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排序方式: 共有8600条查询结果,搜索用时 296 毫秒
311.
基于遗传算法的火电机组运行优化 总被引:1,自引:1,他引:0
火电机组运行优化正成为火电厂运行工作和技术攻关的重要方面.文中结合某300MW燃煤机组运行实例,对其主要性能参数进行敏感性分析,得出性能参数偏差对煤耗率的影响规律,其中,飞灰含碳量、炉膛出口烟气含氧量、排烟温度、凝汽器真空度、给水温度、主蒸汽压力6个参数的每工程单位偏差对煤耗率的影响最大.在此基础上,建立了以煤耗率最低为目标函数的优化模型,并采用遗传算法进行寻优求解.最后,开发了火电机组运行优化软件,并在其上进行机组运行优化计算,得到了一个参数最优化的运行方案.优化结果表明,供电标准煤耗率比原来降低了约1.41 g/(kW.h). 相似文献
312.
通过对旋转雷诺数R,喷射雷诺数Rej,喷嘴宽度和圆筒直径比B/d,喷射距离与喷嘴宽度之比L/B等影响旋转圆筒表面传质特性参数的实验研究,发现:在空气喷射作用下,由旋转产生的第一临界点消失,只存在第二临界点;平均舍伍德数Sh与Rej,B/d和L/B之间的关联式为Sh=0.515Re^2/3(B/d)^0.3(L/B)^0.1;空气喷射对圆筒表面传质的强化作用大于旋转的作用. 相似文献
313.
应用生物信息学数据库查询的方法,对B ioS tarM-140s小鼠基因表达芯片上的14 112个基因进行相应注释信息的查询和所对应蛋白质功能的分类.首先参照人类综合型芯片上基因的功能分类,设定了14个蛋白质类别,然后采用V isual C 编程语言,构建了基因信息查询系统.应用该查询系统,进行了网络生物学数据库信息资源的自动直接查询,共搜索到有注释信息的基因12 070个;进一步按照所设定的14个蛋白质类别对12 070个基因进行分类查询,搜索到了与这14个分类相符合的、具有详细蛋白质功能注释信息的基因共1 606个. 相似文献
314.
膜生物反应器净化污水的硝化反硝化性能 总被引:2,自引:0,他引:2
比较了膜生物反应器(MBR)和传统活性污泥工艺(CAS)在相同运行条件下处理生活污水的硝化和反硝化性能.结果表明,MBR对NH4 -N和TN的去除率分别比CAS高54.8%和37.3%.2种工艺的亚硝化、反硝化作用均呈零级反应,对应降解速率常数MBR分别约为CAS的2.2倍和2.5倍;CAS中硝化作用为零级反应,而MBR中硝化作用随时间推移趋于平缓.MBR中的细菌总数、硝酸菌、亚硝酸菌和反硝化菌数量分别比CAS工艺中相应菌种高1~2个数量级.通过控制曝气强度或减小回流通道断面限制缺氧区溶解氧质量浓度,可提高MBR中的反硝化效果. 相似文献
315.
Mingqiang Li Shuzhen Yang Ruochen Shi Linglong Li Ruixue Zhu Xiaomei Li Yang Cheng Xiumei Ma Jingmin Zhang Kaihui Liu Pu Yu Peng Gao 《科学通报(英文版)》2021,(8):771-776
Confined low dimensional charges with high density such as two-dimensional electron gas (2DEG) at interfaces and charged domain walls in ferroelectrics show gre... 相似文献
316.
This paper introduces a novel generalized autoregressive conditional heteroskedasticity–mixed data sampling–extreme shocks (GARCH-MIDAS-ES) model for stock volatility to examine whether the importance of extreme shocks changes in different time ranges. Based on different combinations of the short- and long-term effects caused by extreme events, we extend the standard GARCH-MIDAS model to characterize the different responses of the stock market for short- and long-term horizons, separately or in combination. The unique timespan of nearly 100 years of the Dow Jones Industrial Average (DJIA) daily returns allows us to understand the stock market volatility under extreme shocks from a historical perspective. The in-sample empirical results clearly show that the DJIA stock volatility is best fitted to the GARCH-MIDAS-SLES model by including the short- and long-term impacts of extreme shocks for all forecasting horizons. The out-of-sample results and robustness tests emphasize the significance of decomposing the effect of extreme shocks into short- and long-term effects to improve the accuracy of the DJIA volatility forecasts. 相似文献
317.
318.
Zhang Z Lee JC Lin L Olivas V Au V LaFramboise T Abdel-Rahman M Wang X Levine AD Rho JK Choi YJ Choi CM Kim SW Jang SJ Park YS Kim WS Lee DH Lee JS Miller VA Arcila M Ladanyi M Moonsamy P Sawyers C Boggon TJ Ma PC Costa C Taron M Rosell R Halmos B Bivona TG 《Nature genetics》2012,44(8):852-860
Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire resistance. Secondary mutations in EGFR (such as T790M) or upregulation of the MET kinase are found in over 50% of resistant tumors. Here, we report increased activation of AXL and evidence for epithelial-to-mesenchymal transition (EMT) in multiple in vitro and in vivo EGFR-mutant lung cancer models with acquired resistance to erlotinib in the absence of the EGFR p.Thr790Met alteration or MET activation. Genetic or pharmacological inhibition of AXL restored sensitivity to erlotinib in these tumor models. Increased expression of AXL and, in some cases, of its ligand GAS6 was found in EGFR-mutant lung cancers obtained from individuals with acquired resistance to TKIs. These data identify AXL as a promising therapeutic target whose inhibition could prevent or overcome acquired resistance to EGFR TKIs in individuals with EGFR-mutant lung cancer. 相似文献
319.
Dobbins SE Broderick P Melin B Feychting M Johansen C Andersson U Brännström T Schramm J Olver B Lloyd A Ma YP Hosking FJ Lönn S Ahlbom A Henriksson R Schoemaker MJ Hepworth SJ Hoffmann P Mühleisen TW Nöthen MM Moebus S Eisele L Kosteljanetz M Muir K Swerdlow A Simon M Houlston RS 《Nature genetics》2011,43(9):825-827
To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development. 相似文献
320.
Xiaofeng Ma He Li Yating He Junwei Hao 《Cellular and molecular life sciences : CMLS》2017,74(20):3667-3686
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is involved in the regulation of many cellular cascades and neurological diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke. In the brain, the expression of O-GlcNAcylation is notably heightened, as is that of O-linked N-acetylglucosaminyltransferase (OGT) and β-N-acetylglucosaminidase (OGA), the presence of which is prominent in many regions of neurological importance. Most importantly, O-GlcNAcylation is believed to contribute to the normal functioning of neurons; conversely, its dysregulation participates in the pathogenesis of neurological disorders. In neurodegenerative diseases, O-GlcNAcylation of the brain’s key proteins, such as tau and amyloid-β, interacts with their phosphorylation, thereby triggering the formation of neurofibrillary tangles and amyloid plaques. An increase of O-GlcNAcylation by pharmacological intervention prevents neuronal loss. Additionally, O-GlcNAcylation is stress sensitive, and its elevation is cytoprotective. Increased O-GlcNAcylation ameliorated brain damage in victims of both trauma-hemorrhage and stroke. In this review, we summarize the current understanding of O-GlcNAcylation’s physiological and pathological roles in the nervous system and provide a foundation for development of a therapeutic strategy for neurological disorders. 相似文献