, MMP9, and VEGF/VEGFR-2. BMDSC with its bio-characteristics could maintain the allograft tolerance from different angles and in different ways. In conclusion, BMDSCs transplantation, as a new assistant therapeutic method for LT, will ex- pand the space of LT, and provide more survival opportunities for the patients suffering liver diseases in the future.     

等离子熔积成形混相瞬态场的Level-Set方法模拟

提出了一种二维等离子熔积成形瞬态模型,该模型描述了液／气界面的自由表面发展,并模拟了熔池内流体流动和传热．采用Level—Set方法处理液／气界面边界条件,考虑了熔体流动的主要驱动力——表面张力梯度、表面曲率、浮力以及工件表面的对流散热等因素．用固液相统一模型来描述固／液界面处的熔融和凝固过程,并开发了相应的软件．对高温合金K163在不同扫描速度下的熔积层表面形貌、温度场以及熔池内流场进行了模拟分析．     

一种新颖的5.8GHz微带贴片整流天线

微带贴片整流天线质量小,接收面积大,非常适合微波飞机、高空平台等微波输电中对天线质量要求严格的场合.文中借助IE3D V10.0、ADS 2003C等仿真软件对整流天线的参数进行优化,设计了一种新颖的5.8GHz微带贴片整流天线.试验结果表明,该整流天线系统的整流效率达78.2%,从而验证了该结构设计的可行性.     

*辽宁半干旱及半湿润地区ET0时空演变规律研究

为了研究气候变化条件下辽宁省ET₀的变化特征,本文以辽宁省56个站点1954-2016年的气象数据为基础,采用FAO推荐的Penman-Monteith公式对该地区的ET₀进行推算,并利用干旱指数综合分带法,将辽宁省分为半干旱地区和半湿润地区,并在半干旱和半湿润地区分别选择4个气象站,对其ET₀的时空变化特征进行分析。结果表明：全省多年平均ET₀大致呈下降趋势,但该趋势不明显,倾向率仅为－0.0001mm.10a;全省1954-2016年日均ET₀的多年平均值为2.382mm,日均ET₀在(2.380±0.300)mm的范围内波动。8个站点中喀左站、朝阳站、康平站、桓仁站、沈阳站和鞍山站ET₀呈极显著下降趋势,阜新站和大连站呈显著上升趋势。对ET₀的年际变化影响较显著的气象因素是相对湿度、日照时数。     

也谈“用惠斯通电桥测电阻”实验

本文主要对杨介信、陈国英编写《普通物理实验(二、电磁学部分)》“用惠斯通电桥测电阻”实验中δR_(x0)=(R_4/R_3)δR_2的含意等五个问题,提出自己的不同看法。     

基于复合左/右手传输线的双频微带贴片天线(英文)

复合左/右手传输线(CRLH TL)是一种兼具左手材料和右手材料性质的超电磁介质,其以奇异的特性受到科学界及工程界的重视.在微带天线领域,复合左/右手传输线结构可用于馈电网络、辐射单元,以及背景媒质的设计.采用复合左/右手传输线结构同时作为馈电电路及辐射单元,实现了同轴线与辐射贴片的良好匹配,以及天线的双频辐射特性.通过在复合左/右手传输线天线的接地板上加载缝隙,实现了调节天线谐振频率的目的.     

负载扰动观测器在SF型矢量控制系统中的应用

文章提出广义逆矩阵来设计离散型状态观测器的方法,用该法设计的观测器,可对SF型矢量控制系统的负载力矩进行估计,再进行前馈补偿。实验证明,该法可有效改善系统的动态性能。     

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor

The ubiquitylation of cell-cycle regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chromatid segregation and the exit from mitosis. Selection of APC/C targets is achieved through recognition of destruction motifs, predominantly the destruction (D)-box and KEN (Lys-Glu-Asn)-box. Although this process is known to involve a co-activator protein (either Cdc20 or Cdh1) together with core APC/C subunits, the structural basis for substrate recognition and ubiquitylation is not understood. Here we investigate budding yeast APC/C using single-particle electron microscopy and determine a cryo-electron microscopy map of APC/C in complex with the Cdh1 co-activator protein (APC/C(Cdh1)) bound to a D-box peptide at ～10 ? resolution. We find that a combined catalytic and substrate-recognition module is located within the central cavity of the APC/C assembled from Cdh1, Apc10--a core APC/C subunit previously implicated in substrate recognition--and the cullin domain of Apc2. Cdh1 and Apc10, identified from difference maps, create a co-receptor for the D-box following repositioning of Cdh1 towards Apc10. Using NMR spectroscopy we demonstrate specific D-box-Apc10 interactions, consistent with a role for Apc10 in directly contributing towards D-box recognition by the APC/C(Cdh1) complex. Our results rationalize the contribution of both co-activator and core APC/C subunits to D-box recognition and provide a structural framework for understanding mechanisms of substrate recognition and catalysis by the APC/C.     

螺旋输送机螺旋体挠度有限元分析

首次使用ＳＡＰ５软件对螺旋体整体结构进行了有限元分析，并分别使用ＦＯＲＴＲＡＮ和ＢＡＳＩＣ语言编制了可供实用的前后处理程序．笔者认为：采用有限元法对螺旋体挽度分析计算结果较过去的使用值为小，从而在同样工况下，可减小螺旋轴直径，使结构紧凑轻便，成本降低．实验证实了其结果的正确性．     

直达列车取送车顺序的优化

本文根据组合最优化原理将直达列车最佳取送车顺序的绝对计算法简化为分析计算法,使之更便于实际应用.